Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Proc Natl Acad Sci U S A
1999 Mar 30;967:4061-6. doi: 10.1073/pnas.96.7.4061.
Show Gene links
Show Anatomy links
Evidence of a role for cyclic ADP-ribose in long-term synaptic depression in hippocampus.
Reyes-Harde M
,
Empson R
,
Potter BV
,
Galione A
,
Stanton PK
.
???displayArticle.abstract???
Ca2+ released from presynaptic and postsynaptic intracellular stores plays important roles in activity-dependent synaptic plasticity, including long-term depression (LTD) of synaptic strength. At Schaffer collateral-CA1 synapses in the hippocampus, presynaptic ryanodine receptor-gated stores appear to mobilize some of the Ca2+ necessary to induce LTD. Cyclic ADP-ribose (cADPR) has recently been proposed as an endogenous activator of ryanodine receptors in sea urchin eggs and several mammalian cell types. Here, we provide evidence that cADPR-mediated signaling pathways play a key role in inducing LTD. We show that biochemical production of cGMP increases cADPR concentration in hippocampal slices in vitro, and that blockade of cGMP-dependent protein kinase, cADPR receptors, or ryanodine-sensitive Ca2+ stores each prevent the induction of LTD at Schaffer collateral-CA1 synapses. A lack of effect of postsynaptic infusion of either cADPR antagonist indicates a probable presynaptic site of action.
Berridge,
Cell signalling. A tale of two messengers.
1993, Pubmed
Berridge,
Cell signalling. A tale of two messengers.
1993,
Pubmed
Boulton,
The nitric oxide--cyclic GMP pathway and synaptic depression in rat hippocampal slices.
1994,
Pubmed
Butt,
(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor.
1994,
Pubmed
Gage,
Nitric-oxide-guanylyl-cyclase-dependent and -independent components of multiple forms of long-term synaptic depression.
1997,
Pubmed
Galione,
Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose.
1991,
Pubmed
,
Echinobase
Galione,
cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis.
1993,
Pubmed
,
Echinobase
Izumi,
Nitric oxide and long-term synaptic depression in the rat hippocampus.
1993,
Pubmed
Kase,
K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases.
1987,
Pubmed
Lee,
Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+-mobilizing activity.
1989,
Pubmed
,
Echinobase
Lee,
Cyclic ADP ribose activation of the ryanodine receptor is mediated by calmodulin.
1994,
Pubmed
,
Echinobase
Mulkey,
An essential role for protein phosphatases in hippocampal long-term depression.
1993,
Pubmed
Mulkey,
Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression.
1994,
Pubmed
Mulkey,
Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus.
1992,
Pubmed
Oliet,
Two distinct forms of long-term depression coexist in CA1 hippocampal pyramidal cells.
1997,
Pubmed
Reyes,
Induction of hippocampal long-term depression requires release of Ca2+ from separate presynaptic and postsynaptic intracellular stores.
1996,
Pubmed
Sethi,
7-Deaza-8-bromo-cyclic ADP-ribose, the first membrane-permeant, hydrolysis-resistant cyclic ADP-ribose antagonist.
1997,
Pubmed
,
Echinobase
Stanton,
Distinct synaptic loci of Ca2+/calmodulin-dependent protein kinase II necessary for long-term potentiation and depression.
1996,
Pubmed
Takasawa,
Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca2+ mobilization.
1995,
Pubmed
Walseth,
Synthesis and characterization of antagonists of cyclic-ADP-ribose-induced Ca2+ release.
1993,
Pubmed
,
Echinobase
Wang,
Induction of LTD in the dentate gyrus in vitro is NMDA receptor independent, but dependent on Ca2+ influx via low-voltage-activated Ca2+ channels and release of Ca2+ from intracellular stores.
1997,
Pubmed
Willmott,
Nitric oxide-induced mobilization of intracellular calcium via the cyclic ADP-ribose signaling pathway.
1996,
Pubmed
,
Echinobase
