Cell 1976 Dec 01;94 Pt 1:589-95. doi: 10.1016/0092-8674(76)90041-6.

Methylated blocked 5'' terminal sequences of sea urchin embryo messenger RNA classes containing and lacking poly(A).

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Sea urchin embryo mRNAs of three distinct classes--histone mRNA, nonhistone mRNA containing poly(A), "[+A] mRNA," and nonhistone mRNA lacking poly(A), "[-A]mRNA"--all contain blocked 5'' terminal sequences in which 7-methylguanosine is linked 5''-5'' via a triphosphate bridge to a 2''-0-methylated nucleotide. Only one general type of 5'' terminal structure, 7mGpppXmpYp, is present. Additional 2''-0-methylation in the Y residue has not been found either in early or late stage embryos. A substantial proportion of the polyribosomal mRNAs in all three classes contain this blocked structure. Whereas both classes of nonhistone mRNAs have internal base methylations, histone mRNAs lack such modifications.

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Genes referenced: LOC100887844