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Proc Natl Acad Sci U S A
1985 Dec 01;8223:8062-6. doi: 10.1073/pnas.82.23.8062.
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Characterization of toposomes from sea urchin blastula cells: a cell organelle mediating cell adhesion and expressing positional information.
Noll H
,
Matranga V
,
Cervello M
,
Humphreys T
,
Kuwasaki B
,
Adelson D
.
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Cell adhesion in the sea urchin blastula is mediated by a 22S genus-specific glycoprotein complex consisting initially of six 160-kDa subunits that are processed proteolytically as development proceeds. Noncytolytic removal of the 22S particle from the surface with either 2.5% butanol or trypsin renders dissociated cells reaggregation incompetent, and addition restores reaggregation and development. Polyclonal antibodies against the 22S complex prevent reaggregation in a genus-specific manner while monoclonal antibodies stain cell surface structures in a pattern consistent with a code that specifies the position of a cell in the embryo by a unique combination of subunits in its cell adhesion particles. The existence of similar particles in Drosophila and amphibian embryos suggests that these glycoprotein complexes are a general class of organelles, the toposomes, that in the embryo mediate cell adhesion and express positional information.
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