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ECB-ART-44690
Molecules 2016 May 12;215:. doi: 10.3390/molecules21050625.
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In Vivo Anti-Cancer Mechanism of Low-Molecular-Weight Fucosylated Chondroitin Sulfate (LFCS) from Sea Cucumber Cucumaria frondosa.

Liu X , Liu Y , Hao J , Zhao X , Lang Y , Fan F , Cai C , Li G , Zhang L , Yu G .


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The low-molecular-weight fucosylated chondroitin sulfate (LFCS) was prepared from native fucosylated chondroitin sulfate (FCS), which was extracted and isolated from sea cucumber Cucumaria frondosa, and the anti-cancer mechanism of LFCS on mouse Lewis lung carcinoma (LLC) was investigated. The results showed that LFCS remarkably inhibited LLC growth and metastasis in a dose-dependent manner. LFCS induced cell cycle arrest by increasing p53/p21 expression and apoptosis through activation of caspase-3 activity in LLC cells. Meanwhile, LFCS suppressed the expression of vascular endothelial growth factor (VEGF), increased the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) and downregulated the matrix metalloproteinases (MMPs) level. Furthermore, LFCS significantly suppressed the activation of ERK1/2/p38 MAPK/NF-κB pathway, which played a prime role in expression of MMPs. All of these data indicate LFCS may be used as anti-cancer drug candidates and deserve further study.

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Genes referenced: LOC100887844 LOC100893907 LOC115919910 LOC115922368 LOC583082 LOC590297 LOC592256 mapk1 mmp7 vegfc


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References [+] :
Al Saleh, Signalling pathways involved in endocrine resistance in breast cancer and associations with epithelial to mesenchymal transition (Review). 2011, Pubmed