Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-39880
FEBS Lett 2006 Aug 21;58019:4713-7. doi: 10.1016/j.febslet.2006.07.049.
Show Gene links Show Anatomy links

Lack of age-associated telomere shortening in long- and short-lived species of sea urchins.

Francis N , Gregg T , Owen R , Ebert T , Bodnar A .


???displayArticle.abstract???
The red sea urchin, Strongylocentrotus franciscanus, can live in excess of 100 years while the sea urchin Lytechinus variegatus has an estimated lifespan of only 3-4 years. In an effort to understand the molecular mechanism underlying the difference in their longevity we characterized telomere biology in these species of sea urchins. Telomerase activity was found throughout early stages of development in L. variegatus and is maintained in adult tissues of L. variegatus and S. franciscanus. Terminal restriction fragment analysis indicated a lack of age-associated telomere shortening. These data suggest that long- and short-lived sea urchins do not utilize telomerase repression as a mechanism to suppress neoplastic transformation.

???displayArticle.pubmedLink??? 16876792
???displayArticle.link??? FEBS Lett


Genes referenced: LOC100887844