ECB-ART-48087
Bioorg Khim
2001 Jan 01;273:227-30. doi: 10.1023/a:1011341623358.
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[Arachidonoylcholine and N,N-dimethylaminoethyl arachidonate are new cholinergic compounds].
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Choline and N,N-dimethylaminoethyl esters of arachidonic and some other fatty acids were synthesized. Experiments on the embryos and larvae of sea urchins, sensitive to cholinergic compounds, showed that arachidonoylcholine exhibited cholinomimetic activity similar to that of nicotine whereas N,N-dimethylaminoethyl arachidonate acted as an acetylcholine antagonist. The corresponding esters of docosahexaenoic acid displayed similar biological properties.
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Genes referenced: LOC100887844