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ECB-ART-37188
Mol Biol Evol 1999 May 01;165:634-45. doi: 10.1093/oxfordjournals.molbev.a026146.
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Molecular characterization and phylogenetic analysis of SpBMP5-7, a new member of the TGF-beta superfamily expressed in sea urchin embryos.

Ponce MR , Micol JL , Peterson KJ , Davidson EH .


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TGF-beta ligands are probably pan-bilaterian in phylogenetic distribution. The family appears to have diversified greatly with the evolution of the vertebrates, but only a few invertebrate deuterostome TGF-beta molecules have so far been isolated. A search for members of this family expressed in sea urchin embryos, using canonical PCR primers, revealed a single-copy gene encoding a new TGF-beta protein. The sequence which it encodes is closely related to those of vertebrate bone morphogenetic proteins (BMPs) 5-7. No additional TGF-beta family members were uncovered other than univin, which had previously been reported.

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Genes referenced: LOC100887844 LOC588471 LOC764641 univin