Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Biochem J
2007 Mar 01;4022:301-10. doi: 10.1042/BJ20060759.
Show Gene links
Show Anatomy links
NAADP induces pH changes in the lumen of acidic Ca2+ stores.
Morgan AJ
,
Galione A
.
???displayArticle.abstract???
NAADP (nicotinic acid-adenine dinucleotide phosphate)-induced Ca2+ release has been proposed to occur selectively from acidic stores in several cell types, including sea urchin eggs. Using fluorescence measurements, we have investigated whether NAADP-induced Ca2+ release alters the pH(L) (luminal pH) within these acidic stores in egg homogenates and observed their prompt, concentration-dependent alkalinization by NAADP (but not beta-NAD+ or NADP). Like Ca2+ release, the pH(L) change was desensitized by low concentrations of NAADP suggesting it was secondary to NAADP receptor activation. Moreover, this was a direct effect of NAADP upon the acidic stores and not secondary to increases in cytosolic Ca2+ as it was not mimicked by IP3 (inositol 1,4,5-trisphosphate), cADPR (cyclic adenine diphosphoribose), ionomycin, thapsigargin or by direct addition of Ca2+, and was not blocked by EGTA. The results of the present study further support acidic stores as targets for NAADP and for the first time reveal an adjunct role for NAADP in regulating the pH(L) of intracellular organelles.
Beyenbach,
The V-type H+ ATPase: molecular structure and function, physiological roles and regulation.
2006, Pubmed
Beyenbach,
The V-type H+ ATPase: molecular structure and function, physiological roles and regulation.
2006,
Pubmed
Brailoiu,
Nicotinic acid adenine dinucleotide phosphate potentiates neurite outgrowth.
2005,
Pubmed
Burdakov,
Intraluminal calcium as a primary regulator of endoplasmic reticulum function.
2005,
Pubmed
Busch,
Studies on the mechanism of swelling-induced lysosomal alkalinization in vascular smooth muscle cells.
1996,
Pubmed
Christensen,
pH-dependent regulation of lysosomal calcium in macrophages.
2002,
Pubmed
Churchill,
Spatial control of Ca2+ signaling by nicotinic acid adenine dinucleotide phosphate diffusion and gradients.
2000,
Pubmed
,
Echinobase
Churchill,
NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs.
2002,
Pubmed
,
Echinobase
Csordás,
Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria.
1999,
Pubmed
Cunningham,
Calcineurin inhibits VCX1-dependent H+/Ca2+ exchange and induces Ca2+ ATPases in Saccharomyces cerevisiae.
1996,
Pubmed
Demaurex,
pH Homeostasis of cellular organelles.
2002,
Pubmed
Fasolato,
Intracellular Ca2+ pools in PC12 cells. Three intracellular pools are distinguished by their turnover and mechanisms of Ca2+ accumulation, storage, and release.
1991,
Pubmed
Galione,
NAADP receptors.
2005,
Pubmed
,
Echinobase
Genazzani,
Unique inactivation properties of NAADP-sensitive Ca2+ release.
1996,
Pubmed
,
Echinobase
Genazzani,
Pharmacological properties of the Ca2+-release mechanism sensitive to NAADP in the sea urchin egg.
1997,
Pubmed
,
Echinobase
Gerasimenko,
NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area.
2006,
Pubmed
Gerasimenko,
NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors.
2003,
Pubmed
Hedrich,
Comparative studies on the electrical properties of the H+ translocating ATPase and pyrophosphatase of the vacuolar-lysosomal compartment.
1989,
Pubmed
Kinnear,
Lysosome-sarcoplasmic reticulum junctions. A trigger zone for calcium signaling by nicotinic acid adenine dinucleotide phosphate and endothelin-1.
2004,
Pubmed
Lee,
Changes in intracellular acidic compartments in sea urchin eggs after activation.
1983,
Pubmed
,
Echinobase
Lee,
A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose.
1995,
Pubmed
,
Echinobase
Lee,
Multiplicity of Ca2+ messengers and Ca2+ stores: a perspective from cyclic ADP-ribose and NAADP.
2004,
Pubmed
López,
Ca2+ accumulation into acidic organelles mediated by Ca2+- and vacuolar H+-ATPases in human platelets.
2005,
Pubmed
Marchesini,
Acidocalcisomes and a vacuolar H+-pyrophosphatase in malaria parasites.
2000,
Pubmed
Martinez,
Alterations in Ca2+ storage and mobilization in submandibular acinar cells of reserpine-treated rats.
1998,
Pubmed
Milani,
Ca(2+) transport into an intracellular acidic compartment of Candida parapsilosis.
2001,
Pubmed
Missiaen,
SPCA1 pumps and Hailey-Hailey disease.
2004,
Pubmed
Mitchell,
Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6).
2003,
Pubmed
Moccia,
NAADP triggers the fertilization potential in starfish oocytes.
2004,
Pubmed
,
Echinobase
Moreno,
Calcium dynamics in catecholamine-containing secretory vesicles.
2005,
Pubmed
Morgan,
Single cell and subcellular measurement of intracellular Ca2+ concentration ([Ca2+]i).
1999,
Pubmed
Mándi,
Ca2+ release triggered by NAADP in hepatocyte microsomes.
2006,
Pubmed
,
Echinobase
Navazio,
Calcium release from the endoplasmic reticulum of higher plants elicited by the NADP metabolite nicotinic acid adenine dinucleotide phosphate.
2000,
Pubmed
,
Echinobase
Nguyen,
Role of Ca2+/K+ ion exchange in intracellular storage and release of Ca2+.
1998,
Pubmed
Papp,
Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca2+-handling proteins.
2003,
Pubmed
Patel,
Coordination of Ca2+ signalling by NAADP.
2001,
Pubmed
Petersen,
Can Ca2+ be released from secretory granules or synaptic vesicles?
1996,
Pubmed
Pittman,
Evidence of differential pH regulation of the Arabidopsis vacuolar Ca2+/H+ antiporters CAX1 and CAX2.
2005,
Pubmed
Pozos,
The product of HUM1, a novel yeast gene, is required for vacuolar Ca2+/H+ exchange and is related to mammalian Na+/Ca2+ exchangers.
1996,
Pubmed
Quesada,
ATP-independent luminal oscillations and release of Ca2+ and H+ from mast cell secretory granules: implications for signal transduction.
2003,
Pubmed
Renström,
Inositol 3,4,5,6-tetrakisphosphate inhibits insulin granule acidification and fusogenic potential.
2002,
Pubmed
Rodrigues,
Characterization of a vacuolar pyrophosphatase in Trypanosoma brucei and its localization to acidocalcisomes.
1999,
Pubmed
Ruiz,
Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes.
2004,
Pubmed
Srinivas,
Lysosomal Ca(2+) stores in bovine corneal endothelium.
2002,
Pubmed
Thévenod,
Ion channels in secretory granules of the pancreas and their role in exocytosis and release of secretory proteins.
2002,
Pubmed
Wang,
Influence of membrane physical state on lysosomal potassium ion permeability.
2005,
Pubmed
Yagodin,
Functional characterization of thapsigargin and agonist-insensitive acidic Ca2+ stores in Drosophila melanogaster S2 cell lines.
1999,
Pubmed
Yamaguchi,
Vacuolar Na+/H+ antiporter cation selectivity is regulated by calmodulin from within the vacuole in a Ca2+- and pH-dependent manner.
2005,
Pubmed
Yamasaki,
Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
2004,
Pubmed
