Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-31899
Toxicon 1989 Jan 01;278:927-36. doi: 10.1016/0041-0101(89)90104-9.
Show Gene links Show Anatomy links

Inhibition of rat brain Na+-K+-ATPase by triterpene glycosides from holothurians.

Gorshkova IA , Gorshkov BA , Stonik VA .


???displayArticle.abstract???
The effect of triterpene glycosides from holothurians on Na+-K+-ATPase of rat brain was investigated. The marine glycosides are irreversible inhibitors of the enzyme with an average I50 value of 10(-4) M. ATP had a low protective effect against inhibition. The inhibitory effect was increased by preincubation with MgCl2. There was alteration of the activation curve of Na+-K+-ATPase by NaCl and KCl in the presence of glycosides. Triterpene glycosides inhibited the K+-phosphatase activity, but to a smaller degree than the ATPase activity. Na+-K+-ATPase of pig kidney was less sensitive to the marine triterpene glycosides than the brain enzyme. The marine glycosides did not alter the specific binding of [3H]-ouabain to the Na+-K+-ATPase.

???displayArticle.pubmedLink??? 2551077
???displayArticle.link??? Toxicon


Genes referenced: LOC581395