Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Proc Natl Acad Sci U S A
2008 Dec 23;10551:20063-6. doi: 10.1073/pnas.0806007105.
Show Gene links
Show Anatomy links
Properties of developmental gene regulatory networks.
Davidson EH
,
Levine MS
.
???displayArticle.abstract???
The modular components, or subcircuits, of developmental gene regulatory networks (GRNs) execute specific developmental functions, such as the specification of cell identity. We survey examples of such subcircuits and relate their structures to corresponding developmental functions. These relations transcend organisms and genes, as illustrated by the similar structures of the subcircuits controlling the specification of the mesectoderm in the Drosophila embryo and the endomesoderm in the sea urchin, even though the respective subcircuits are composed of nonorthologous regulatory genes.
Casey,
The T-box transcription factor Brachyury regulates expression of eFGF through binding to a non-palindromic response element.
1998, Pubmed
Casey,
The T-box transcription factor Brachyury regulates expression of eFGF through binding to a non-palindromic response element.
1998,
Pubmed
De Renzis,
Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway.
2006,
Pubmed
Georgescu,
A gene regulatory network armature for T lymphocyte specification.
2008,
Pubmed
Gross,
Synteny and candidate gene prediction using an anchored linkage map of Astyanax mexicanus.
2008,
Pubmed
Hinman,
Developmental gene regulatory network architecture across 500 million years of echinoderm evolution.
2003,
Pubmed
,
Echinobase
Hobert,
Regulatory logic of neuronal diversity: terminal selector genes and selector motifs.
2008,
Pubmed
Hong,
How the Dorsal gradient works: insights from postgenome technologies.
2008,
Pubmed
Latinkić,
The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins.
1997,
Pubmed
Levine,
Gene regulatory networks for development.
2005,
Pubmed
,
Echinobase
Minokawa,
cis-Regulatory inputs of the wnt8 gene in the sea urchin endomesoderm network.
2005,
Pubmed
,
Echinobase
Nam,
Cis-regulatory control of the nodal gene, initiator of the sea urchin oral ectoderm gene network.
2007,
Pubmed
,
Echinobase
Nambu,
The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development.
1991,
Pubmed
Nikitina,
Dissecting early regulatory relationships in the lamprey neural crest gene network.
2008,
Pubmed
Ochoa-Espinosa,
Anterior-posterior positional information in the absence of a strong Bicoid gradient.
2009,
Pubmed
Oliveri,
Development. Built to run, not fail.
2007,
Pubmed
Oliveri,
Global regulatory logic for specification of an embryonic cell lineage.
2008,
Pubmed
,
Echinobase
Range,
LvNumb works synergistically with Notch signaling to specify non-skeletal mesoderm cells in the sea urchin embryo.
2008,
Pubmed
,
Echinobase
Ransick,
cis-regulatory processing of Notch signaling input to the sea urchin glial cells missing gene during mesoderm specification.
2006,
Pubmed
,
Echinobase
Revilla-i-Domingo,
A missing link in the sea urchin embryo gene regulatory network: hesC and the double-negative specification of micromeres.
2007,
Pubmed
,
Echinobase
Ririe,
The Caenorhabditis elegans vulva: a post-embryonic gene regulatory network controlling organogenesis.
2008,
Pubmed
Smith,
Gene regulatory network subcircuit controlling a dynamic spatial pattern of signaling in the sea urchin embryo.
2008,
Pubmed
,
Echinobase
Smith,
A gene regulatory network subcircuit drives a dynamic pattern of gene expression.
2007,
Pubmed
,
Echinobase
Smith,
A new method, using cis-regulatory control, for blocking embryonic gene expression.
2008,
Pubmed
,
Echinobase
Surkova,
Characterization of the Drosophila segment determination morphome.
2008,
Pubmed
Tümpel,
A regulatory module embedded in the coding region of Hoxa2 controls expression in rhombomere 2.
2008,
Pubmed
Usui,
Redundant mechanisms mediate bristle patterning on the Drosophila thorax.
2008,
Pubmed