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Front Endocrinol (Lausanne)
2019 Jan 01;10:284. doi: 10.3389/fendo.2019.00284.
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Potential Anti-obesogenic Effects of Ginkgo biloba Observed in Epididymal White Adipose Tissue of Obese Rats.
Hirata BKS
,
Cruz MM
,
de Sá RDCC
,
Farias TSM
,
Machado MMF
,
Bueno AA
,
Alonso-Vale MIC
,
Telles MM
.
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Exacerbated expansion of adipose tissue seen in diet-induced obesity leads to endocrine dysfunction and disturbance in adipokine secretion, with such abnormal profile positively associated with type 2 diabetes and other mild chronic inflammatory conditions. Ginkgo biloba extract (GbE), a mixture of polyphenols with antioxidant properties, has been recently investigated in a variety of experimental models of endocrine dysfunction, with several potentially beneficial effects identified, including improvement in insulin sensitivity in obese rats, and reduction of weight gain in ovariectomy-induced obesity and diet-induced obesity. The aim of this study was to investigate in high fat diet-induced obese male rats the effects of GbE supplementation for 2 weeks on adipocyte volume and adipose tissue lipid accumulation. GbE supplementation was effective in reducing energy intake in obese rats compared to the saline-treated placebo group. Epididymal adipocyte volume was reduced in GbE-supplemented rats, as were epididymal [1-14C]-acetate incorporation into fatty acids, perilipin (Plin 1) and fatty acid synthase (Fasn) mRNA, and FAS protein levels. Adipocyte hypertrophy in obesity is associated with insulin resistance, and in the present study we observed a reduction in the adipocyte volume of GbE-supplemented obese rats to dimensions equivalent to adipocytes from non-obese rats. GbE supplementation significantly reduced acetate accumulation and tended to reduce [3H]-oleate incorporation, into epididymal adipose tissue, suggesting a potentially anti-obesogenic effect in longer term therapies. Further studies that investigate the effects of GbE supplementation in other experimental models are required to fully elucidate its suggested beneficial effects on mild chronic inflammatory conditions.
Figure 6. Gene expression. Effect of GbE supplementation on epididymal adipose tissue gene expression of PLIN1 (A), FASN (B), and HSL (C), normal-fat diet (NFD; n = 6–4), high-fat diet (HFD; n = 5–3), and high-fat diet plus GbE supplementation (HFD+GbE; n = 6–4) groups. *p < 0.05 vs. NFD and #p < 0.05 vs. HFD (One-way ANOVA). Gene expression in epididymal WAT depot was evaluated by Real Time PCR.
Figure 7. Epididymal protein expression. Protein synthesis of FAS (A), p-HSL/tubulin (B), p-HSL/HSL (C), and HSL/tubulin (D) of normal fat diet (NFD; n = 9–6), high-fat diet (HFD; n = 12–7), and high-fat diet +GbE (HFD+GbE; n = 11–8). *p < 0.05 vs. NFD (One-way ANOVA).
Andersson,
Visceral fat cell lipolysis and cardiovascular risk factors in obesity.
2011, Pubmed
Andersson,
Visceral fat cell lipolysis and cardiovascular risk factors in obesity.
2011,
Pubmed
Banin,
Beneficial effects of Ginkgo biloba extract on insulin signaling cascade, dyslipidemia, and body adiposity of diet-induced obese rats.
2014,
Pubmed
,
Echinobase
Banin,
Ginkgo biloba Extract (GbE) Stimulates the Hypothalamic Serotonergic System and Attenuates Obesity in Ovariectomized Rats.
2017,
Pubmed
Berndt,
Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes.
2007,
Pubmed
Birks,
Ginkgo biloba for cognitive impairment and dementia.
2009,
Pubmed
Bolsoni-Lopes,
Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation.
2014,
Pubmed
,
Echinobase
Buettner,
High-fat diets: modeling the metabolic disorders of human obesity in rodents.
2007,
Pubmed
Cho,
Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation.
2019,
Pubmed
Choe,
Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders.
2016,
Pubmed
Corbett,
Energy expenditure in rats with diet-induced obesity.
1986,
Pubmed
Dell'Agli,
Biflavones of Ginkgo biloba stimulate lipolysis in 3T3-L1 adipocytes.
2002,
Pubmed
Ding,
Quantitative determination of major active components in Ginkgo biloba dietary supplements by liquid chromatography/mass spectrometry.
2006,
Pubmed
Dornellas,
Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions.
2015,
Pubmed
Fantuzzi,
Adipose tissue, adipokines, and inflammation.
2005,
Pubmed
Frühbeck,
Regulation of adipocyte lipolysis.
2014,
Pubmed
Hirata,
Ginkgo biloba extract improves insulin signaling and attenuates inflammation in retroperitoneal adipose tissue depot of obese rats.
2015,
Pubmed
,
Echinobase
Hotamisligil,
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.
1993,
Pubmed
Kern,
Perilipin expression in human adipose tissue is elevated with obesity.
2004,
Pubmed
Kubant,
A comparison of effects of lard and hydrogenated vegetable shortening on the development of high-fat diet-induced obesity in rats.
2015,
Pubmed
Kudolo,
The effect of the ingestion of Ginkgo biloba extract (EGb 761) on the pharmacokinetics of metformin in non-diabetic and type 2 diabetic subjects--a double blind placebo-controlled, crossover study.
2006,
Pubmed
Kumar,
Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice.
2002,
Pubmed
Lafontan,
Lipolysis and lipid mobilization in human adipose tissue.
2009,
Pubmed
Larson-Meyer,
Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects.
2006,
Pubmed
Lee,
Adipose tissue heterogeneity: implication of depot differences in adipose tissue for obesity complications.
2013,
Pubmed
Liang,
Inhibitory effects of grape skin extract and resveratrol on fatty acid synthase.
2013,
Pubmed
Lieberman,
Moderate doses of commercial preparations of Ginkgo biloba do not alter markers of liver function but moderate alcohol intake does: A new approach to identify and quantify biomarkers of 'adverse effects' of dietary supplements.
2017,
Pubmed
Liou,
Ginkgolide C Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway.
2015,
Pubmed
Livak,
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
2001,
Pubmed
Loftus,
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors.
2000,
Pubmed
Mahadevan,
Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses.
2008,
Pubmed
Martin,
New targets to treat obesity and the metabolic syndrome.
2015,
Pubmed
McLaughlin,
Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity.
2011,
Pubmed
Mobbs,
Block the FAS, lose the fat.
2002,
Pubmed
Monteiro,
Chronic inflammation in obesity and the metabolic syndrome.
2010,
Pubmed
Oliveira,
Neuromodulatory property of standardized extract Ginkgo biloba L. (EGb 761) on memory: behavioral and molecular evidence.
2009,
Pubmed
Priyanka,
Bilobalide abates inflammation, insulin resistance and secretion of angiogenic factors induced by hypoxia in 3T3-L1 adipocytes by controlling NF-κB and JNK activation.
2017,
Pubmed
Proença,
New concepts in white adipose tissue physiology.
2014,
Pubmed
Qiao,
Effects of resveratrol on gut microbiota and fat storage in a mouse model with high-fat-induced obesity.
2014,
Pubmed
Ramassamy,
Ginkgo biloba extract (EGb 761) in Alzheimer's disease: is there any evidence?
2007,
Pubmed
Rhee,
Extract of Ginkgo Biloba Ameliorates Streptozotocin-Induced Type 1 Diabetes Mellitus and High-Fat Diet-Induced Type 2 Diabetes Mellitus in Mice.
2015,
Pubmed
Ruan,
Adiponectin signaling and function in insulin target tissues.
2016,
Pubmed
Rutkowski,
The cell biology of fat expansion.
2015,
Pubmed
Saponara,
Inhibition of cAMP-phosphodiesterase by biflavones of Ginkgo biloba in rat adipose tissue.
1998,
Pubmed
Seo,
Quercetin prevents adipogenesis by regulation of transcriptional factors and lipases in OP9 cells.
2015,
Pubmed
Shimokawa,
Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides.
2002,
Pubmed
Singh,
Biology and chemistry of Ginkgo biloba.
2008,
Pubmed
Stich,
Physiological regulation of NEFA availability: lipolysis pathway.
2004,
Pubmed
Sáinz,
Leptin resistance and diet-induced obesity: central and peripheral actions of leptin.
2015,
Pubmed
Torres-Leal,
The role of inflamed adipose tissue in the insulin resistance.
2010,
Pubmed
Vázquez-Vela,
White adipose tissue as endocrine organ and its role in obesity.
2008,
Pubmed
Wang,
Inhibitory effect of Ginkgo biloba extract on fatty liver: regulation of carnitine palmitoyltransferase 1a and fatty acid metabolism.
2012,
Pubmed
Wueest,
Basal lipolysis, not the degree of insulin resistance, differentiates large from small isolated adipocytes in high-fat fed mice.
2009,
Pubmed
Yamashita,
Depot-specific modulation of adipokine levels in rat adipose tissue by diet-induced obesity: the effect of aerobic training and energy restriction.
2010,
Pubmed
Yan,
Protective effects of Ginkgo biloba leaf polysaccharide on nonalcoholic fatty liver disease and its mechanisms.
2015,
Pubmed
Yu,
Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissue.
2005,
Pubmed
Zhang,
Adipose "talks" to distant organs to regulate insulin sensitivity and vascular function.
2010,
Pubmed
Zhang,
An Overview of Systematic Reviews of Ginkgo biloba Extracts for Mild Cognitive Impairment and Dementia.
2016,
Pubmed
de Freitas Junior,
Medicinal plants for the treatment of obesity: ethnopharmacological approach and chemical and biological studies.
2017,
Pubmed
de Sá,
Fish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes.
2016,
Pubmed
,
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