Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Mediators Inflamm
2015 Jan 01;2015:419106. doi: 10.1155/2015/419106.
Show Gene links
Show Anatomy links
Ginkgo biloba extract improves insulin signaling and attenuates inflammation in retroperitoneal adipose tissue depot of obese rats.
Hirata BK
,
Banin RM
,
Dornellas AP
,
de Andrade IS
,
Zemdegs JC
,
Caperuto LC
,
Oyama LM
,
Ribeiro EB
,
Telles MM
.
???displayArticle.abstract???
Due to the high incidence and severity of obesity and its related disorders, it is highly desirable to develop new strategies to treat or even to prevent its development. We have previously described that Ginkgo biloba extract (GbE) improved insulin resistance and reduced body weight gain of obese rats. In the present study we aimed to evaluate the effect of GbE on both inflammatory cascade and insulin signaling in retroperitoneal fat depot of diet-induced obese rats. Rats were fed with high fat diet for 2 months and thereafter treated for 14 days with 500 mg/kg of GbE. Rats were then euthanized and samples from retroperitoneal fat depot were used for western blotting, RT-PCR, and ELISA experiments. The GbE treatment promoted a significant reduction on both food/energy intake and body weight gain in comparison to the nontreated obese rats. In addition, a significant increase of both Adipo R1 and IL-10 gene expressions and IR and Akt phosphorylation was also observed, while NF-κB p65 phosphorylation and TNF-α levels were significantly reduced. Our data suggest that GbE might have potential as a therapy to treat obesity-related metabolic diseases, with special interest to treat obese subjects resistant to adhere to a nutritional education program.
Figure 4. Effect of GbE on Akt phosphorylation levels of retroperitoneal fat depot: insulin-induced Akt phosphorylation levels in retroperitoneal WAT depot of groups: (a) O+V− (n = 8) and O+V+ (n = 9); (b) O+Gb− (n = 8) and O+Gb+ (n = 7) evaluated by western blotting. *
P < 0.05 versus basal levels.
Figure 5. Effect of GbE on inflammatory signaling pathway: total protein levels of TLR4 (O+V n = 6; O+Gb n = 6), MyD88 (O+V n = 13; O+Gb n = 9), NF-κB p65 (O+V n = 5; O+Gb n = 4), and phosphorylation of NF-κB p65 (O+V n = 10; O+Gb n = 8) in retroperitoneal WAT depot evaluated by western blotting. *
P < 0.05 versus O+V.
Azoulay,
Thiazolidinediones and the risk of incident strokes in patients with type 2 diabetes: a nested case-control study.
2010, Pubmed
Azoulay,
Thiazolidinediones and the risk of incident strokes in patients with type 2 diabetes: a nested case-control study.
2010,
Pubmed
Banin,
Beneficial effects of Ginkgo biloba extract on insulin signaling cascade, dyslipidemia, and body adiposity of diet-induced obese rats.
2014,
Pubmed
,
Echinobase
Boghdady,
Antioxidant and antiapoptotic effects of proanthocyanidin and ginkgo biloba extract against doxorubicin-induced cardiac injury in rats.
2013,
Pubmed
Buettner,
High-fat diets: modeling the metabolic disorders of human obesity in rodents.
2007,
Pubmed
Caperuto,
Distinct regulation of IRS proteins in adipose tissue from obese aged and dexamethasone-treated rats.
2006,
Pubmed
Cuypers,
SGLT2-inhibitors: a novel class for the treatment of type 2 diabetes introduction of SGLT2-inhibitors in clinical practice.
2013,
Pubmed
Federico,
Fat: a matter of disturbance for the immune system.
2010,
Pubmed
Formoso,
Magnetic resonance imaging determined visceral fat reduction associates with enhanced IL-10 plasma levels in calorie restricted obese subjects.
2012,
Pubmed
Graham,
Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone.
2010,
Pubmed
Hoefel,
The effects of hypercaloric diets on glucose homeostasis in the rat: influence of saturated and monounsaturated dietary lipids.
2011,
Pubmed
Hu,
Ginkgolide B reduces neuronal cell apoptosis in the hemorrhagic rat brain: possible involvement of Toll-like receptor 4/nuclear factor-kappa B pathway.
2011,
Pubmed
Jiang,
Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway.
2005,
Pubmed
Jung,
Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease.
2014,
Pubmed
Knaapen,
Obesity, non-alcoholic fatty liver disease, and atherothrombosis: a role for the intestinal microbiota?
2013,
Pubmed
Kudolo,
The effect of 3-month ingestion of Ginkgo biloba extract on pancreatic beta-cell function in response to glucose loading in normal glucose tolerant individuals.
2000,
Pubmed
Kudolo,
The effect of the ingestion of Ginkgo biloba extract (EGb 761) on the pharmacokinetics of metformin in non-diabetic and type 2 diabetic subjects--a double blind placebo-controlled, crossover study.
2006,
Pubmed
Liu,
Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma cells via a novel pathway involving AMP-activated protein kinase.
2007,
Pubmed
Makki,
Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines.
2013,
Pubmed
Oliveira,
Neuromodulatory property of standardized extract Ginkgo biloba L. (EGb 761) on memory: behavioral and molecular evidence.
2009,
Pubmed
Oliveira,
Long-term treatment with standardized extract of Ginkgo biloba L. enhances the conditioned suppression of licking in rats by the modulation of neuronal and glial cell function in the dorsal hippocampus and central amygdala.
2013,
Pubmed
Rasmussen,
Adiponectin receptors in human adipose tissue: effects of obesity, weight loss, and fat depots.
2006,
Pubmed
Rocha,
Inflammatory concepts of obesity.
2011,
Pubmed
Stumvoll,
Type 2 diabetes: principles of pathogenesis and therapy.
2005,
Pubmed
Tanaka,
[Effects of the flavonoid fraction from Ginkgo biloba extract on the postprandial blood glucose elevation in rats].
2004,
Pubmed
Tanti,
Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation.
2009,
Pubmed
Tateya,
Recent advances in obesity-induced inflammation and insulin resistance.
2013,
Pubmed
Telles,
Lateral hypothalamic serotonin is not stimulated during central leptin hypophagia.
2013,
Pubmed
Vanasse,
Stroke and cardiovascular morbidity and mortality associated with rosiglitazone use in elderly diabetic patients.
2009,
Pubmed
Yamaguchi,
Adiponectin inhibits Toll-like receptor family-induced signaling.
2005,
Pubmed
Yamashita,
Depot-specific modulation of adipokine levels in rat adipose tissue by diet-induced obesity: the effect of aerobic training and energy restriction.
2010,
Pubmed
Yang,
Dietary chickpeas reverse visceral adiposity, dyslipidaemia and insulin resistance in rats induced by a chronic high-fat diet.
2007,
Pubmed
Yoshikawa,
Ginkgo biloba leaf extract: review of biological actions and clinical applications.
1999,
Pubmed
Zanuto,
Melatonin improves insulin sensitivity independently of weight loss in old obese rats.
2013,
Pubmed
Zeng,
Biosynthesis pathways of ginkgolides.
2013,
Pubmed
Zhou,
Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells.
2011,
Pubmed
van Exel,
Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study.
2002,
Pubmed
