ECB-ART-47649
Bioorg Med Chem
2002 Jun 01;106:1961-6. doi: 10.1016/s0968-0896(02)00006-8.
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Linckosides A and B, two new neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata.
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Two new steroid glycosides, named linckosides A and B, were isolated from the Okinawan starfish Linckia laevigata, and their stereostructures were elucidated by spectroscopic methods and chemical derivatization. Each of them possesses two monosaccharide units at C-3 and C-29 of a polyhydroxylated steroid aglycon. These steroid glycosides showed not only notable neuritogenic activity against PC12 cells but also significant synergistic effects on the NGF-induced neuronal differentiation of PC12 cells. Linckoside B showed higher activities than those of linckoside A, though the structural difference is only the kind of a sugar.
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