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Proc Natl Acad Sci U S A
1981 Jul 01;787:4156-60. doi: 10.1073/pnas.78.7.4156.
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Complete amino acid sequence of beta-tubulin from porcine brain.
Krauhs E
,
Little M
,
Kempf T
,
Hofer-Warbinek R
,
Ade W
,
Ponstingl H
.
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The primary structure of porcine brain beta-tubulin was determined by automated and manual Edman degradation of six sets of overlapping peptides. The protein consists of 445 amino acid residues and has a minimum of six positions that are heterogeneous, indicating at least two beta-tubulins in porcine brain. Comparison of the optimally aligned sequences of alpha-tubulin and beta-tubulin indicates that 41% of their primary structures are identical. A region rich in glycyl residues is similar both in sequence and predicted secondary structure to the phosphate binding loop of several nucleotide binding enzymes. beta-Tubulin contains a highly acidic COOH-terminal region that resembles the NH2-terminus of troponin T.
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