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Trials
2017 Mar 04;181:99. doi: 10.1186/s13063-017-1785-y.
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Effectiveness of deep versus moderate muscle relaxation during laparoscopic donor nephrectomy in enhancing postoperative recovery: study protocol for a randomized controlled study.
Bruintjes MH
,
Braat AE
,
Dahan A
,
Scheffer GJ
,
Hilbrands LB
,
d'Ancona FC
,
Donders RA
,
van Laarhoven CJ
,
Warlé MC
.
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BACKGROUND: Postoperative recovery after live donor nephrectomy is largely determined by the consequences of postoperative pain and analgesia consumptions. The use of deep neuromuscular blockade has been shown to reduce postoperative pain scores after laparoscopic surgery. In this study, we will investigate whether deep neuromuscular blockade also improves the early quality of recovery after live donor nephrectomy.
METHODS: The RELAX-study is a phase IV, multicenter, double-blinded, randomized controlled trial, in which 96 patients, scheduled for living donor nephrectomy, will be randomized into two groups: one with deep and one with moderate neuromuscular blockade. Deep neuromuscular blockade is defined as a post-tetanic count of 1-2. Our primary outcome measurement will be the Quality of Recovery-40 questionnaire (overall score) at 24 h after extubation.
DISCUSSION: This study is, to our knowledge, the first randomized study to assess the effectiveness of deep neuromuscular blockade during laparoscopic donor nephrectomy in enhancing postoperative recovery. The study findings may also be applicable for other laparoscopic procedures.
TRIAL REGISTRATION: clinicaltrials.gov, NCT02838134 . Registered on 29 June 2016.
Asakura,
The Effect of Preoperative Oral Carbohydrate or Oral Rehydration Solution on Postoperative Quality of Recovery: A Randomized, Controlled Clinical Trial.
2015, Pubmed
Asakura,
The Effect of Preoperative Oral Carbohydrate or Oral Rehydration Solution on Postoperative Quality of Recovery: A Randomized, Controlled Clinical Trial.
2015,
Pubmed
Bargman,
Randomized trial of laparoscopic donor nephrectomy with and without hand assistance.
2006,
Pubmed
Branco,
A comparison of hand-assisted and pure laparoscopic techniques in live donor nephrectomy.
2008,
Pubmed
De Oliveira,
A dose-ranging study of the effect of transversus abdominis block on postoperative quality of recovery and analgesia after outpatient laparoscopy.
2011,
Pubmed
De Oliveira,
Systemic lidocaine to improve quality of recovery after laparoscopic bariatric surgery: a randomized double-blinded placebo-controlled trial.
2014,
Pubmed
Greco,
Enhanced recovery program in colorectal surgery: a meta-analysis of randomized controlled trials.
2014,
Pubmed
Gupta,
Laparoendoscopic single-site donor nephrectomy (LESS-DN) versus standard laparoscopic donor nephrectomy.
2016,
Pubmed
Gustafsson,
Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS(®)) Society recommendations.
2013,
Pubmed
Klop,
Can right-sided hand-assisted retroperitoneoscopic donor nephrectomy be advocated above standard laparoscopic donor nephrectomy: a randomized pilot study.
2014,
Pubmed
Lee,
Type of anaesthesia and patient quality of recovery: a randomized trial comparing propofol-remifentanil total i.v. anaesthesia with desflurane anaesthesia.
2015,
Pubmed
Martini,
Evaluation of surgical conditions during laparoscopic surgery in patients with moderate vs deep neuromuscular block.
2014,
Pubmed
Myles,
Validity and reliability of a postoperative quality of recovery score: the QoR-40.
2000,
Pubmed
Myles,
Minimal Clinically Important Difference for Three Quality of Recovery Scales.
2016,
Pubmed
Myles,
Development and psychometric testing of a quality of recovery score after general anesthesia and surgery in adults.
1999,
Pubmed
Rahangdale,
The effects of perineural versus intravenous dexamethasone on sciatic nerve blockade outcomes: a randomized, double-blind, placebo-controlled study.
2014,
Pubmed
Serrano,
Evolution of Living Donor Nephrectomy at a Single Center: Long-term Outcomes With 4 Different Techniques in Greater Than 4000 Donors Over 50 Years.
2016,
Pubmed
Waits,
Building the case for enhanced recovery protocols in living kidney donors.
2015,
Pubmed
Warlé,
Low-pressure pneumoperitoneum during laparoscopic donor nephrectomy to optimize live donors' comfort.
2013,
Pubmed
Wilson,
Laparoscopic versus open nephrectomy for live kidney donors.
2011,
Pubmed
Özdemir-van Brunschot,
Comparison of the effectiveness of low pressure pneumoperitoneum with profound muscle relaxation during laparoscopic donor nephrectomy to optimize the quality of recovery during the early post-operative phase: study protocol for a randomized controlled clinical trial.
2015,
Pubmed
Özdemir-van Brunschot,
What is the evidence for the use of low-pressure pneumoperitoneum? A systematic review.
2016,
Pubmed
