Romano G , Almeida M , Varela Coelho A , Cutignano A , Gonçalves LG , Hansen E , Khnykin D , Mass T , Ramšak A , Rocha MS , Silva TH , Sugni M , Ballarin L , Genevière AM .

16203 European Cooperation in Science and Technology

	Figure 1. The demosponge Smenospongia aurea (left) and Aplysina fistularis (right). Photo by Joseph Pawlik (https://spongeguide.uncw.edu/, accessed on 13 February 2022).
	Figure 2. Proportion of different bioactivity associated to sponge-derived MNP, according to data in Table S1.
	Figure 3. Renieramycin E (1) and ecteinascidin-743 (2).
	Figure 4. Smenamide A; (3) smenamide B (4).
	Figure 5. Aplysinopsin.
	Figure 6. Proportion of different bioactivity associated to cnidarian-derived MNP, according to data in Table S2.
	Figure 7. Fuscoside E (6); 11-epi-sinulariolide acetate (7); sarcophine (8); pukalide (9); cladidiol (10).
	Figure 8. Protoxenicin A (11); sinularone I (12).
	Figure 9. Proportion of different bioactivity associated to mollusc-derived MNP, according to data in Table S3.
	Figure 10. Lignarenone B (13) and dolastatin 10 (14).
	Figure 11. The sea hare Dolabella auricularia. (Photo by Dr. Ernesto Mollo.)
	Figure 12. The gastropod Conus textile. (Courtesy of Dr. Ernesto Mollo.)
	Figure 13. The sea urchin Paracentrotus lividus (left) and the sea star Echinaster sepositus (right) (photo by Federico Betti).
	Figure 14. Proportion of different bioactivity associated to echinoderm-derived MNPs, according to data in Table S4.
	Figure 15. Echinochrome A (15); spinochrome E (16).
	Figure 16. The ascidians Ciona intestinalis (left) and Botryllus schlosseri (right).
	Figure 17. Proportion of different bioactivity associated to tunicate-derived MNP, according to data in Table S5.
	Figure 18. Didemnin B (17) and plitidepsin (18).
	Figure 19. Metabolomics workflow for marine biodiscovery.
	Figure 20. Number of papers using metabolomic approaches in marine invertebrates by year (search was performed on March 2021 in PubMed limited to original papers that mention (((metabolomic OR “metabolic profile”) AND (“marine invertebrate” OR echinoderm OR cnidarian OR mollusc OR sponge OR tunicate))) or (((metabolomic OR “metabolic profile”) AND (“NMR” OR “Nuclear Magnetic Resonance”) AND (“marine invertebrate” OR echinoderm OR cnidarian OR mollusc OR sponge OR tunicate))) or (((metabolomic OR “metabolic profile”) AND (“mass spectrometry” OR “LC-MS” OR “GC-MS” OR “MS”) AND (“marine invertebrate” OR echinoderm OR cnidarian OR mollusc OR sponge OR tunicate))) in the title, abstract or keyword).

Adrian, Novel marine-derived anti-cancer agents. 2007, Pubmed

Adrian, Novel marine-derived anti-cancer agents. 2007, Pubmed
Agafonova, Evaluation of effects of histochrome and mexidol on structural and functional characteristics of the brain in senescence-accelerated OXYS rats by magnetic resonance imaging. 2011, Pubmed
Agafonova, Assessment of Nephroprotective Potential of Histochrome during Induced Arterial Hypertension. 2015, Pubmed
Ageenko, Pigment cell differentiation in sea urchin blastula-derived primary cell cultures. 2014, Pubmed , Echinobase
Alonso-Álvarez, Plitidepsin: design, development, and potential place in therapy. 2017, Pubmed
Amberg, NMR and MS Methods for Metabolomics. 2017, Pubmed
Aminin, 1,4-Naphthoquinones: Some Biological Properties and Application. 2020, Pubmed
Anderson, Distribution of spinochrome pigments in echinoids. 1969, Pubmed , Echinobase
Anufriev VPh, Synthesis of some hydroxynaphthazarins and their cardioprotective effects under ischemia-reperfusion in vivo. 1998, Pubmed
Atanasov, Natural products in drug discovery: advances and opportunities. 2021, Pubmed
Atanasov, Discovery and resupply of pharmacologically active plant-derived natural products: A review. 2015, Pubmed
Ayuningrum, Tunicate-associated bacteria show a great potential for the discovery of antimicrobial compounds. 2019, Pubmed
Azumi, Halocyamines: novel antimicrobial tetrapeptide-like substances isolated from the hemocytes of the solitary ascidian Halocynthia roretzi. 1990, Pubmed
Bahrami, Acetylated Triterpene Glycosides and Their Biological Activity from Holothuroidea Reported in the Past Six Decades. 2016, Pubmed , Echinobase
Ballarin, Oxidative stress induces cytotoxicity during rejection reaction in the compound ascidian Botryllus schlosseri. 2002, Pubmed
Barghi, High conopeptide diversity in Conus tribblei revealed through analysis of venom duct transcriptome using two high-throughput sequencing platforms. 2015, Pubmed
Barros, In vitro bioactivity studies of ceramic structures isolated from marine sponges. 2016, Pubmed
Bauman, Genome mining methods to discover bioactive natural products. 2021, Pubmed
Benedetto, Production, characterization and biocompatibility of marine collagen matrices from an alternative and sustainable source: the sea urchin Paracentrotus lividus. 2014, Pubmed , Echinobase
Betancur, Marine Actinobacteria as a source of compounds for phytopathogen control: An integrative metabolic-profiling / bioactivity and taxonomical approach. 2017, Pubmed
Binnewerg, Marine biomaterials: Biomimetic and pharmacological potential of cultivated Aplysina aerophoba marine demosponge. 2020, Pubmed
Bjørn-Yoshimoto, Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research. 2020, Pubmed
Blunt, Marine natural products. 2018, Pubmed
Bo, Isolation and identification of chitin in the black coral Parantipathes larix (Anthozoa: Cnidaria). 2012, Pubmed
Bose, Production of N-acyl homoserine lactones by the sponge-associated marine actinobacteria Salinispora arenicola and Salinispora pacifica. 2017, Pubmed
Brasseur, The Roles of Spinochromes in Four Shallow Water Tropical Sea Urchins and Their Potential as Bioactive Pharmacological Agents. 2017, Pubmed , Echinobase
Buĭmov, [Effect of the bioantioxidant histochrome on myocardial injury in reperfusion therapy on patients with myocardial infarction]. 2002, Pubmed
Bumpus, A proteomics approach to discovering natural products and their biosynthetic pathways. 2009, Pubmed
Cantrell, Mass Spectrometry-Based Integration and Expansion of the Chemical Diversity Harbored Within a Marine Sponge. 2019, Pubmed
Capadona, Stimuli-responsive polymer nanocomposites inspired by the sea cucumber dermis. 2008, Pubmed , Echinobase
Cappello, From Life in the Sea to the Clinic: The Marine Drugs Approved and under Clinical Trial. 2021, Pubmed
Carballeira, Novel Very Long-Chain α-Methoxylated Δ5,9 Fatty Acids from the Sponge Asteropus niger Are Effective Inhibitors of Topoisomerases IB. 2016, Pubmed
Carroll, Marine natural products. 2019, Pubmed
Carroll, Marine natural products. 2020, Pubmed , Echinobase
Carvalho, Marine collagen-chitosan-fucoidan cryogels as cell-laden biocomposites envisaging tissue engineering. 2020, Pubmed
Casertano, The Ascidian-Derived Metabolites with Antimicrobial Properties. 2020, Pubmed
Cha, Development of bioadhesives from marine mussels. 2008, Pubmed
Chen, Biological and Chemical Diversity of Ascidian-Associated Microorganisms. 2018, Pubmed
Cheng, Isolation of Petrocidin A, a New Cytotoxic Cyclic Dipeptide from the Marine Sponge-Derived Bacterium Streptomyces sp. SBT348. 2017, Pubmed
Choi, Highly purified mussel adhesive protein to secure biosafety for in vivo applications. 2014, Pubmed
Chollet, Fucoidans in Nanomedicine. 2016, Pubmed , Echinobase
Ciavatta, Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance. 2017, Pubmed
Citkowska, Possibilities of Fucoidan Utilization in the Development of Pharmaceutical Dosage Forms. 2019, Pubmed , Echinobase
Clancy, Marine Bioinspired Underwater Contact Adhesion. 2016, Pubmed
Clare, Antisettlement and Narcotic Action of Analogues of Diterpene Marine Natural Product Antifoulants from Octocorals. 1999, Pubmed
Clarke, Osteogenic cell response to 3-D hydroxyapatite scaffolds developed via replication of natural marine sponges. 2016, Pubmed
Coll, Structures and possible functions of epoxypukalide and pukalide : Diterpenes associated with eggs of sinularian soft corals (Cnidaria, Anthozoa, Octocorallia, Alcyonacea, Alcyoniidae). 1989, Pubmed
Conkling, Breakthrough in Marine Invertebrate Cell Culture: Sponge Cells Divide Rapidly in Improved Nutrient Medium. 2019, Pubmed
Cooper, Corals and their potential applications to integrative medicine. 2014, Pubmed
Cooper, Diving for drugs: tunicate anticancer compounds. 2012, Pubmed
Cruz, On the Mechanism of Action of Dragmacidins I and J, Two New Representatives of a New Class of Protein Phosphatase 1 and 2A Inhibitors. 2018, Pubmed
Cunningham, Hydroxyapatite bone substitutes developed via replication of natural marine sponges. 2010, Pubmed
Cutignano, First biosynthetic evidence on the phenyl-containing polyketides of the marine mollusc Scaphander lignarius. 2008, Pubmed
Cutignano, Biosynthesis and cellular localization of functional polyketides in the gastropod mollusc Scaphander lignarius. 2012, Pubmed
Cutignano, Development and Application of a Novel SPE-Method for Bioassay-Guided Fractionation of Marine Extracts. 2015, Pubmed
D'Ambra, A Review of Toxins from Cnidaria. 2020, Pubmed
Day, Osteogenic Potential of Human Umbilical Cord Mesenchymal Stem Cells on Coralline Hydroxyapatite/Calcium Carbonate Microparticles. 2018, Pubmed
de Caralt, Cell culture from sponges: pluripotency and immortality. 2007, Pubmed
Demeyer, Inter- and intra-organ spatial distributions of sea star saponins by MALDI imaging. 2015, Pubmed , Echinobase
de Souza, Bromopyrrole Alkaloid Inhibitors of the Proteasome Isolated from a Dictyonella sp. Marine Sponge Collected at the Amazon River Mouth. 2018, Pubmed
Domingues, The potential of cellulose nanocrystals in tissue engineering strategies. 2014, Pubmed
Dona, Precision high-throughput proton NMR spectroscopy of human urine, serum, and plasma for large-scale metabolic phenotyping. 2014, Pubmed
Dou, Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts. 2019, Pubmed
Dugan, Oriented surfaces of adsorbed cellulose nanowhiskers promote skeletal muscle myogenesis. 2013, Pubmed
Dunlop, Towards the scalable isolation of cellulose nanocrystals from tunicates. 2020, Pubmed
Dutertre, Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. 2013, Pubmed
Dwivedi, Marine Antithrombotics. 2020, Pubmed
Ehrlich, Discovery of chitin in skeletons of non-verongiid Red Sea demosponges. 2018, Pubmed
Ehrlich, Three-dimensional chitin-based scaffolds from Verongida sponges (Demospongiae: Porifera). Part II: Biomimetic potential and applications. 2010, Pubmed
Ehrlich, Arrested in Glass: Actin within Sophisticated Architectures of Biosilica in Sponges. 2022, Pubmed
Elsayed, Metabolomic profiling and biological investigation of the marine sponge-derived bacterium Rhodococcus sp. UA13. 2018, Pubmed
Elvin, Synthesis and properties of crosslinked recombinant pro-resilin. 2005, Pubmed
Exposito, Cloning and sequencing of a Porifera partial cDNA coding for a short-chain collagen. 1990, Pubmed
Fassini, Diverse and Productive Source of Biopolymer Inspiration: Marine Collagens. 2021, Pubmed
Fedders, A reverse search for antimicrobial peptides in Ciona intestinalis: identification of a gene family expressed in hemocytes and evaluation of activity. 2008, Pubmed
Fedders, An exceptional salt-tolerant antimicrobial peptide derived from a novel gene family of haemocytes of the marine invertebrate Ciona intestinalis. 2008, Pubmed
Fedders, The antimicrobial peptide Ci-MAM-A24 is highly active against multidrug-resistant and anaerobic bacteria pathogenic for humans. 2010, Pubmed
Fedoreyev, Antiviral and Antioxidant Properties of Echinochrome A. 2018, Pubmed , Echinobase
Ferrario, Marine-derived collagen biomaterials from echinoderm connective tissues. 2017, Pubmed , Echinobase
Ferrario, From Food Waste to Innovative Biomaterial: Sea Urchin-Derived Collagen for Applications in Skin Regenerative Medicine. 2020, Pubmed , Echinobase
Fidler, Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues. 2017, Pubmed
Flaig, In Vivo Analysis of the Biocompatibility and Immune Response of Jellyfish Collagen Scaffolds and its Suitability for Bone Regeneration. 2020, Pubmed
Flammang, Echinoderm adhesive secretions: from experimental characterization to biotechnological applications. 2005, Pubmed , Echinobase
Fontaine, Biocompatibility of echinoderm skeleton with mammalian cells in vitro: preliminary evidence. 1981, Pubmed , Echinobase
Fu, Discovery Methodology of Novel Conotoxins from Conus Species. 2018, Pubmed
Gauglitz, Combined gene and stem cell therapy for cutaneous wound healing. 2011, Pubmed
Gerhart, Chemical ecology and the search for marine antifoulants : Studies of a predator-prey symbiosis. 1988, Pubmed
Glaser, A renaissance in marine pharmacology: from preclinical curiosity to clinical reality. 2009, Pubmed
Goh, Collagenous Extracellular Matrix Biomaterials for Tissue Engineering: Lessons from the Common Sea Urchin Tissue. 2017, Pubmed , Echinobase
Green, Marine Structural Biomaterials in Medical Biomimicry. 2015, Pubmed
Grkovic, National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library. 2020, Pubmed
Guillemin, Comparison of coral resorption and bone apposition with two natural corals of different porosities. 1989, Pubmed
Guillen, Marine natural products from zoantharians: bioactivity, biosynthesis, systematics, and ecological roles. 2020, Pubmed
Harvey, The re-emergence of natural products for drug discovery in the genomics era. 2015, Pubmed
Harvey, Natural products in drug discovery. 2008, Pubmed
Haug, Antibacterial activity in Strongylocentrotus droebachiensis (Echinoidea), Cucumaria frondosa (Holothuroidea), and Asterias rubens (Asteroidea). 2002, Pubmed , Echinobase
Hennebert, Sea star tenacity mediated by a protein that fragments, then aggregates. 2014, Pubmed , Echinobase
Hennebert, Characterisation of the carbohydrate fraction of the temporary adhesive secreted by the tube feet of the sea star Asterias rubens. 2011, Pubmed , Echinobase
Hennebert, An integrated transcriptomic and proteomic analysis of sea star epidermal secretions identifies proteins involved in defense and adhesion. 2015, Pubmed , Echinobase
Hickey, Cellulose Biomaterials for Tissue Engineering. 2019, Pubmed
Higashi, Functional chondroitin sulfate from Enteroctopus dofleini containing a 3-O-sulfo glucuronic acid residue. 2015, Pubmed , Echinobase
Hossain, Northern Sea Cucumber (Cucumaria frondosa): A Potential Candidate for Functional Food, Nutraceutical, and Pharmaceutical Sector. 2020, Pubmed , Echinobase
Hou, In vitro antioxidant and antimicrobial activities, and in vivo anti-inflammatory activity of crude and fractionated PHNQs from sea urchin (Evechinus chloroticus). 2020, Pubmed , Echinobase
Hoyer, Jellyfish collagen scaffolds for cartilage tissue engineering. 2014, Pubmed
Hu, Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012. 2015, Pubmed
Hwang, Recombinant mussel adhesive protein Mgfp-5 as cell adhesion biomaterial. 2007, Pubmed
Ivanchina, Steroid glycosides from marine organisms. 2011, Pubmed
Jang, Halocidin: a new antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium. 2002, Pubmed
Jeon, Natural healing-inspired collagen-targeting surgical protein glue for accelerated scarless skin regeneration. 2017, Pubmed
Jeon, Rapidly light-activated surgical protein glue inspired by mussel adhesion and insect structural crosslinking. 2015, Pubmed
Jeong, Echinochrome A protects mitochondrial function in cardiomyocytes against cardiotoxic drugs. 2014, Pubmed , Echinobase
Jeong, Echinochrome a increases mitochondrial mass and function by modulating mitochondrial biogenesis regulatory genes. 2014, Pubmed , Echinobase
Johnson, Open-access metabolomics databases for natural product research: present capabilities and future potential. 2015, Pubmed
Jorfi, Progress towards biocompatible intracortical microelectrodes for neural interfacing applications. 2015, Pubmed
Jouiaei, Ancient Venom Systems: A Review on Cnidaria Toxins. 2015, Pubmed
Kariya, Structure of fucose branches in the glycosaminoglycan from the body wall of the sea cucumber Stichopus japonicus. 1997, Pubmed , Echinobase
Kariya, Occurrence of chondroitin sulfate E in glycosaminoglycan isolated from the body wall of sea cucumber Stichopus japonicus. 1990, Pubmed , Echinobase
Khrunyk, Progress in Modern Marine Biomaterials Research. 2020, Pubmed
Kim, Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat. 2019, Pubmed , Echinobase
Kim, A Novel Atypical PKC-Iota Inhibitor, Echinochrome A, Enhances Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells. 2018, Pubmed , Echinobase
Kim, Echinochrome A regulates phosphorylation of phospholamban Ser16 and Thr17 suppressing cardiac SERCA2A Ca²⁺ reuptake. 2015, Pubmed , Echinobase
Kim, Development of a complex bone tissue culture system based on cellulose nanowhisker mechanical strain. 2014, Pubmed
Kitagawa, A novel pentasaccharide sequence GlcA(3-sulfate)(beta1-3)GalNAc(4-sulfate)(beta1-4)(Fuc alpha1-3)GlcA(beta1-3)GalNAc(4-sulfate) in the oligosaccharides isolated from king crab cartilage chondroitin sulfate K and its differential susceptibility to chondroitinases and hyaluronidase. 1997, Pubmed
Klinger, Express Method for Isolation of Ready-to-Use 3D Chitin Scaffolds from Aplysina archeri (Aplysineidae: Verongiida) Demosponge. 2019, Pubmed
Komori, Toxins from the starfish Acanthaster planci and Asterina pectinifera. 1997, Pubmed , Echinobase
Kord Forooshani, Recent approaches in designing bioadhesive materials inspired by mussel adhesive protein. 2017, Pubmed
Kovalchuk, Naturally Drug-Loaded Chitin: Isolation and Applications. 2019, Pubmed
Kunze, Brominated skeletal components of the marine demosponges, Aplysina cavernicola and Ianthella basta: analytical and biochemical investigations. 2013, Pubmed
Langasco, Natural collagenic skeleton of marine sponges in pharmaceutics: Innovative biomaterial for topical drug delivery. 2017, Pubmed
Lawrence, Bioactivity as an options value of sea cucumbers in the Egyptian Red Sea. 2010, Pubmed , Echinobase
Le, Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics. 2015, Pubmed
Leal, Trends in the discovery of new marine natural products from invertebrates over the last two decades--where and what are we bioprospecting? 2012, Pubmed , Echinobase
Leão, A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria. 2021, Pubmed
Lebedev, Echinochrome, a naturally occurring iron chelator and free radical scavenger in artificial and natural membrane systems. 2005, Pubmed
Lebedev, Antioxidant properties, autooxidation, and mutagenic activity of echinochrome a compared with its etherified derivative. 2001, Pubmed
Lebedev, Iron chelators and free radical scavengers in naturally occurring polyhydroxylated 1,4-naphthoquinones. 2008, Pubmed
Lee, Clavaspirin, an antibacterial and haemolytic peptide from Styela clava. 2001, Pubmed
Lee, Mussel-Inspired Adhesives and Coatings. 2011, Pubmed
Lee, Styelins, broad-spectrum antimicrobial peptides from the solitary tunicate, Styela clava. 1997, Pubmed
Lefevre, Sea star-inspired recombinant adhesive proteins self-assemble and adsorb on surfaces in aqueous environments to form cytocompatible coatings. 2020, Pubmed , Echinobase
Lehrer, Natural Peptide antibiotics from tunicates: structures, functions and potential uses. 2003, Pubmed
Le Tourneau, Aplidine: a paradigm of how to handle the activity and toxicity of a novel marine anticancer poison. 2007, Pubmed
Li, Expression of antimicrobial peptides in coelomocytes and embryos of the green sea urchin (Strongylocentrotus droebachiensis). 2014, Pubmed , Echinobase
Li, Low-molecular-weight fucosylated glycosaminoglycan and its oligosaccharides from sea cucumber as novel anticoagulants: A review. 2021, Pubmed , Echinobase
Li, Strongylocins, novel antimicrobial peptides from the green sea urchin, Strongylocentrotus droebachiensis. 2008, Pubmed , Echinobase
Li, Identification and characterization of proteins involved in stolon adhesion in the highly invasive fouling ascidian Ciona robusta. 2019, Pubmed
Li, Diving into the world of marine 2,11-cyclized cembranoids: a summary of new compounds and their biological activities. 2020, Pubmed
Li, Centrocins: isolation and characterization of novel dimeric antimicrobial peptides from the green sea urchin, Strongylocentrotus droebachiensis. 2010, Pubmed , Echinobase
Liang, Self-Assembled Nanofibers for Strong Underwater Adhesion: The Trick of Barnacles. 2018, Pubmed
Liao, Cnidarian peptide neurotoxins: a new source of various ion channel modulators or blockers against central nervous systems disease. 2019, Pubmed
Lin, In vitro evaluation of natural marine sponge collagen as a scaffold for bone tissue engineering. 2011, Pubmed
Lin, A bacterial source for mollusk pyrone polyketides. 2013, Pubmed
Llorach-Pares, Meridianins and Lignarenone B as Potential GSK3β Inhibitors and Inductors of Structural Neuronal Plasticity. 2020, Pubmed
Lu, Various conotoxin diversifications revealed by a venomic study of Conus flavidus. 2014, Pubmed
Macha, Marine Skeletons: Towards Hard Tissue Repair and Regeneration. 2018, Pubmed
Machado, Omics-based natural product discovery and the lexicon of genome mining. 2017, Pubmed
Malyarenko, Effects of Polar Steroids from the Starfish Patiria (=Asterina) pectinifera in Combination with X-Ray Radiation on Colony Formation and Apoptosis Induction of Human Colorectal Carcinoma Cells. 2019, Pubmed , Echinobase
Malyarenko, Fucoidan from brown algae Fucus evanescens potentiates the anti-proliferative efficacy of asterosaponins from starfish Asteropsis carinifera in 2D and 3D models of melanoma cells. 2021, Pubmed , Echinobase
Martina, Developing macroporous bicontinuous materials as scaffolds for tissue engineering. 2005, Pubmed , Echinobase
Melotti, A Prototype Skin Substitute, Made of Recycled Marine Collagen, Improves the Skin Regeneration of Sheep. 2021, Pubmed , Echinobase
Menzel, Immunolocalization of clavanins in Styela clava hemocytes. 2002, Pubmed
Merquiol, Biotechnological Applications of Scyphomedusae. 2019, Pubmed
Mischenko, Echinamines A and B, first aminated hydroxynaphthazarins from the sea urchin Scaphechinus mirabilis. 2005, Pubmed , Echinobase
Mishchenko, Antiviral Potential of Sea Urchin Aminated Spinochromes against Herpes Simplex Virus Type 1. 2020, Pubmed , Echinobase
Mo, Interfibrillar stiffening of echinoderm mutable collagenous tissue demonstrated at the nanoscale. 2016, Pubmed , Echinobase
Mohamed, The Possible Hypoglycemic Mechanisms of Echinochrome. 2018, Pubmed , Echinobase
Mohamed, Mechanisms of echinochrome potency in modulating diabetic complications in liver. 2016, Pubmed , Echinobase
Moodie, Natural cholinesterase inhibitors from marine organisms. 2019, Pubmed
Müller, Application of cell culture for the production of bioactive compounds from sponges: synthesis of avarol by primmorphs from Dysidea avara. 2000, Pubmed
Müller, Formation of siliceous spicules in the marine demosponge Suberites domuncula. 2005, Pubmed
Mutsenko, 3D chitinous scaffolds derived from cultivated marine demosponge Aplysina aerophoba for tissue engineering approaches based on human mesenchymal stromal cells. 2017, Pubmed
Mutsenko, Novel chitin scaffolds derived from marine sponge Ianthella basta for tissue engineering approaches based on human mesenchymal stromal cells: Biocompatibility and cryopreservation. 2017, Pubmed
Nandi, In vitro and in vivo evaluation of the marine sponge skeleton as a bone mimicking biomaterial. 2015, Pubmed
Naruse, Acrosome reaction-related steroidal saponin, Co-ARIS, from the starfish induces structural changes in microdomains. 2010, Pubmed , Echinobase
Ne'eman, Sarcophine--a new toxin from the soft coral Sarcophyton glaucum (Alcyonaria). 1974, Pubmed
Neto, Synthetic and Marine-Derived Porous Scaffolds for Bone Tissue Engineering. 2018, Pubmed
Newman, Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. 2020, Pubmed
Nicklas, Preparation and characterization of marine sponge collagen nanoparticles and employment for the transdermal delivery of 17beta-estradiol-hemihydrate. 2009, Pubmed
NISHIBORI, Isolation of echinochrome A from the spines of the sea urchin, Stomopneustes variolaris (Lamarck). 1961, Pubmed , Echinobase
Oh, Tunicate-mimetic nanofibrous hydrogel adhesive with improved wet adhesion. 2015, Pubmed
Oh, Echinochrome A Reduces Colitis in Mice and Induces In Vitro Generation of Regulatory Immune Cells. 2019, Pubmed , Echinobase
Ooi, Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. 2000, Pubmed
Pallela, Biophysicochemical evaluation of chitosan-hydroxyapatite-marine sponge collagen composite for bone tissue engineering. 2012, Pubmed
Parisi, Marine spongin incorporation into Biosilicate® for tissue engineering applications: An in vivo study. 2020, Pubmed
Park, Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela clava tunics and Broussonetia kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats. 2019, Pubmed
Park, Echinochrome A Promotes Ex Vivo Expansion of Peripheral Blood-Derived CD34+ Cells, Potentially through Downregulation of ROS Production and Activation of the Src-Lyn-p110δ Pathway. 2019, Pubmed
Park, Therapeutic Cell Protective Role of Histochrome under Oxidative Stress in Human Cardiac Progenitor Cells. 2019, Pubmed , Echinobase
Paul, Chemical Ecology of Marine Sponges: New Opportunities through "-Omics". 2019, Pubmed
Pavão, Highly sulfated dermatan sulfates from Ascidians. Structure versus anticoagulant activity of these glycosaminoglycans. 1998, Pubmed
Pavão, Ascidian (Chordata-Tunicata) glycosaminoglycans: extraction, purification, biochemical, and spectroscopic analysis. 2015, Pubmed
Pénez, Antifouling properties of simple indole and purine alkaloids from the Mediterranean gorgonian Paramuricea clavata. 2011, Pubmed
Pereira, Have marine natural product drug discovery efforts been productive and how can we improve their efficiency? 2019, Pubmed
Pérez-Matos, Bacterial diversity associated with the Caribbean tunicate Ecteinascidia turbinata. 2007, Pubmed
Plazzi, Towards a molecular phylogeny of Mollusks: bivalves' early evolution as revealed by mitochondrial genes. 2010, Pubmed
Pomin, Galactosaminoglycans: Medical Applications and Drawbacks. 2019, Pubmed , Echinobase
Pomin, Fucanomics and galactanomics: marine distribution, medicinal impact, conceptions, and challenges. 2012, Pubmed
Pomin, Structure, biology, evolution, and medical importance of sulfated fucans and galactans. 2008, Pubmed , Echinobase
Pomin, Holothurian fucosylated chondroitin sulfate. 2014, Pubmed , Echinobase
Pomin, Review: an overview about the structure-function relationship of marine sulfated homopolysaccharides with regular chemical structures. 2009, Pubmed , Echinobase
Potts, Developments in marine invertebrate primary culture reveal novel cell morphologies in the model bivalve Crassostrea gigas. 2020, Pubmed
Pozzolini, Production, Characterization and Biocompatibility Evaluation of Collagen Membranes Derived from Marine Sponge Chondrosia reniformis Nardo, 1847. 2018, Pubmed
Prajatelistia, Tunicate-Inspired Gallic Acid/Metal Ion Complex for Instant and Efficient Treatment of Dentin Hypersensitivity. 2016, Pubmed
Qi, Steroids from the South China Sea gorgonian Subergorgia suberosa. 2010, Pubmed
Qi, Antifouling Compounds from Marine Invertebrates. 2017, Pubmed
Ramesh, Marine Natural Products from Tunicates and Their Associated Microbes. 2021, Pubmed
Rath, Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743. 2011, Pubmed
Rinehart, Didemnins: antiviral and antitumor depsipeptides from a caribbean tunicate. 1981, Pubmed
Robinson, Conotoxin gene superfamilies. 2014, Pubmed
Rojko, Pore formation by actinoporins, cytolysins from sea anemones. 2016, Pubmed
Sagar, Antiviral lead compounds from marine sponges. 2010, Pubmed
Sakai, Structure--activity relationships of the didemnins. 1996, Pubmed
Sanandiya, Tunichrome-inspired pyrogallol functionalized chitosan for tissue adhesion and hemostasis. 2019, Pubmed
Sayed, Echinochrome pigment as novel therapeutic agent against experimentally - induced gastric ulcer in rats. 2018, Pubmed , Echinobase
Scherlach, Mining and unearthing hidden biosynthetic potential. 2021, Pubmed
Schillaci, Paracentrin 1, a synthetic antimicrobial peptide from the sea-urchin Paracentrotus lividus, interferes with staphylococcal and Pseudomonas aeruginosa biofilm formation. 2014, Pubmed , Echinobase
Schöffski, Clinical impact of trabectedin (ecteinascidin-743) in advanced/metastatic soft tissue sarcoma. 2008, Pubmed
Schofield, Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743. 2015, Pubmed
Schönherr, Decorin-type I collagen interaction. Presence of separate core protein-binding domains. 1995, Pubmed
Schröder, Silicate modulates the cross-talk between osteoblasts (SaOS-2) and osteoclasts (RAW 264.7 cells): inhibition of osteoclast growth and differentiation. 2012, Pubmed
Schubert, Naturally Prefabricated Marine Biomaterials: Isolation and Applications of Flat Chitinous 3D Scaffolds from Ianthella labyrinthus (Demospongiae: Verongiida). 2019, Pubmed
Shaala, New Source of 3D Chitin Scaffolds: The Red Sea Demosponge Pseudoceratina arabica (Pseudoceratinidae, Verongiida). 2019, Pubmed
Shapo, Antimicrobial activity in the common seawhip, Leptogorgia virgulata (Cnidaria: Gorgonaceae). 2007, Pubmed
Sheehy, The Incorporation of Marine Coral Microparticles into Collagen-Based Scaffolds Promotes Osteogenesis of Human Mesenchymal Stromal Cells via Calcium Ion Signalling. 2020, Pubmed
Shestak, Preparative production of spinochrome E, a pigment of different sea urchin species. 2014, Pubmed , Echinobase
Singh, The synthesis of spinochromes A, C, D, and E. 1965, Pubmed
Sivonen, Cyanobactins-ribosomal cyclic peptides produced by cyanobacteria. 2010, Pubmed
Smith, Echinoderm immunity. 2010, Pubmed , Echinobase
Snyder, Untargeted metabolomics from biological sources using ultraperformance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS). 2013, Pubmed
Solstad, Novel Antimicrobial Peptides EeCentrocins 1, 2 and EeStrongylocin 2 from the Edible Sea Urchin Echinus esculentus Have 6-Br-Trp Post-Translational Modifications. 2016, Pubmed , Echinobase
Song, Cellulose film regenerated from Styela clava tunics have biodegradability, toxicity and biocompatibility in the skin of SD rats. 2014, Pubmed
Song, Selenium-loaded cellulose film derived from Styela clava tunic accelerates the healing process of cutaneous wounds in streptozotocin-induced diabetic Sprague-Dawley rats. 2018, Pubmed
Song, Collagen scaffolds derived from a marine source and their biocompatibility. 2006, Pubmed
Spinello, Antimicrobial and Antibiofilm Activity of a Recombinant Fragment of β-Thymosin of Sea Urchin Paracentrotus lividus. 2018, Pubmed , Echinobase
Stabili, Antibacterial activity in the coelomocytes of the sea urchin Paracentrotus lividus. 1996, Pubmed , Echinobase
Stonik, Asterosaponins: Structures, Taxonomic Distribution, Biogenesis and Biological Activities. 2020, Pubmed , Echinobase
Sunagawa, Identification and gene expression analysis of a taxonomically restricted cysteine-rich protein family in reef-building corals. 2009, Pubmed
Swatschek, Marine sponge collagen: isolation, characterization and effects on the skin parameters surface-pH, moisture and sebum. 2002, Pubmed
Swatschek, Microparticles derived from marine sponge collagen (SCMPs): preparation, characterization and suitability for dermal delivery of all-trans retinol. 2002, Pubmed
Taddei, Oxidation and inactivation of low molecular weight protein tyrosine phosphatase by the anticancer drug Aplidin. 2006, Pubmed
Tammam, Bioactive Steroids from the Red Sea Soft Coral Sinularia polydactyla. 2020, Pubmed
Taylor, New Perspectives in the Chemistry and Biochemistry of the Tunichromes and Related Compounds. 1997, Pubmed
Taylor, Styelin D, an extensively modified antimicrobial peptide from ascidian hemocytes. 2000, Pubmed
Teixeira, Sulfated fucans and a sulfated galactan from sea urchins as potent inhibitors of selectin-dependent hematogenous metastasis. 2018, Pubmed , Echinobase
Tello, Disruption in quorum-sensing systems and bacterial biofilm inhibition by cembranoid diterpenes isolated from the octocoral Eunicea knighti. 2012, Pubmed
Teta, A joint molecular networking study of a Smenospongia sponge and a cyanobacterial bloom revealed new antiproliferative chlorinated polyketides. 2019, Pubmed
Tianero, Localized production of defence chemicals by intracellular symbionts of Haliclona sponges. 2019, Pubmed
Tincu, Plicatamide, an antimicrobial octapeptide from Styela plicata hemocytes. 2003, Pubmed
Trotter, Towards a fibrous composite with dynamically controlled stiffness: lessons from echinoderms. 2000, Pubmed , Echinobase
Tsukimoto, Bacterial production of the tunicate-derived antitumor cyclic depsipeptide didemnin B. 2011, Pubmed
Urban-Gedamke, 3-D Culture of Marine Sponge Cells for Production of Bioactive Compounds. 2021, Pubmed
Urda, Protoxenicins A and B, Cytotoxic Long-Chain Acylated Xenicanes from the Soft Coral Protodendron repens. 2017, Pubmed
Ustyuzhanina, Structural analysis of holothurian fucosylated chondroitin sulfates: Degradation versus non-destructive approach. 2019, Pubmed , Echinobase
Van Soest, Global diversity of sponges (Porifera). 2012, Pubmed
Vasconcelos, The Sea as a Rich Source of Structurally Unique Glycosaminoglycans and Mimetics. 2017, Pubmed , Echinobase
Ventura, Cnidarian Primary Cell Culture as a Tool to Investigate the Effect of Thermal Stress at Cellular Level. 2018, Pubmed
Vessella, (Semi)-Synthetic Fucosylated Chondroitin Sulfate Oligo- and Polysaccharides. 2020, Pubmed
Viana, Nanoscale characterization of the temporary adhesive of the sea urchin Paracentrotus lividus. 2018, Pubmed , Echinobase
Viant, NMR-based metabolomics: a powerful approach for characterizing the effects of environmental stressors on organism health. 2003, Pubmed
Vieira, Structure of a fucose-branched chondroitin sulfate from sea cucumber. Evidence for the presence of 3-O-sulfo-beta-D-glucuronosyl residues. 1991, Pubmed , Echinobase
Villegas-Plazas, Variations in Microbial Diversity and Metabolite Profiles of the Tropical Marine Sponge Xestospongia muta with Season and Depth. 2019, Pubmed
Wägele, Opisthobranchia (Mollusca, Gastropoda) - more than just slimy slugs. Shell reduction and its implications on defence and foraging. 2005, Pubmed
Wang, Bioactive and biodegradable silica biomaterial for bone regeneration. 2014, Pubmed
Wang, Ascidian-Inspired Heparin-Mimetic Magnetic Nanoparticles with Potential for Application in Hemodialysis as Recycling Anticoagulants. 2020, Pubmed
Wang, Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies. 2019, Pubmed
Wang, The marine sponge-derived inorganic polymers, biosilica and polyphosphate, as morphogenetically active matrices/scaffolds for the differentiation of human multipotent stromal cells: potential application in 3D printing and distraction osteogenesis. 2014, Pubmed
Wang, Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. 2016, Pubmed
Weber, New porous biomaterials by replication of echinoderm skeletal microstructures. 1971, Pubmed , Echinobase
Wei, Hydrophobic enhancement of Dopa-mediated adhesion in a mussel foot protein. 2013, Pubmed
Wiens, Osteogenic potential of biosilica on human osteoblast-like (SaOS-2) cells. 2010, Pubmed
Williams, The Integration of Genome Mining, Comparative Genomics, and Functional Genetics for Biosynthetic Gene Cluster Identification. 2020, Pubmed
Wolfender, Accelerating Metabolite Identification in Natural Product Research: Toward an Ideal Combination of Liquid Chromatography-High-Resolution Tandem Mass Spectrometry and NMR Profiling, in Silico Databases, and Chemometrics. 2019, Pubmed
Xiao, Chemical synthesis of marine saponins. 2019, Pubmed , Echinobase
Xu, Bacterial biosynthesis and maturation of the didemnin anti-cancer agents. 2012, Pubmed
Yamagishi, Structure-Activity Relationship Study of the Neuritogenic Potential of the Glycan of Starfish Ganglioside LLG-3 (‡). 2015, Pubmed , Echinobase
Yang, Design of silk-like biomaterials inspired by mussel-adhesive protein. 2007, Pubmed
Yoon, Spinochrome D Attenuates Doxorubicin-Induced Cardiomyocyte Death via Improving Glutathione Metabolism and Attenuating Oxidative Stress. 2018, Pubmed , Echinobase
Zakirova, [Pharmacokinetics and clinical efficacy of histochrome in patients with acute myocardial infarction]. 1997, Pubmed
Zeng, Identifying adhesive components in a model tunicate. 2019, Pubmed
Zeng, Papillae revisited and the nature of the adhesive secreting collocytes. 2019, Pubmed
Zhan, Tunicate-Inspired Gallol Polymers for Underwater Adhesive: A Comparative Study of Catechol and Gallol. 2017, Pubmed
Zhao, cDNA cloning of three cecropin-like antimicrobial peptides (Styelins) from the tunicate, Styela clava. 1997, Pubmed
Żółtowska-Aksamitowska, First Report on Chitin in a Non-Verongiid Marine Demosponge: The Mycale euplectellioides Case. 2018, Pubmed
Żółtowska-Aksamitowska, The demosponge Pseudoceratina purpurea as a new source of fibrous chitin. 2018, Pubmed