Environ Toxicol 2008 Jun 01;233:387-92. doi: 10.1002/tox.20349.

Effects of bisphenol A on the embryonic development of sea urchin (Paracentrotus lividus).

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Bisphenol A (BPA), is one of the most important industrial chemicals synthesized for diverse applications. In this study, tests for embryotoxic and spermiotoxic effects of BPA were utilized in the sperms and embryos of the sea urchin Paracentrotus lividus. The sperm and eggs of sea urchins were exposed to increasing concentrations of BPA (300-3500 microg/L) under static conditions. The endpoints were successful sperm fertilization, larval malformations, developmental arrest, and embryonic/larval mortality. BPA concentration (300 microg/L) had spermiotoxic and embryotoxic effects on this species. A dose-response related reduction was observed in fertilization success and significant increases in the number of larvae with skeleton malformations at the pluteus stage when the sperms were exposed BPA. The embryotoxicity of BPA is concentration-dependent and significant growth reduction at the early life stages and an increase in larval malformations as skeleton deformities at the pluteus stage were observed. It can be concluded that BPA adversely affects the reproduction and embryonic developmental stages of the P. lividus and this is of great ecological importance due to the hazard at the population level.

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Genes referenced: LOC100887844