Majumdar S , Rio DC .

R01 GM048862 NIGMS NIH HHS , R35 GM118121 NIGMS NIH HHS , R01 GM097352 NIGMS NIH HHS , R01 GM061987 NIGMS NIH HHS , R01 GM104385 NIGMS NIH HHS

Adams, From sequence to phenotype: reverse genetics in Drosophila melanogaster. 2002, Pubmed

Adams, From sequence to phenotype: reverse genetics in Drosophila melanogaster. 2002, Pubmed
Adams, Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing. 2003, Pubmed
Adams, The alternative splicing factor PSI regulates P-element third intron splicing in vivo. 1997, Pubmed
Amarasinghe, An in vitro-selected RNA-binding site for the KH domain protein PSI acts as a splicing inhibitor element. 2001, Pubmed
Aravin, The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. 2007, Pubmed
Au, True reversal of Mu integration. 2004, Pubmed
Bachmann, The use of P-element transposons to generate transgenic flies. 2008, Pubmed
Beall, Drosophila IRBP/Ku p70 corresponds to the mutagen-sensitive mus309 gene and is involved in P-element excision in vivo. 1996, Pubmed
Beall, Drosophila P-element transposase is a novel site-specific endonuclease. 1997, Pubmed
Beall, Transposase makes critical contacts with, and is stimulated by, single-stranded DNA at the P element termini in vitro. 1998, Pubmed
Bellen, The Drosophila gene disruption project: progress using transposons with distinctive site specificities. 2011, Pubmed
Bellen, The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. 2004, Pubmed
Black, Mechanisms of alternative pre-messenger RNA splicing. 2003, Pubmed
Black, KP elements repress P-induced hybrid dysgenesis in Drosophila melanogaster. 1987, Pubmed
Blanchette, Global analysis of positive and negative pre-mRNA splicing regulators in Drosophila. 2005, Pubmed
Blanchette, Genome-wide analysis of alternative pre-mRNA splicing and RNA-binding specificities of the Drosophila hnRNP A/B family members. 2009, Pubmed
Blencowe, Alternative splicing: new insights from global analyses. 2006, Pubmed
Bourne, The GTPase superfamily: a conserved switch for diverse cell functions. 1990, Pubmed
Bourne, The GTPase superfamily: conserved structure and molecular mechanism. 1991, Pubmed
Boyd, Third-chromosome mutagen-sensitive mutants of Drosophila melanogaster. 1981, Pubmed
Brennecke, Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. 2007, Pubmed
Brennecke, An epigenetic role for maternally inherited piRNAs in transposon silencing. 2008, Pubmed
Burd, Conserved structures and diversity of functions of RNA-binding proteins. 1994, Pubmed
Burd, RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. 1994, Pubmed
Campagne, Structural determinants of specific DNA-recognition by the THAP zinc finger. 2010, Pubmed
Carlton, Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. 2007, Pubmed
Chain, Identification of a cis-acting sequence required for germ line-specific splicing of the P element ORF2-ORF3 intron. 1991, Pubmed
Chapman, The dynamic genome of Hydra. 2010, Pubmed
Chmiel, Distinct contributions of KH domains to substrate binding affinity of Drosophila P-element somatic inhibitor protein. 2006, Pubmed
Chow, Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus. 1992, Pubmed
Cooley, Insertional mutagenesis of the Drosophila genome with single P elements. 1988, Pubmed
Daniels, Hybrid dysgenesis in Drosophila simulans lines transformed with autonomous P elements. 1989, Pubmed
Daniels, Genetic transformation of Drosophila melanogaster with an autonomous P element: phenotypic and molecular analyses of long-established transformed lines. 1987, Pubmed
Dray, Homology requirements for targeting heterologous sequences during P-induced gap repair in Drosophila melanogaster. 1997, Pubmed
Dyda, The emerging diversity of transpososome architectures. 2012, Pubmed
Engels, The origin of P elements in Drosophila melanogaster. 1992, Pubmed
Engels, High-frequency P element loss in Drosophila is homolog dependent. 1990, Pubmed
Engels, Extrachromosomal control of mutability in Drosophila melanogaster. 1979, Pubmed
Engels, Long-range cis preference in DNA homology search over the length of a Drosophila chromosome. 1994, Pubmed
Engels, Invasions of P elements. 1997, Pubmed
Engels, P elements in Drosophila. 1996, Pubmed
Engels, The P family of transposable elements in Drosophila. 1983, Pubmed
Engels, Hybrid dysgenesis in Drosophila melanogaster: rules of inheritance of female sterility. 2007, Pubmed
Formosa, DNA synthesis dependent on genetic recombination: characterization of a reaction catalyzed by purified bacteriophage T4 proteins. 1986, Pubmed
Fugmann, Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex. 2000, Pubmed
Gasper, It takes two to tango: regulation of G proteins by dimerization. 2009, Pubmed
Gloor, Type I repressors of P element mobility. 1993, Pubmed
Hagemann, The implications of DNA transposons in the evolution of P elements in zebrafish (Danio rerio). 2006, Pubmed
Hagemann, Drosophila P transposons in the human genome? 2001, Pubmed
Haley, Impairment of cytotype regulation of P-element activity in Drosophila melanogaster by mutations in the Su(var)205 gene. 2005, Pubmed
Hammer, Homologs of Drosophila P transposons were mobile in zebrafish but have been domesticated in a common ancestor of chicken and human. 2005, Pubmed
Hammond, Mutations in the hrp48 gene, which encodes a Drosophila heterogeneous nuclear ribonucleoprotein particle protein, cause lethality and developmental defects and affect P-element third-intron splicing in vivo. 1997, Pubmed
Hellsten, The genome of the Western clawed frog Xenopus tropicalis. 2010, Pubmed
Hickman, Integrating prokaryotes and eukaryotes: DNA transposases in light of structure. 2010, Pubmed
Hiraizumi, Spontaneous recombination in Drosophila melanogaster males. 1971, Pubmed
Hummel, P-element mutagenesis. 2008, Pubmed
Ignjatovic, Structural basis of the interaction between P-element somatic inhibitor and U1-70k essential for the alternative splicing of P-element transposase. 2005, Pubmed
Jackson, Amplification of KP elements associated with the repression of hybrid dysgenesis in Drosophila melanogaster. 1988, Pubmed
Johnson-Schlitz, Multiple-pathway analysis of double-strand break repair mutations in Drosophila. 2007, Pubmed
Josse, Telomeric trans-silencing: an epigenetic repression combining RNA silencing and heterochromatin formation. 2007, Pubmed
Karess, Analysis of P transposable element functions in Drosophila. 1984, Pubmed
Karpen, Analysis of subtelomeric heterochromatin in the Drosophila minichromosome Dp1187 by single P element insertional mutagenesis. 1992, Pubmed
Kaufman, P element transposition in vitro proceeds by a cut-and-paste mechanism and uses GTP as a cofactor. 1992, Pubmed
Kaufman, Drosophila P element transposase recognizes internal P element DNA sequences. 1989, Pubmed
Keeler, Efficient gap repair in Drosophila melanogaster requires a maximum of 31 nucleotides of homologous sequence at the searching ends. 1997, Pubmed
Khurana, Adaptation to P element transposon invasion in Drosophila melanogaster. 2011, Pubmed
Kidwell, Hybrid Dysgenesis in DROSOPHILA MELANOGASTER: A Syndrome of Aberrant Traits Including Mutation, Sterility and Male Recombination. 1977, Pubmed
Kidwell, Horizontal transfer. 1992, Pubmed
Kidwell, Horizontal transfer of P elements and other short inverted repeat transposons. 1992, Pubmed
Kidwell, Cytoplasm-chromosome interactions in prosophila melanogaster. 1975, Pubmed
Kim, Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. 2013, Pubmed
Kim, Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase. 1999, Pubmed
Kimbacher, Drosophila P transposons of the urochordata Ciona intestinalis. 2009, Pubmed
Kusano, Sterility of Drosophila with mutations in the Bloom syndrome gene--complementation by Ku70. 2001, Pubmed
Labourier, Modulation of P-element pre-mRNA splicing by a direct interaction between PSI and U1 snRNP 70K protein. 2001, Pubmed
Labourier, The KH-type RNA-binding protein PSI is required for Drosophila viability, male fertility, and cellular mRNA processing. 2002, Pubmed
Lander, Initial sequencing and analysis of the human genome. 2001, Pubmed
Landree, Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination. 1999, Pubmed
Laski, Tissue specificity of Drosophila P element transposition is regulated at the level of mRNA splicing. 1986, Pubmed
Laski, Analysis of the cis-acting requirements for germ-line-specific splicing of the P-element ORF2-ORF3 intron. 1989, Pubmed
Lee, DNA binding by the KP repressor protein inhibits P-element transposase activity in vitro. 1998, Pubmed
Lee, The Drosophila P-element KP repressor protein dimerizes and interacts with multiple sites on P-element DNA. 1996, Pubmed
Lemaitre, Maternal repression of the P element promoter in the germline of Drosophila melanogaster: a model for the P cytotype. 1993, Pubmed
Liao, Insertion site preferences of the P transposable element in Drosophila melanogaster. 2000, Pubmed
Linheiro, Whole genome resequencing reveals natural target site preferences of transposable elements in Drosophila melanogaster. 2012, Pubmed
Linheiro, Testing the palindromic target site model for DNA transposon insertion using the Drosophila melanogaster P-element. 2008, Pubmed
Maggert, Methods for homologous recombination in Drosophila. 2008, Pubmed
Majumdar, The human THAP9 gene encodes an active P-element DNA transposase. 2013, Pubmed
Matunis, Characterization of the major hnRNP proteins from Drosophila melanogaster. 1992, Pubmed
Mayeda, Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. 1992, Pubmed
McVey, Multiple functions of Drosophila BLM helicase in maintenance of genome stability. 2007, Pubmed
McVey, In vivo analysis of Drosophila BLM helicase function during DNA double-strand gap repair. 2010, Pubmed
McVey, Evidence for multiple cycles of strand invasion during repair of double-strand gaps in Drosophila. 2004, Pubmed
McVey, Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion. 2004, Pubmed
McVey, MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings. 2008, Pubmed
Melek, RAG1/2-mediated resolution of transposition intermediates: two pathways and possible consequences. 2000, Pubmed
Min, A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. 1997, Pubmed
Min, Interplay between Drosophila Bloom's syndrome helicase and Ku autoantigen during nonhomologous end joining repair of P element-induced DNA breaks. 2004, Pubmed
Misra, Cytotype control of Drosophila melanogaster P element transposition: genomic position determines maternal repression. 1993, Pubmed
Misra, Cytotype control of Drosophila P element transposition: the 66 kd protein is a repressor of transposase activity. 1990, Pubmed
Montaño, The μ transpososome structure sheds light on DDE recombinase evolution. 2012, Pubmed
Mul, Reprogramming the purine nucleotide cofactor requirement of Drosophila P element transposase in vivo. 1997, Pubmed
Mullins, cis-acting DNA sequence requirements for P-element transposition. 1989, Pubmed
Niemi, Establishment and maintenance of the P cytotype associated with telomeric P elements in Drosophila melanogaster. 2004, Pubmed
Nilsen, Expansion of the eukaryotic proteome by alternative splicing. 2010, Pubmed
O'Donnell, Mighty Piwis defend the germline against genome intruders. 2007, Pubmed
O'Hare, Distribution and structure of cloned P elements from the Drosophila melanogaster P strain pi 2. 1992, Pubmed
O'Hare, Structures of P transposable elements and their sites of insertion and excision in the Drosophila melanogaster genome. 1983, Pubmed
Preston, Efficient repair of DNA breaks in Drosophila: evidence for single-strand annealing and competition with other repair pathways. 2002, Pubmed
Preston, Differential usage of alternative pathways of double-strand break repair in Drosophila. 2006, Pubmed
Reiss, aubergine mutations in Drosophila melanogaster impair P cytotype determination by telomeric P elements inserted in heterochromatin. 2004, Pubmed
Rio, Identification and immunochemical analysis of biologically active Drosophila P element transposase. 1986, Pubmed
Rio, Regulation of Drosophila P element transposition. 1991, Pubmed
Rio, Molecular mechanisms regulating Drosophila P element transposition. 1990, Pubmed
Robertson, Modified P elements that mimic the P cytotype in Drosophila melanogaster. 1989, Pubmed
Roche, P-element repressor autoregulation involves germ-line transcriptional repression and reduction of third intron splicing. 1995, Pubmed
Ronsseray, The regulatory properties of autonomous subtelomeric P elements are sensitive to a Suppressor of variegation in Drosophila melanogaster. 1996, Pubmed
Ronsseray, The maternally inherited regulation of P elements in Drosophila melanogaster can be elicited by two P copies at cytological site 1A on the X chromosome. 1991, Pubmed
Ronsseray, Telomeric transgenes and trans-silencing in Drosophila. 2003, Pubmed
Roussigne, The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. 2003, Pubmed
Sabogal, THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves. 2010, Pubmed
Savilahti, The phage Mu transpososome core: DNA requirements for assembly and function. 1995, Pubmed
Scottoline, Disruption of the terminal base pairs of retroviral DNA during integration. 1997, Pubmed
Siebel, Regulation of tissue-specific P-element pre-mRNA splicing requires the RNA-binding protein PSI. 1994, Pubmed
Siebel, The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: multiprotein complexes at an exon pseudo-5' splice site control U1 snRNP binding. 1992, Pubmed
Siebel, Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing. 1995, Pubmed
Siebel, Regulated splicing of the Drosophila P transposable element third intron in vitro: somatic repression. 1990, Pubmed
Sienski, Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression. 2012, Pubmed
Simmons, Maternal impairment of transposon regulation in Drosophila melanogaster by mutations in the genes aubergine, piwi and Suppressor of variegation 205. 2010, Pubmed
Simmons, The P cytotype in Drosophila melanogaster: a maternally transmitted regulatory state of the germ line associated with telomeric P elements. 2004, Pubmed
Simmons, Regulation of P-element transposase activity in Drosophila melanogaster by hobo transgenes that contain KP elements. 2002, Pubmed
Simmons, Cytotype regulation by telomeric P elements in Drosophila melanogaster: interactions with P elements from M' strains. 2007, Pubmed
Spradling, Transposition of cloned P elements into Drosophila germ line chromosomes. 1982, Pubmed
Spradling, Gene disruptions using P transposable elements: an integral component of the Drosophila genome project. 1995, Pubmed
Spradling, Drosophila P elements preferentially transpose to replication origins. 2011, Pubmed
Staveley, Protected P-element termini suggest a role for inverted-repeat-binding protein in transposase-induced gap repair in Drosophila melanogaster. 1995, Pubmed
Stuart, Telomeric P elements associated with cytotype regulation of the P transposon family in Drosophila melanogaster. 2002, Pubmed
Tang, Guanosine triphosphate acts as a cofactor to promote assembly of initial P-element transposase-DNA synaptic complexes. 2005, Pubmed
Tang, Analysis of P element transposase protein-DNA interactions during the early stages of transposition. 2007, Pubmed
Thorp, Cytotype regulation by telomeric P elements in Drosophila melanogaster: variation in regulatory strength and maternal effects. 2009, Pubmed
Todeschini, The epigenetic trans-silencing effect in Drosophila involves maternally-transmitted small RNAs whose production depends on the piRNA pathway and HP1. 2010, Pubmed
Tower, Preferential transposition of Drosophila P elements to nearby chromosomal sites. 1993, Pubmed
Tseng, Splicing of the Drosophila P element ORF2-ORF3 intron is inhibited in a human cell extract. 1991, Pubmed
Venken, Genome-wide manipulations of Drosophila melanogaster with transposons, Flp recombinase, and ΦC31 integrase. 2012, Pubmed
Venken, P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. 2006, Pubmed
Venken, Transgenesis upgrades for Drosophila melanogaster. 2007, Pubmed
Vos, Transposase is the only nematode protein required for in vitro transposition of Tc1. 1996, Pubmed
Witsell, Removal of the bloom syndrome DNA helicase extends the utility of imprecise transposon excision for making null mutations in Drosophila. 2009, Pubmed
Wittinghofer, The structure of Ras protein: a model for a universal molecular switch. 1991, Pubmed
Yang, Making and breaking nucleic acids: two-Mg2+-ion catalysis and substrate specificity. 2006, Pubmed
Yuan, The catalytic domain of all eukaryotic cut-and-paste transposase superfamilies. 2011, Pubmed
Zhang, Efficient and dispersed local P element transposition from Drosophila females. 1993, Pubmed
de Vanssay, Paramutation in Drosophila linked to emergence of a piRNA-producing locus. 2012, Pubmed