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As gene regulatory network models encompass more and more of the specification processes underlying sea urchin embryonic development, topological themes emerge that imply the existence of structural network ''building blocks''. These are subcircuits which perform given logic operations in the spatial control of gene expression. The various parts of the sea urchin gene regulatory networks offer instances of the same subcircuit topologies accomplishing the same developmental logic functions but using different genes. These subcircuits are dedicated to specific developmental functions, unlike simpler ''motifs'', and may indicate a repertoire of specific devices of which developmental gene regulatory networks are composed.
Amore,
Spdeadringer, a sea urchin embryo gene required separately in skeletogenic and oral ectoderm gene regulatory networks.
2003, Pubmed,
Echinobase
Amore,
Spdeadringer, a sea urchin embryo gene required separately in skeletogenic and oral ectoderm gene regulatory networks.
2003,
Pubmed
,
Echinobase
Angerer,
Sea urchin goosecoid function links fate specification along the animal-vegetal and oral-aboral embryonic axes.
2001,
Pubmed
,
Echinobase
Bolouri,
The gene regulatory network basis of the "community effect," and analysis of a sea urchin embryo example.
2010,
Pubmed
,
Echinobase
Britten,
Gene regulation for higher cells: a theory.
1969,
Pubmed
Davidson,
How embryos work: a comparative view of diverse modes of cell fate specification.
1990,
Pubmed
,
Echinobase
Davidson,
Properties of developmental gene regulatory networks.
2009,
Pubmed
,
Echinobase
Davidson,
A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo.
2002,
Pubmed
,
Echinobase
Duboc,
Nodal and BMP2/4 signaling organizes the oral-aboral axis of the sea urchin embryo.
2004,
Pubmed
,
Echinobase
Duboc,
Lefty acts as an essential modulator of Nodal activity during sea urchin oral-aboral axis formation.
2008,
Pubmed
,
Echinobase
Georgescu,
A gene regulatory network armature for T lymphocyte specification.
2009,
Pubmed
Gilchrist,
Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.
2006,
Pubmed
Huang,
Bifurcation dynamics in lineage-commitment in bipotent progenitor cells.
2007,
Pubmed
Kim,
Transcriptional regulatory circuits: predicting numbers from alphabets.
2009,
Pubmed
Koide,
Xenopus as a model system to study transcriptional regulatory networks.
2005,
Pubmed
,
Echinobase
Lee,
Control of developmental regulators by Polycomb in human embryonic stem cells.
2006,
Pubmed
Milo,
Network motifs: simple building blocks of complex networks.
2002,
Pubmed
Minokawa,
cis-Regulatory inputs of the wnt8 gene in the sea urchin endomesoderm network.
2005,
Pubmed
,
Echinobase
Nam,
Cis-regulatory control of the nodal gene, initiator of the sea urchin oral ectoderm gene network.
2007,
Pubmed
,
Echinobase
Oliveri,
Activation of pmar1 controls specification of micromeres in the sea urchin embryo.
2003,
Pubmed
,
Echinobase
Oliveri,
Global regulatory logic for specification of an embryonic cell lineage.
2008,
Pubmed
,
Echinobase
Oliveri,
Repression of mesodermal fate by foxa, a key endoderm regulator of the sea urchin embryo.
2006,
Pubmed
,
Echinobase
Oliveri,
A regulatory gene network that directs micromere specification in the sea urchin embryo.
2002,
Pubmed
,
Echinobase
Oliveri,
Development. Built to run, not fail.
2007,
Pubmed
Pan,
Nanog and transcriptional networks in embryonic stem cell pluripotency.
2007,
Pubmed
Peter,
Genomic control of patterning.
2009,
Pubmed
,
Echinobase
Peter,
The endoderm gene regulatory network in sea urchin embryos up to mid-blastula stage.
2010,
Pubmed
,
Echinobase
Range,
Cis-regulatory analysis of nodal and maternal control of dorsal-ventral axis formation by Univin, a TGF-beta related to Vg1.
2007,
Pubmed
,
Echinobase
Revilla-i-Domingo,
A missing link in the sea urchin embryo gene regulatory network: hesC and the double-negative specification of micromeres.
2007,
Pubmed
,
Echinobase
Sethi,
Gene regulatory network interactions in sea urchin endomesoderm induction.
2009,
Pubmed
,
Echinobase
Smith,
A gene regulatory network subcircuit drives a dynamic pattern of gene expression.
2007,
Pubmed
,
Echinobase
Smith,
A new method, using cis-regulatory control, for blocking embryonic gene expression.
2008,
Pubmed
,
Echinobase
Stathopoulos,
Genomic regulatory networks and animal development.
2005,
Pubmed
Su,
A perturbation model of the gene regulatory network for oral and aboral ectoderm specification in the sea urchin embryo.
2009,
Pubmed
,
Echinobase
Wei,
The sea urchin animal pole domain is a Six3-dependent neurogenic patterning center.
2009,
Pubmed
,
Echinobase
Yaguchi,
Sp-Smad2/3 mediates patterning of neurogenic ectoderm by nodal in the sea urchin embryo.
2007,
Pubmed
,
Echinobase
Yuh,
An otx cis-regulatory module: a key node in the sea urchin endomesoderm gene regulatory network.
2004,
Pubmed
,
Echinobase