Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Mar Drugs
2010 Dec 22;812:2988-98. doi: 10.3390/md8122988.
Show Gene links
Show Anatomy links
Cytotoxicity on human cancer cells of ophidiacerebrosides isolated from the African starfish Narcissia canariensis.
Farokhi F
,
Wielgosz-Collin G
,
Clement M
,
Kornprobst JM
,
Barnathan G
.
Abstract
The starfish Narcissia canariensis harvested from the coasts off Dakar, Senegal, was investigated for glycolipids (GL). This report deals with the isolation, characterization and biological activity of a fraction F13-3 separated from the GL mixture and selected according to its ability to inhibit KB cell proliferation after 72 hours of treatment. Firstly, a GL mixture F13 was obtained that accounted for 1.36% of starfish biomass (dry weight) and 0.36% of total lipids. The fraction F13-3 obtained from F13 contained three homologous GL identified as peracetylated derivatives on the basis of chemical and spectroscopic evidence. These contained a β-glucopyranoside as sugar head, a 9-methyl-branched 4,8,10-triunsaturated long-chain aminoalcohol as sphingoid base and amide-linked 2-hydroxy fatty acid chains. The majority (63%) had an amide-linked 2-hydroxydocosanoic acid chain and was identified as the ophidiacerebroside-C, firstly isolated from the starfish Ophidiaster ophidiamus. The minor components of F13-3 differed by one more or one less methylene group, and corresponded to ophidiacerebroside-B and -D. We found that F13-3 displayed an interesting cytotoxic activity over 24 hours on various adherent human cancerous cell lines (multiple myeloma, colorectal adenocarcinoma and glioblastoma multiforme) with an IC(50) of around 20 μM.
Black,
Synthesis of phalluside-1 and Sch II using 1,2-metallate rearrangements.
2010, Pubmed
Black,
Synthesis of phalluside-1 and Sch II using 1,2-metallate rearrangements.
2010,
Pubmed
Brattain,
Heterogeneity of malignant cells from a human colonic carcinoma.
1981,
Pubmed
Cartron,
Nonredundant role of Bax and Bak in Bid-mediated apoptosis.
2003,
Pubmed
Chan,
Treatment of recurrent glioblastoma multiforme with GliaSite brachytherapy.
2005,
Pubmed
Cheng,
Ceramide and cerebrosides from the octocoral Sarcophyton ehrenbergi.
2009,
Pubmed
Chludil,
Anasterocerebroside A, a new glucosylceramide from the Patagonian starfish Anasterias minuta.
2003,
Pubmed
,
Echinobase
Costantino,
Corrugoside, a new immunostimulatory alpha-galactoglycosphingolipid from the marine sponge Axinella corrugata.
2008,
Pubmed
Costantino,
Glycolipids from sponges. 13. Clarhamnoside, the first rhamnosylated alpha-galactosylceramide from Agelas clathrodes. Improving spectral strategies for glycoconjugate structure determination.
2004,
Pubmed
Decaux,
Inhibition of mTORC1 activity by REDD1 induction in myeloma cells resistant to bortezomib cytotoxicity.
2010,
Pubmed
Denizot,
Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.
1986,
Pubmed
Díaz de Vivar,
Two novel glucosylceramides from gonads and body walls of the Patagonian starfish Allostichaster inaequalis.
2002,
Pubmed
,
Echinobase
El Kihel,
New lithocholic and chenodeoxycholic piperazinylcarboxamides with antiproliferative and pro-apoptotic effects on human cancer cell lines.
2008,
Pubmed
Fattorusso,
Marine glycolipids.
1997,
Pubmed
Harousseau,
Optimising patient outcomes in myeloma.
2010,
Pubmed
Inagaki,
Isolation and structure of a galactocerebroside molecular species from the starfish Culcita novaeguineae.
2006,
Pubmed
,
Echinobase
Kawatake,
Isolation and structure determination of six glucocerebrosides from the starfish Luidia maculata.
2002,
Pubmed
,
Echinobase
Maier,
Isolation and structure of glucosylceramides from the starfish Cosmasterias lurida.
1998,
Pubmed
,
Echinobase
Mansoor,
Renierosides, cerebrosides from a marine sponge Haliclona (Reniera) sp.
2007,
Pubmed
Mitsiades,
From the bench to the bedside: emerging new treatments in multiple myeloma.
2007,
Pubmed
Namba,
Establishment of five human myeloma cell lines.
1989,
Pubmed
Towler,
A systematic review of the effects of screening for colorectal cancer using the faecal occult blood test, hemoccult.
1998,
Pubmed
