Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-45992
Biol Bull 1993 Dec 01;1853:355-364. doi: 10.2307/1542476.
Show Gene links Show Anatomy links

Multixenobiotic Resistance in Urechis caupo Embryos: Protection From Environmental Toxins.

Toomey BH , Epel D .


???displayArticle.abstract???
Urechis caupo is a marine worm that lives and reproduces in sediments containing a variety of potentially toxic environmental chemicals (xenobiotics). Its embryos have a multixenobiotic transporter, which is similar to the multidrug transporter in mammals, as indicated by their ability to transport a variety of moderately hydrophobic compounds such as dyes, drugs, and pesticides out of the cells. The cell membranes of the embryos contain a protein of approximately 145 kD that is immunologically related to the mammalian multidrug transport protein and that can be cross-linked by a photoactivatable substrate of the mammalian multidrug transport protein. The sediments in which the worm lives contain potential substrates for the transporter, indicating that this multixenobiotic transport activity may protect Urechis embryos from naturally occurring toxic compounds. Embryos of a sea urchin from a pristine environment do not have this transport activity and are sensitive to hydrophobic toxins. These data strongly support a role for multixenobiotic transport as a mechanism of protection from environmental toxins and indicate an unsuspected mode of protection in invertebrate embryos.

???displayArticle.pubmedLink??? 29300623
???displayArticle.link??? Biol Bull


Genes referenced: LOC100887844 LOC115919910