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Antibiotics (Basel) 2022 Dec 17;1112:. doi: 10.3390/antibiotics11121835.
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Genomic Analysis of Klebsiella pneumoniae ST258 Strain Coproducing KPC-2 and CTX-M-14 Isolated from Poultry in the Brazilian Amazon Region.

Valiatti TB , Cayô R , Santos FF , Bessa-Neto FO , Brandão Silva RG , Veiga R , de Nazaré Miranda Bahia M , Guerra LMGD , Pignatari ACC , de Oliveira Souza C , Brasiliense DM , Gales AC , Guarani Network .

This study aimed to characterize a Klebsiella pneumoniae strain (KP411) recovered from the stool samples of poultry (Gallus gallus) in the Brazilian Amazon Region. The whole-genome sequencing of KP411 revealed the presence of an important arsenal of antimicrobial resistance genes to β-lactams (blaCTX-M-14, blaTEM-1B, blaKPC-2, blaSVH-11), aminoglycosides [aph(3″)- Ib, aph(6)-Id, aph(3')-Ia], sulfonamides (sul1, sul2), quinolones (oqxAB), fosfomycin (fosAKP), and macrolides [mph(A)]. Furthermore, our analyses revealed that the KP411 strain belongs to the ST258 clonal lineage, which is one of the main epidemic clones responsible for the dissemination of KPC-2 worldwide. Our data suggest that food-producing animals may act as reservoirs of multidrug-resistant K. pneumoniae belonging to the ST258 clone, and, consequently, contribute to their dissemination to humans and the environment.

PubMed ID: 36551493
Article link: Antibiotics (Basel)
Grant support: [+]

References [+] :
Aires, Population Structure of KPC-2-Producing Klebsiella pneumoniae Isolated from Surveillance Rectal Swabs in Brazil. 2020, Pubmed