Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Dev Genes Evol
2005 Aug 01;2158:393-401. doi: 10.1007/s00427-005-0487-8.
Show Gene links
Show Anatomy links
Afuni, a novel transforming growth factor-beta gene is involved in arm regeneration by the brittle star Amphiura filiformis.
Bannister R
,
McGonnell IM
,
Graham A
,
Thorndyke MC
,
Beesley PW
.
???displayArticle.abstract???
The bone morphogenetic proteins (BMPs) are a family of the transforming growth factor-beta (TGF-beta) superfamily that perform multiple roles during vertebrate and invertebrate development. Here, we report the molecular cloning of a novel BMP from regenerating arms of the ophiuroid Amphiura filiformis. The theoretically translated amino acid sequence of this novel BMP has high similarity to that of the sea urchin BMP univin. This novel BMP has been named afuni. Whole-mount in situ hybridisation implicates afuni in arm regeneration. Expression occurs in distinct proximal and distal regions of late regenerates (3- and 5-week postablation). These sites are at different stages of regeneration, suggesting multiple roles for this gene in adult arm development. Cellular expression of this gene occurs in migratory cells within the radial water canal (RWC) of regenerating and nonregenerating arms. These migrating coelomocytes suggest a key role for the coelomic RWC as a source of the cellular material for use in arm regeneration by A. filiformis.
Angerer,
A BMP pathway regulates cell fate allocation along the sea urchin animal-vegetal embryonic axis.
2000, Pubmed,
Echinobase
Angerer,
A BMP pathway regulates cell fate allocation along the sea urchin animal-vegetal embryonic axis.
2000,
Pubmed
,
Echinobase
Candia Carnevali,
Microscopic overview of crinoid regeneration.
2001,
Pubmed
,
Echinobase
Chang,
Cell fate determination in embryonic ectoderm.
1998,
Pubmed
Chitnis,
Control of neurogenesis--lessons from frogs, fish and flies.
1999,
Pubmed
Combet,
NPS@: network protein sequence analysis.
2000,
Pubmed
Davidson,
Origin of bilaterian body plans: evolution of developmental regulatory mechanisms.
1995,
Pubmed
De Robertis,
A common plan for dorsoventral patterning in Bilateria.
1996,
Pubmed
Ducy,
The family of bone morphogenetic proteins.
2000,
Pubmed
Graff,
Embryonic patterning: to BMP or not to BMP, that is the question.
1997,
Pubmed
Harada,
Conserved expression pattern of BMP-2/4 in hemichordate acorn worm and echinoderm sea cucumber embryos.
2002,
Pubmed
,
Echinobase
Hogan,
Bone morphogenetic proteins: multifunctional regulators of vertebrate development.
1996,
Pubmed
Nieto,
In situ hybridization analysis of chick embryos in whole mount and tissue sections.
1996,
Pubmed
O'Kane,
Transforming growth factor beta s and wound healing.
1997,
Pubmed
Patruno,
Anbmp2/4 is a new member of the transforming growth factor-beta superfamily isolated from a crinoid and involved in regeneration.
2003,
Pubmed
Peterson,
Set-aside cells in maximal indirect development: evolutionary and developmental significance.
1997,
Pubmed
Ponce,
Molecular characterization and phylogenetic analysis of SpBMP5-7, a new member of the TGF-beta superfamily expressed in sea urchin embryos.
1999,
Pubmed
,
Echinobase
Reinhardt,
HyBMP5-8b, a BMP5-8 orthologue, acts during axial patterning and tentacle formation in hydra.
2004,
Pubmed
Saitou,
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
1987,
Pubmed
Shih,
Identification and characterization of bone morphogenetic protein 2/4 gene from the starfish Archaster typicus.
2002,
Pubmed
,
Echinobase
Stenzel,
The univin gene encodes a member of the transforming growth factor-beta superfamily with restricted expression in the sea urchin embryo.
1994,
Pubmed
,
Echinobase
Ueno,
Bone morphogenetic proteins.
1997,
Pubmed
Urist,
Bone morphogenesis in implants of insoluble bone gelatin.
1973,
Pubmed
Wozney,
Novel regulators of bone formation: molecular clones and activities.
1988,
Pubmed
Zito,
Expression of univin, a TGF-beta growth factor, requires ectoderm-ECM interaction and promotes skeletal growth in the sea urchin embryo.
2003,
Pubmed
,
Echinobase