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ECB-ART-45871
Fish Shellfish Immunol 2018 Jan 01;72:334-341. doi: 10.1016/j.fsi.2017.11.021.
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Cytotoxic activity of Holothuria tubulosa (Echinodermata) coelomocytes.

Vazzana M , Celi M , Chiaramonte M , Inguglia L , Russo D , Ferrantelli V , Battaglia D , Arizza V .


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The immune system of marine invertebrates, in particular that of holothurians, still requires further study. Our research showed that coelomocyte cells contained in the coelomic fluid of the sea cucumber, Holothuria tubulosa, are able to lyse, in vitro, red blood cells in rabbits and sheep. A plaque-forming assay showed spherule cells to be the effector cells, able to release cytotoxic molecules after xenogenic cell contact. The coelomocyte lysate supernatant, analysed by polyacrylamide gel electrophoresis overlay technique, using rabbit and sheep erythrocytes, showed two different haemolytic protein patterns: one calcium dependent and the other calcium independent. The fractions of each pattern were resolved on a polyacrylamide gel and calcium-dependent and independent coelomocyte lysate patterns were compared.

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Genes referenced: LOC100887844 LOC115919910