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Eur J Cancer
2010 Jul 01;4610:1773-80. doi: 10.1016/j.ejca.2010.04.002.
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The biology and treatment of EML4-ALK non-small cell lung cancer.
Sasaki T
,
Rodig SJ
,
Chirieac LR
,
Jänne PA
.
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The fusion between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) has recently been identified in a subset of non-small cell lung cancers (NSCLCs). EML4-ALK is most often detected in never smokers with lung cancer and has unique pathologic features. EML4-ALK is oncogenic both in vitro and in vivo and ALK kinase inhibitors are quite effective in pre-clinical model systems. More recently ALK inhibitors have entered clinical development and remarkably clinical efficacy has been observed in NSCLC patients harbouring EML4-ALK translocations. This review will focus on the biology, clinical characteristics, diagnosis and treatment of EML4-ALK NSCLC.
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20418096
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