ECB-ART-43453
Steroids
2014 Sep 01;87:119-27. doi: 10.1016/j.steroids.2014.05.027.
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Asterosaponins from the Far Eastern starfish Leptasterias ochotensis and their anticancer activity.
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Six new asterosaponins, leptasteriosides A-F (3-8), one new and one previously known asterogenins (1, 2) were isolated from the alcoholic extract of the Far Eastern starfish Leptasterias ochotensis. The structures of 1-8 were elucidated by extensive NMR and ESI-MS techniques. Compounds 2-8 showed slight or moderate cytotoxic activities against cancer cell lines RPMI-7951 and T-47D. The asterosaponins 3-5 demonstrated a significant inhibition of RPMI-7951 and T-47D cell colony formation in soft agar clonogenic assay in nontoxic doses.
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Genes referenced: LOC100893907 LOC115919910