ECB-ART-42105
Steroids
2011 Nov 01;7612:1280-7. doi: 10.1016/j.steroids.2011.06.006.
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Cariniferosides A-F and other steroidal biglycosides from the starfish Asteropsis carinifera.
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Six new steroidal biglycosides, cariniferosides A-F (1-6), were isolated along with six previously known glycosides, 7-12, from the alcoholic extract of the starfish Asteropsis carinifera. The structures of 1-6 were determined by extensive NMR and ESIMS techniques. The isolated compounds did not show any apparent cytotoxicity in cancer cell lines HCT-116, RPMI-7951, and T-47D, but sulfated compounds 6, 11, and 12 demonstrated a significant inhibition of RPMI-7951 and T-47D cell colony formation in a soft agar clonogenic assay.
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Genes referenced: LOC100893907 LOC115919910