Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Pharmaceuticals (Basel)
2022 Oct 20;1510:. doi: 10.3390/ph15101294.
Show Gene links
Show Anatomy links
Ginkgo biloba Extract Stimulates Adipogenesis in 3T3-L1 Preadipocytes.
Thomaz FM
,
de Jesus Simão J
,
da Silva VS
,
Machado MMF
,
Oyama LM
,
Ribeiro EB
,
Alonso Vale MIC
,
Telles MM
.
Abstract
Smaller adipocytes are related to the reversal of metabolic disorders, suggesting that molecules that can act in the adipogenesis pathway are of great interest. The objective of this study was to investigate the effect of Ginkgo biloba extract (GbE) in modulating the differentiation in preadipocytes. 3T3-L1 preadipocytes were differentiated for 7 days into adipocytes without (control group) and with GbE at 1.0 mg/mL. Lipid content and gene expression were analyzed on day 7 (D7) by Oil Red O staining and PCR Array Gene Expression. Western blotting analysis of the key adipogenesis markers was evaluated during the differentiation process at days 3 (D3), 5 (D5), and 7 (D7). GbE increased lipid content and raised the gene expression of the main adipogenesis markers. Key proteins of the differentiation process were modulated by GbE, since C/EBPβ levels were decreased, while C/EBPα levels were increased at D7. Regarding the mature adipocytes' markers, GbE enhanced the levels of both FABP4 at D5, and perilipin at D3 and D5. In summary, the present findings showed that GbE modulated the adipogenesis pathway suggesting that the treatment could accelerate the preadipocyte maturation, stimulating the expression of mature adipocyte proteins earlier than expected.
Ahn,
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways.
2008, Pubmed
Ahn,
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways.
2008,
Pubmed
Ali,
Adipocyte and adipogenesis.
2013,
Pubmed
Audano,
Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview.
2022,
Pubmed
Bambace,
Adiponectin gene expression and adipocyte diameter: a comparison between epicardial and subcutaneous adipose tissue in men.
2011,
Pubmed
Bu,
Bilobalide Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway.
2019,
Pubmed
Cao,
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.
1991,
Pubmed
Cefali,
Evaluation of In Vitro Solar Protection Factor (SPF), Antioxidant Activity, and Cell Viability of Mixed Vegetable Extracts from Dirmophandra mollis Benth, Ginkgo biloba L., Ruta graveolens L., and Vitis vinífera L.
2019,
Pubmed
Cho,
Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation.
2019,
Pubmed
Cruz,
Palmitoleic acid (16:1n7) increases oxygen consumption, fatty acid oxidation and ATP content in white adipocytes.
2018,
Pubmed
,
Echinobase
Curat,
From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes.
2004,
Pubmed
Dixon,
CCAAT/enhancer-binding protein alpha is required for transcription of the beta 3-adrenergic receptor gene during adipogenesis.
2001,
Pubmed
Frühbeck,
Overview of adipose tissue and its role in obesity and metabolic disorders.
2008,
Pubmed
Fu,
Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation.
2005,
Pubmed
Ghaben,
Adipogenesis and metabolic health.
2019,
Pubmed
Gustafson,
Restricted adipogenesis in hypertrophic obesity: the role of WISP2, WNT, and BMP4.
2013,
Pubmed
Halberg,
Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue.
2009,
Pubmed
Hammarstedt,
Impaired Adipogenesis and Dysfunctional Adipose Tissue in Human Hypertrophic Obesity.
2018,
Pubmed
Heinonen,
White adipose tissue mitochondrial metabolism in health and in obesity.
2020,
Pubmed
Hirata,
Ginkgo biloba extract improves insulin signaling and attenuates inflammation in retroperitoneal adipose tissue depot of obese rats.
2015,
Pubmed
,
Echinobase
Hirata,
Ginkgo biloba Extract Modulates the Retroperitoneal Fat Depot Proteome and Reduces Oxidative Stress in Diet-Induced Obese Rats.
2019,
Pubmed
,
Echinobase
Hirata,
Potential Anti-obesogenic Effects of Ginkgo biloba Observed in Epididymal White Adipose Tissue of Obese Rats.
2019,
Pubmed
,
Echinobase
Jakab,
Adipogenesis as a Potential Anti-Obesity Target: A Review of Pharmacological Treatment and Natural Products.
2021,
Pubmed
Khan,
Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI.
2009,
Pubmed
Laurencikiene,
Regulation of lipolysis in small and large fat cells of the same subject.
2011,
Pubmed
Lefterova,
New developments in adipogenesis.
2009,
Pubmed
Lefterova,
PPARγ and the global map of adipogenesis and beyond.
2014,
Pubmed
Liou,
Ginkgolide C Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway.
2015,
Pubmed
Liu,
Ginkgolic acid, a sumoylation inhibitor, promotes adipocyte commitment but suppresses adipocyte terminal differentiation of mouse bone marrow stromal cells.
2018,
Pubmed
Lundgren,
Fat cell enlargement is an independent marker of insulin resistance and 'hyperleptinaemia'.
2007,
Pubmed
Machado,
Ginkgo biloba Extract (GbE) Restores Serotonin and Leptin Receptor Levels and Plays an Antioxidative Role in the Hippocampus of Ovariectomized Rats.
2021,
Pubmed
Mahadevan,
Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses.
2008,
Pubmed
McLaughlin,
Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis.
2007,
Pubmed
Meyer,
Adipose tissue depot and cell size dependency of adiponectin synthesis and secretion in human obesity.
2013,
Pubmed
Mosmann,
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
1983,
Pubmed
Ntambi,
Adipocyte differentiation and gene expression.
2000,
Pubmed
Ohsaki,
Biogenesis of cytoplasmic lipid droplets: from the lipid ester globule in the membrane to the visible structure.
2009,
Pubmed
Richard,
CNS β3-adrenergic receptor activation regulates feeding behavior, white fat browning, and body weight.
2017,
Pubmed
Rosen,
Transcriptional regulation of adipogenesis.
2000,
Pubmed
Sethi,
Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation.
2007,
Pubmed
Skurk,
Relationship between adipocyte size and adipokine expression and secretion.
2007,
Pubmed
Trayhurn,
Endocrine and signalling role of adipose tissue: new perspectives on fat.
2005,
Pubmed
Trompezinski,
Gingko biloba extract reduces VEGF and CXCL-8/IL-8 levels in keratinocytes with cumulative effect with epigallocatechin-3-gallate.
2010,
Pubmed
Whitlock,
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies.
2009,
Pubmed
Wronska,
Structural and biochemical characteristics of various white adipose tissue depots.
2012,
Pubmed
van Heemst,
Insulin, IGF-1 and longevity.
2010,
Pubmed
