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Mem Inst Oswaldo Cruz
2019 Jan 01;114:e190079. doi: 10.1590/0074-02760190079.
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Temporal evolution of antimicrobial resistance among Neisseria gonorrhoeae clinical isolates in the most populated South American Metropolitan Region.
Martins RA
,
Cassu-Corsi D
,
Nodari CS
,
Cayô R
,
Natsumeda L
,
Streling AP
,
Doi AM
,
da Silva RJC
,
Bocalon RAL
,
Gales AC
,
Pignatari ACC
.
Abstract
A total of 124 Neisseria gonorrhoeae isolates recovered during a 12-year period (2003-2015) from outpatients assisted at Centro de Referência e Treinamento DST/AIDS-CRT of São Paulo city, Brazil, were analysed. The following resistance rates were observed: penicillin-59.6%, ciprofloxacin-15.3%, and azithromycin-6.7%. Although reduced susceptibility to these drugs was observed since 2003, no ceftriaxone-resistant isolates were detected. Ciprofloxacin- and azithromycin non-susceptible isolates were grouped in 11 clusters. Mutations were detected in GyrA and ParC of isolates 124 and 260, and a C2611T substitution on 23S rRNA alleles was also observed in isolate 260. Both isolates belonged to ST1901/ST6210 (MSLT/NG-MAST schemes).
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