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Salinity stress-induced differentially expressed miRNAs and target genes in sea cucumbers Apostichopus japonicus.
Tian Y
,
Shang Y
,
Guo R
,
Chang Y
,
Jiang Y
.
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Environmental salinity is an important abiotic factor influencing normal physiological functions and productive performance in the sea cucumber Apostichopus japonicus. It is therefore important to understand how changes in salinity affect sea cucumbers in the face of global climate change. In this study, we investigated the responses to salinity stress in sea cucumbers using mRNA and miRNA sequencing. The regulatory network of mRNAs and miRNAs involved in salinity stress was examined, and the metabolic pathways enriched for differentially expressed miRNAs and target mRNAs were identified. The top 20 pathways were involved in carbohydrate metabolism, fatty acid metabolism, degradation, and elongation, amino acid metabolism, genetic information processing, metabolism of cofactors and vitamins, transport and catabolism, and environmental information processing. A total of 22 miRNAs showed differential expression during salinity acclimation. The predicted 134 target genes were enriched in functions consistent with the results of gene enrichment based on transcriptome analysis. These results suggested that sea cucumbers deal with salinity stress via changes in amino acid metabolism, ion channels, transporters, and aquaporins, under stimulation by environmental signals, and that this process requires energy from carbohydrate and fatty acid metabolism. Salinity challenge also induced miRNA expression. These results provide a valuable genomic resource that extends our understanding of the unique biological characteristics of this economically important species under conditions of salinity stress.
Beyenbach,
The V-type H+ ATPase: molecular structure and function, physiological roles and regulation.
2006, Pubmed
Beyenbach,
The V-type H+ ATPase: molecular structure and function, physiological roles and regulation.
2006,
Pubmed
Bradbury,
Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis.
2006,
Pubmed
Breves,
Gene expression of growth hormone family and glucocorticoid receptors, osmosensors, and ion transporters in the gill during seawater acclimation of Mozambique tilapia, Oreochromis mossambicus.
2010,
Pubmed
Chaney,
Mass mortality in Pacific oysters is associated with a specific gene expression signature.
2011,
Pubmed
Chen,
Transcriptome and Molecular Pathway Analysis of the Hepatopancreas in the Pacific White Shrimp Litopenaeus vannamei under Chronic Low-Salinity Stress.
2015,
Pubmed
Chow,
Cloning and regulation of expression of the Na+-Cl--taurine transporter in gill cells of freshwater Japanese eels.
2009,
Pubmed
Corporeau,
Proteomic signatures of the oyster metabolic response to herpesvirus OsHV-1 μVar infection.
2014,
Pubmed
De Zoysa,
Transcriptional analysis of antioxidant and immune defense genes in disk abalone (Haliotis discus discus) during thermal, low-salinity and hypoxic stress.
2009,
Pubmed
Dietz,
Significance of the V-type ATPase for the adaptation to stressful growth conditions and its regulation on the molecular and biochemical level.
2001,
Pubmed
Evans,
The multifunctional fish gill: dominant site of gas exchange, osmoregulation, acid-base regulation, and excretion of nitrogenous waste.
2005,
Pubmed
Evans,
Co-ordination of osmotic stress responses through osmosensing and signal transduction events in fishes.
2010,
Pubmed
Fiess,
Effects of environmental salinity and temperature on osmoregulatory ability, organic osmolytes, and plasma hormone profiles in the Mozambique tilapia (Oreochromis mossambicus).
2007,
Pubmed
Flynt,
miR-8 microRNAs regulate the response to osmotic stress in zebrafish embryos.
2009,
Pubmed
Friedländer,
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades.
2012,
Pubmed
Godi,
FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P.
2004,
Pubmed
Greenberg,
Identifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes.
2002,
Pubmed
Hediger,
The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction.
2004,
Pubmed
Hui,
Transcriptome changes in Eriocheir sinensis megalopae after desalination provide insights into osmoregulation and stress adaption in larvae.
2014,
Pubmed
Huo,
Differential Expression of miRNAs in the Respiratory Tree of the Sea Cucumber Apostichopus japonicus Under Hypoxia Stress.
2017,
Pubmed
,
Echinobase
Ivanina,
Interactive effects of cadmium and hypoxia on metabolic responses and bacterial loads of eastern oysters Crassostrea virginica Gmelin.
2011,
Pubmed
Jeong,
Salinity changes in the anadromous river pufferfish, Takifugu obscurus, mediate gene regulation.
2014,
Pubmed
Kim,
Continuous heat shock enhances translational initiation directed by internal ribosomal entry site.
2002,
Pubmed
Koepsell,
The SLC22 family with transporters of organic cations, anions and zwitterions.
2013,
Pubmed
Langmead,
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
2009,
Pubmed
Lansdell,
RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells.
2005,
Pubmed
Li,
Transcriptome sequencing revealed the genes and pathways involved in salinity stress of Chinese mitten crab, Eriocheir sinensis.
2014,
Pubmed
Lustig,
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors.
2002,
Pubmed
Lv,
Transcriptome analysis of Portunus trituberculatus in response to salinity stress provides insights into the molecular basis of osmoregulation.
2013,
Pubmed
Lv,
The identification and characteristics of salinity-related microRNAs in gills of Portunus trituberculatus.
2016,
Pubmed
Marshall,
CFTR Cl- channel functional regulation by phosphorylation of focal adhesion kinase at tyrosine 407 in osmosensitive ion transporting mitochondria rich cells of euryhaline killifish.
2009,
Pubmed
Meng,
Genome and transcriptome analyses provide insight into the euryhaline adaptation mechanism of Crassostrea gigas.
2013,
Pubmed
Mihaljevic,
Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio).
2016,
Pubmed
Milan,
Transcriptome sequencing and microarray development for the Manila clam, Ruditapes philippinarum: genomic tools for environmental monitoring.
2011,
Pubmed
Nie,
High throughput sequencing of RNA transcriptomes in Ruditapes philippinarum identifies genes involved in osmotic stress response.
2017,
Pubmed
Parsons,
Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement.
2000,
Pubmed
Paulsen,
Structure of the TRPA1 ion channel suggests regulatory mechanisms.
2015,
Pubmed
Ranallo,
Lipid metabolism during exercise.
1998,
Pubmed
Rastorguev,
Identification of novel microRNA genes in freshwater and marine ecotypes of the three-spined stickleback (Gasterosteus aculeatus).
2016,
Pubmed
Roy,
Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake.
2017,
Pubmed
Sakamoto,
Prolactin and growth hormone in fish osmoregulation.
2006,
Pubmed
Santoni,
A proteomic study reveals novel insights into the diversity of aquaporin forms expressed in the plasma membrane of plant roots.
2003,
Pubmed
Schwer,
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2.
2006,
Pubmed
Shekhar,
Identification and expression analysis of differentially expressed genes from shrimp (Penaeus monodon) in response to low salinity stress.
2013,
Pubmed
Shi,
Characterization of the Zhikong scallop (Chlamys farreri) mantle transcriptome and identification of biomineralization-related genes.
2013,
Pubmed
Starai,
Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine.
2002,
Pubmed
Storey,
Statistical significance for genomewide studies.
2003,
Pubmed
Tipsmark,
Branchial expression patterns of claudin isoforms in Atlantic salmon during seawater acclimation and smoltification.
2008,
Pubmed
Tipsmark,
Aquaporin expression dynamics in osmoregulatory tissues of Atlantic salmon during smoltification and seawater acclimation.
2010,
Pubmed
Tournaire-Roux,
Cytosolic pH regulates root water transport during anoxic stress through gating of aquaporins.
2003,
Pubmed
Tse,
Evaluation of the anti-proliferative properties of selected psoriasis-treating Chinese medicines on cultured HaCaT cells.
2006,
Pubmed
Wang,
Effects of acute temperature or salinity stress on the immune response in sea cucumber, Apostichopus japonicus.
2008,
Pubmed
,
Echinobase
Warner,
How common are extraribosomal functions of ribosomal proteins?
2009,
Pubmed
Wen,
miREvo: an integrative microRNA evolutionary analysis platform for next-generation sequencing experiments.
2012,
Pubmed
Wiedmer,
Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3).
2004,
Pubmed
Xu,
Comparative proteome analysis of the hepatopancreas from the Pacific white shrimp Litopenaeus vannamei under long-term low salinity stress.
2017,
Pubmed
Yan,
MiR-30c: a novel regulator of salt tolerance in tilapia.
2012,
Pubmed
Yan,
miR-206 regulates the growth of the teleost tilapia (Oreochromis niloticus) through the modulation of IGF-1 gene expression.
2013,
Pubmed
Yan,
miR-429 regulation of osmotic stress transcription factor 1 (OSTF1) in tilapia during osmotic stress.
2012,
Pubmed
Yan,
Mechanism of osmoregulatory adaptation in tilapia.
2013,
Pubmed
Yang,
Elucidating the molecular mechanisms mediating plant salt-stress responses.
2018,
Pubmed
Zacchi,
Transcriptional changes in oysters Crassostrea brasiliana exposed to phenanthrene at different salinities.
2017,
Pubmed
Zhang,
In-depth profiling and analysis of host and viral microRNAs in Japanese flounder (Paralichthys olivaceus) infected with megalocytivirus reveal involvement of microRNAs in host-virus interaction in teleost fish.
2014,
Pubmed
Zhang,
The oyster genome reveals stress adaptation and complexity of shell formation.
2012,
Pubmed
Zhang,
Integrated mRNA and microRNA transcriptome analyses reveal regulation of thermal acclimation in Gymnocypris przewalskii: A case study in Tibetan Schizothoracine fish.
2017,
Pubmed
Zhang,
Differential gene expression in the intestine of sea cucumber (Apostichopus japonicus) under low and high salinity conditions.
2018,
Pubmed
,
Echinobase
Zhang,
Proteomic basis of stress responses in the gills of the pacific oyster Crassostrea gigas.
2015,
Pubmed
Zhang,
Transcriptome analysis reveals a rich gene set related to innate immunity in the Eastern oyster (Crassostrea virginica).
2014,
Pubmed
Zhao,
High throughput sequencing of small RNAs transcriptomes in two Crassostrea oysters identifies microRNAs involved in osmotic stress response.
2016,
Pubmed
Zhao,
Transcriptomic responses to salinity stress in the Pacific oyster Crassostrea gigas.
2012,
Pubmed
Zhou,
Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status.
2010,
Pubmed
