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ECB-ART-42111
Chem Commun (Camb) 2011 Sep 14;4734:9726-8. doi: 10.1039/c1cc13200h.
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Synthesis of the glycan moiety of ganglioside HPG-7 with an unusual trimer of sialic acid as the inner sugar residue.

Iwayama Y , Ando H , Tanaka HN , Ishida H , Kiso M .


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The glycan moiety of ganglioside HPG-7, isolated from the sea cucumber (Holothuria pervicax), was synthesized for the first time. The characteristic substructure, a trisialic acid sequence embedded in the glycan, was deliberately constructed by utilizing suitably differentiated sialyl units for various synthetic purposes. Finally, a pentasaccharide was successfully delivered as the hexyl glycoside.

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Genes referenced: LOC100887844