ECB-ART-31901
EMBO J
1989 Aug 01;88:2275-82. doi: 10.1002/j.1460-2075.1989.tb08353.x.
Show Gene links
Show Anatomy links
Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase.
Meijer L
,
Arion D
,
Golsteyn R
,
Pines J
,
Brizuela L
,
Hunt T
,
Beach D
.
???displayArticle.abstract???
A so-called ''growth-associated'' or ''M-phase specific'' histone H1 kinase (H1K) has been described in a wide variety of eukaryotic cell types; p34cdc2 has previously been shown to be a
catalytic subunit of this
protein kinase . In fertilized sea urchin eggs the activity of H1K oscillates during the cell division cycle and there is a striking temporal correlation between H1K activation and the accumulation of a phosphorylated form of cyclin. H1K activity declines in parallel with proteolytic cyclin destruction of the end of the first cell cycle. By virtue of the high affinity of the fission yeast p13suc1 for the p34cdc2 protein, H1K strongly binds to p13-Sepharose beads. Cyclin, p34cdc2 and H1K co-purify on this affinity reagent as well as through several conventional chromatographic procedures. Anticyclin antibodies immunoprecipitate the M-phase specific H1K in crude extracts or in purified fractions. Sea urchin eggs appear to contain much less cyclin than p34cdc2, suggesting that p34cdc2 may interact with other proteins. These results demonstrate that cyclin and p34cdc2 are major components of the M-phase specific H1K.
???displayArticle.pubmedLink???
2551679
???displayArticle.pmcLink???
PMC401159
???displayArticle.link???
EMBO J
???displayArticle.grants???
[+]
Genes referenced:
LOC100887844
LOC115919910
LOC586799
ppp2cb
???displayArticle.antibodies???
ccnb2 Ab1
References [+] :
,
Cyclin in fission yeast.
1988,
Pubmed
,
Cyclin in fission yeast.
1988,
Pubmed
Arion,
cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF.
1988,
Pubmed
,
Echinobase
Booher,
Interaction between cdc13+ and cdc2+ in the control of mitosis in fission yeast; dissociation of the G1 and G2 roles of the cdc2+ protein kinase.
1987,
Pubmed
Booher,
Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules.
1988,
Pubmed
Bradbury,
Control of cell division by very lysine rich histone (F1) phosphorylation.
1974,
Pubmed
Brizuela,
p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase.
1987,
Pubmed
Cicirelli,
Activation of multiple protein kinases during the burst in protein phosphorylation that precedes the first meiotic cell division in Xenopus oocytes.
1988,
Pubmed
Draetta,
Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement.
1988,
Pubmed
Draetta,
Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate.
1989,
Pubmed
Draetta,
Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF.
1989,
Pubmed
,
Echinobase
Draetta,
Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+.
1987,
Pubmed
Dunphy,
The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis.
1988,
Pubmed
Evans,
Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division.
1983,
Pubmed
,
Echinobase
Gautier,
Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+.
1988,
Pubmed
Hardie,
Cell-cycle dependence of two nuclear histone kinase enzyme activities.
1976,
Pubmed
Hohmann,
Phosphorylation of H1 histones.
1983,
Pubmed
Labbe,
Activation at M-phase of a protein kinase encoded by a starfish homologue of the cell cycle control gene cdc2+.
1988,
Pubmed
,
Echinobase
Labbé,
An M-phase-specific protein kinase of Xenopus oocytes: partial purification and possible mechanism of its periodic activation.
1988,
Pubmed
Laemmli,
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
1970,
Pubmed
Lake,
Occurrence and properties of a chromatin-associated F1-histone phosphokinase in mitotic Chinese hamster cells.
1972,
Pubmed
Lee,
Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2.
1987,
Pubmed
Lohka,
Purification of maturation-promoting factor, an intracellular regulator of early mitotic events.
1988,
Pubmed
Matthews,
Nuclear protein kinases.
1984,
Pubmed
Meijer,
Cyclic activation of histone H1 kinase during sea urchin egg mitotic divisions.
1988,
Pubmed
,
Echinobase
Meijer,
Differential regulation of histone H1 and ribosomal S6 kinases during sea star oocyte maturation.
1987,
Pubmed
,
Echinobase
Minshull,
Translation of cyclin mRNA is necessary for extracts of activated xenopus eggs to enter mitosis.
1989,
Pubmed
Murray,
Cyclin synthesis drives the early embryonic cell cycle.
1989,
Pubmed
Murray,
The role of cyclin synthesis and degradation in the control of maturation promoting factor activity.
1989,
Pubmed
Pelech,
Characterization of maturation-activated histone H1 and ribosomal S6 kinases in sea star oocytes.
1987,
Pubmed
,
Echinobase
Pines,
Molecular cloning and characterization of the mRNA for cyclin from sea urchin eggs.
1987,
Pubmed
,
Echinobase
Quirin-Stricker,
Purification and characterization of a specific histone H1 protein kinase from mouse plasmacytoma.
1981,
Pubmed
Quirin-Stricker,
Histone H1 kinase from mouse plasmacytoma. Further characterization and molecular structure.
1984,
Pubmed
Reed,
Protein kinase activity associated with the product of the yeast cell division cycle gene CDC28.
1985,
Pubmed
Rosenthal,
Selective translation of mRNA controls the pattern of protein synthesis during early development of the surf clam, Spisula solidissima.
1980,
Pubmed
Schlepper,
Nuclear protein kinases from murine cells.
1975,
Pubmed
Scott,
Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase.
1986,
Pubmed
Simanis,
The cell cycle control gene cdc2+ of fission yeast encodes a protein kinase potentially regulated by phosphorylation.
1986,
Pubmed
Standart,
Cyclin synthesis, modification and destruction during meiotic maturation of the starfish oocyte.
1987,
Pubmed
,
Echinobase
Swenson,
The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes.
1986,
Pubmed
Tabor,
A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.
1985,
Pubmed
Westendorf,
The role of cyclin B in meiosis I.
1989,
Pubmed
Woodford,
Histone H1 kinase in exponential and synchronous populations of Chinese hamster fibroblasts.
1986,
Pubmed
Wu,
Histones and their modifications.
1986,
Pubmed
Zeilig,
Studies on the mechanism of activation of mitotic histone H1 kinase.
1980,
Pubmed