Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-30652
Cell 1977 Jul 01;113:651-61. doi: 10.1016/0092-8674(77)90082-4.
Show Gene links Show Anatomy links

Presence of histone mRNA sequences in high molecular weight RNA of HeLa cells.

Melli M , Spinelli G , Wyssling H , Arnold E .


???displayArticle.abstract???
Pulse-labeled HeLa cell RNA centrifuged under denaturing conditions was hybridized with DNA of recombinant phages containing sea urchin histone genes. This cross-hybridization showed the presence of histone mRNA sequences in high molecular weight RNA molecules. Treatment of the cells with actinomycin to stop RNA synthesis resulted in the rapid decay of this high molecular weight RNA followed by an increase of 9S histone mRNA in the cytoplasm. The results are consistent with the presence in HeLa cells of a high molecular weight precursor to histone messengers.

???displayArticle.pubmedLink??? 884739
???displayArticle.link??? Cell


Genes referenced: LOC100887844 LOC115919910