Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-36150
FEBS Lett 1993 Aug 23;3291-2:210-4. doi: 10.1016/0014-5793(93)80223-h.
Show Gene links Show Anatomy links

Ionic bases of the membrane potential and intracellular pH changes induced by speract in swollen sea urchin sperm.

Reynaud E , De de La Torre L , Zapata O , Liévano A , Darszon A .


???displayArticle.abstract???
Signal transduction initiated by the egg peptide, speract, in sea urchin sperm is not fully understood. Hypotonically swollen sperm are a suitable model to study peptide signal transduction. Ion substitution experiments now indicate (i) that the permeability to Na+, Ca2+, and Mg2+ contributes to the sperm resting membrane potential; (ii) the repolarization induced by nM concentrations of speract is Na+ dependent and mediated by an as yet unidentified channel; (iii) the depolarization triggered by nM concentrations of speract involves Ca2+ channels since it is Ca(2+)-dependent and blocked by Co2+ and Ni2+, two Ca2+ channel blockers; (iv) hyperpolarizing swollen sperm with valinomycin increases intracellular pH (pHi) in the same way as speract, thus the speract-induced hyperpolarization may be responsible for the pHi increase.

???displayArticle.pubmedLink??? 8354397
???displayArticle.link??? FEBS Lett


Genes referenced: LOC100887844 LOC576642