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Proc Natl Acad Sci U S A
1993 Jul 15;9014:6854-8. doi: 10.1073/pnas.90.14.6854.
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Sea urchin early histone H2A modulator binding factor 1 is a positive transcription factor also for the early histone H3 gene.
Palla F
,
Bonura C
,
Anello L
,
Casano C
,
Ciaccio M
,
Spinelli G
.
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To shed some light on the mechanisms involved in the coordinate regulation of the early histone gene set during sea urchin development, we tested the hypothesis that the upstream sequence element USE1, previously identified in the early H2A modulator, could also participate in the transcription of the early histone H3 gene. We found by DNAse I protection analysis and by competition in electrophoretic mobility-shift experiments that two sequence elements of the H3 promoter closely resembled the USE1-H2A sequence in their binding activity for nuclear factors from 64-cell stage embryos. These modulator binding factor 1 (MBF-1)-related factors seem to recognize the ACAGA motif that is conserved between the USE1-like sequences of both H2A and H3 promoters. In fact, excess oligonucleotide containing a mutated USE1-H2A element in which the ACAGA sequence was mutated to AGTCA failed to compete with the USE1 sites of both H2A and H3 genes for interaction with MBF-1. Finally, in vivo transcriptional analysis in both Xenopus and sea urchin showed that an excess of USE1-H2A element efficiently competed for the activity of the H3 promoter. From these results we conclude that MBF-1 is a transcription factor conserved between sea urchin and frog and that MBF-1 or related transcription factors are involved in the coordinate expression of both H2A and H3 early histone genes.
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,
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Barberis,
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,
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Barberis,
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,
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Bryan,
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,
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Childs,
Histone gene expression during sea urchin embryogenesis: isolation and characterization of early and late messenger RNAs of Strongylocentrotus purpuratus by gene-specific hybridization and template activity.
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,
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DiLiberto,
Developmental control of promoter-specific factors responsible for the embryonic activation and inactivation of the sea urchin early histone H3 gene.
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,
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Grosschedl,
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,
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,
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Grosschedl,
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,
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Hentschel,
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Hieter,
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,
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Lai,
Characterization of the structure and transcriptional patterns of the gene encoding the late histone subtype H1-beta of the sea urchin Strongylocentrotus purpuratus.
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,
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Lai,
An embryonic enhancer determines the temporal activation of a sea urchin late H1 gene.
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,
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Lee,
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,
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Luckow,
CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements.
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Marzluff,
Multiple regulatory steps control histone mRNA concentrations.
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McMahon,
Introduction of cloned DNA into sea urchin egg cytoplasm: replication and persistence during embryogenesis.
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,
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Osley,
Identification of sequences in a yeast histone promoter involved in periodic transcription.
1986,
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Palla,
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,
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Roberts,
Nucleotide sequences of Caenorhabditis elegans core histone genes. Genes for different histone classes share common flanking sequence elements.
1989,
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Schümperli,
Multilevel regulation of replication-dependent histone genes.
1988,
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Spinelli,
Evidences of two different sets of histone genes active during embryogenesis of the sea urchin Paracentrotus lividus.
1979,
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,
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Spinelli,
Chromatin structure of histone genes in sea urchin sperms and embryos.
1982,
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,
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Spinelli,
Functional activity and chromatin configuration of SV40 enhancer injected in Xenopus laevis oocytes.
1985,
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Tung,
Positive and negative transcriptional regulatory elements in the early H4 histone gene of the sea urchin, Strongylocentrotus purpuratus.
1990,
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,
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Tung,
Sea urchin early and late H4 histone genes bind a specific transcription factor in a stable preinitiation complex.
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,
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Vitelli,
Developmental regulation of micro-injected histone genes in sea urchin embryos.
1988,
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,
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Weinberg,
Timing and rates of synthesis of early histone mRNA in the embryo of Strongylocentrotus purpuratus.
1983,
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,
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Zhao,
Activation of a late H2B histone gene in blastula-stage sea urchin embryos by an unusual enhancer element located 3' of the gene.
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,
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Zhao,
Activation of the L1 late H2B histone gene in blastula-stage sea urchin embryos by Antennapedia-class homeoprotein.
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Pubmed
,
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van Wijnen,
Human H4 histone gene transcription requires the proliferation-specific nuclear factor HiNF-D. Auxiliary roles for HiNF-C (Sp1-like) and HiNF-A (high mobility group-like).
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van Wijnen,
Coordination of protein-DNA interactions in the promoters of human H4, H3, and H1 histone genes during the cell cycle, tumorigenesis, and development.
1991,
Pubmed
van Wijnen,
Protein/DNA interactions involving ATF/AP1-, CCAAT-, and HiNF-D-related factors in the human H3-ST519 histone promoter: cross-competition with transcription regulatory sites in cell cycle controlled H4 and H1 histone genes.
1991,
Pubmed
