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ECB-ART-41290
Proc Natl Acad Sci U S A 2009 Oct 27;10643:18291-6. doi: 10.1073/pnas.0910007106.
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Regulative recovery in the sea urchin embryo and the stabilizing role of fail-safe gene network wiring.

Smith J , Davidson EH .


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Design features that ensure reproducible and invariant embryonic processes are major characteristics of current gene regulatory network models. New cis-regulatory studies on a gene regulatory network subcircuit activated early in the development of the sea urchin embryo reveal a sequence of encoded "fail-safe" regulatory devices. These ensure the maintenance of fate separation between skeletogenic and nonskeletogenic mesoderm lineages. An unexpected consequence of the network design revealed in the course of these experiments is that it enables the embryo to "recover" from regulatory interference that has catastrophic effects if this feature is disarmed. A reengineered regulatory system inserted into the embryo was used to prove how this system operates in vivo. Genomically encoded backup control circuitry thus provides the mechanism underlying a specific example of the regulative development for which the sea urchin embryo has long been famous.

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Genes referenced: LOC100887844

References [+] :
Andrioli, Groucho-dependent repression by sloppy-paired 1 differentially positions anterior pair-rule stripes in the Drosophila embryo. 2004, Pubmed