ECB-ART-31583
Science
1990 Jan 19;2474940:327-9. doi: 10.1126/science.2153316.
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Microinjection of a conserved peptide sequence of p34cdc2 induces a Ca2+ transient in oocytes.
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The product of the yeast cell cycle control gene cdc2, and its homologs in higher eukaryotes (p34cdc2), all contain a perfectly conserved sequence of 16 amino acids that has not been found in any other protein sequence. Microinjection of this peptide triggers a specific increase in the concentration of intracellular free Ca2+ that originates from intracellular stores in both starfish and Xenopus oocytes. Thus, p34cdc2 might interact through its conserved peptide domain with some component of the Ca2(+)-regulatory system.
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Genes referenced: LOC115919910