Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Dev Genes Evol
2008 Dec 01;21811-12:667-80. doi: 10.1007/s00427-008-0255-7.
Show Gene links
Show Anatomy links
The amphioxus genome enlightens the evolution of the thyroid hormone signaling pathway.
Paris M
,
Brunet F
,
Markov GV
,
Schubert M
,
Laudet V
.
???displayArticle.abstract???
Thyroid hormones (THs) have pleiotropic effects on vertebrate development, with amphibian metamorphosis as the most spectacular example. However, developmental functions of THs in non-vertebrate chordates are largely hypothetical and even TH endogenous production has been poorly investigated. In order to get better insight into the evolution of the thyroid hormone signaling pathway in chordates, we have taken advantage of the recent release of the amphioxus genome. We found amphioxus homologous sequences to most of the genes encoding proteins involved in thyroid hormone signaling in vertebrates, except the fast-evolving thyroglobulin: sodium iodide symporter, thyroid peroxidase, deiodinases, thyroid hormone receptor, TBG, and CTHBP. As only some genes encoding proteins involved in TH synthesis regulation were retrieved (TRH, TSH receptor, and CRH receptor but not their corresponding receptors and ligands), there may be another mode of upstream regulation of TH synthesis in amphioxus. In accord with the notion that two whole genome duplications took place at the base of the vertebrate tree, one amphioxus gene often corresponded to several vertebrate homologs. However, some amphioxus specific duplications occurred, suggesting that several steps of the TH pathway were independently elaborated in the cephalochordate and vertebrate lineages. The present results therefore indicate that amphioxus is capable of producing THs. As several genes of the TH signaling pathway were also found in the sea urchin genome, we propose that the thyroid hormone signaling pathway is of ancestral origin in chordates, if not in deuterostomes, with specific elaborations in each lineage, including amphioxus.
Baqui,
Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes.
2003, Pubmed
Baqui,
Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes.
2003,
Pubmed
Berry,
Type I iodothyronine deiodinase is a selenocysteine-containing enzyme.
1991,
Pubmed
Bianco,
Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.
2002,
Pubmed
Boorse,
Acceleration of Ambystoma tigrinum metamorphosis by corticotropin-releasing hormone.
2002,
Pubmed
COVELLI,
[On the formation of thyroid hormones and of their precursors by Branchiostoma lanceolatum Pallas (Amphioxus)].
1960,
Pubmed
Callery,
Frogs without polliwogs: evolution of anuran direct development.
2001,
Pubmed
Castresana,
Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis.
2000,
Pubmed
Curcio,
The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line.
2001,
Pubmed
Daiyasu,
Molecular evolution of the myeloperoxidase family.
2000,
Pubmed
Dehal,
Two rounds of whole genome duplication in the ancestral vertebrate.
2005,
Pubmed
Denver,
Environmental stress as a developmental cue: corticotropin-releasing hormone is a proximate mediator of adaptive phenotypic plasticity in amphibian metamorphosis.
1997,
Pubmed
Dohán,
The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance.
2003,
Pubmed
Eales,
Iodine metabolism and thyroid-related functions in organisms lacking thyroid follicles: are thyroid hormones also vitamins?
1997,
Pubmed
,
Echinobase
Edgar,
MUSCLE: multiple sequence alignment with high accuracy and high throughput.
2004,
Pubmed
Escriva,
Analysis of lamprey and hagfish genes reveals a complex history of gene duplications during early vertebrate evolution.
2002,
Pubmed
Flamant,
International Union of Pharmacology. LIX. The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors.
2006,
Pubmed
Flamant,
Thyroid hormone receptors: lessons from knockout and knock-in mutant mice.
2003,
Pubmed
Force,
Preservation of duplicate genes by complementary, degenerative mutations.
1999,
Pubmed
Galtier,
SEAVIEW and PHYLO_WIN: two graphic tools for sequence alignment and molecular phylogeny.
1996,
Pubmed
Gopal,
Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney.
2007,
Pubmed
Guindon,
A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.
2003,
Pubmed
Heyland,
Heterochronic developmental shift caused by thyroid hormone in larval sand dollars and its implications for phenotypic plasticity and the evolution of nonfeeding development.
2004,
Pubmed
,
Echinobase
Heyland,
Endogenous thyroid hormone synthesis in facultative planktotrophic larvae of the sand dollar Clypeaster rosaceus: implications for the evolutionary loss of larval feeding.
2006,
Pubmed
,
Echinobase
Hodin,
Expanding networks: Signaling components in and a hypothesis for the evolution of metamorphosis.
2006,
Pubmed
,
Echinobase
Holland,
The amphioxus genome illuminates vertebrate origins and cephalochordate biology.
2008,
Pubmed
Howard-Ashby,
Gene families encoding transcription factors expressed in early development of Strongylocentrotus purpuratus.
2006,
Pubmed
,
Echinobase
Hulbert,
Thyroid hormones and their effects: a new perspective.
2000,
Pubmed
Kryukov,
Characterization of mammalian selenoproteomes.
2003,
Pubmed
Lynch,
The evolutionary fate and consequences of duplicate genes.
2000,
Pubmed
Manzon,
Molecular cloning, tissue distribution, and developmental expression of lamprey transthyretins.
2007,
Pubmed
Manzon,
Variable effects of goitrogens in inducing precocious metamorphosis in sea lampreys (Petromyzon marinus).
2001,
Pubmed
Markov,
The evolution of the ligand/receptor couple: a long road from comparative endocrinology to comparative genomics.
2008,
Pubmed
Marlétaz,
Chaetognath transcriptome reveals ancestral and unique features among bilaterians.
2008,
Pubmed
Novinec,
Diversity and evolution of the thyroglobulin type-1 domain superfamily.
2006,
Pubmed
Ogasawara,
Overlapping expression of amphioxus homologs of the thyroid transcription factor-1 gene and thyroid peroxidase gene in the endostyle: insight into evolution of the thyroid gland.
2000,
Pubmed
Ogasawara,
Ascidian homologs of mammalian thyroid peroxidase genes are expressed in the thyroid-equivalent region of the endostyle.
1999,
Pubmed
,
Echinobase
Paris,
The history of a developmental stage: metamorphosis in chordates.
2008,
Pubmed
Paris,
Amphioxus postembryonic development reveals the homology of chordate metamorphosis.
2008,
Pubmed
Patricolo,
Presence of thyroid hormones in ascidian larvae and their involvement in metamorphosis.
2001,
Pubmed
Power,
Thyroid hormones in growth and development of fish.
2001,
Pubmed
Putnam,
The amphioxus genome and the evolution of the chordate karyotype.
2008,
Pubmed
Robinson,
Sensitivity of the relative-rate test to taxonomic sampling.
1998,
Pubmed
Rodriguez,
Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes.
2002,
Pubmed
Safi,
The axolotl (Ambystoma mexicanum), a neotenic amphibian, expresses functional thyroid hormone receptors.
2004,
Pubmed
Schreiber,
The evolution of gene expression, structure and function of transthyretin.
1997,
Pubmed
Schubert,
Nuclear hormone receptor signaling in amphioxus.
2008,
Pubmed
Shepherdley,
An ascidian homolog of vertebrate iodothyronine deiodinases.
2004,
Pubmed
Tata,
Amphibian metamorphosis as a model for the developmental actions of thyroid hormone.
2006,
Pubmed
Vandenborne,
Cloning and hypothalamic distribution of the chicken thyrotropin-releasing hormone precursor cDNA.
2005,
Pubmed
Wu,
Alternate pathways of thyroid hormone metabolism.
2005,
Pubmed
Yen,
Physiological and molecular basis of thyroid hormone action.
2001,
Pubmed
