ECB-ART-41458
Chem Biodivers
2010 Jan 01;71:158-67. doi: 10.1002/cbdv.200800324.
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Two new cytotoxic disulfated holostane glycosides from the sea cucumber Pentacta quadrangularis.
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Two new disulfated triterpene glycosides, pentactasides B and C (1 and 2, resp.), were isolated from the sea cucumber Pentacta quadrangularis collected from the South China Sea. Their structures were elucidated by extensive spectral analysis (2D-NMR and MS) and chemical methods. The compounds 1 and 2 possess the same tetrasaccharide moieties with two sulfated groups, but are different in the side chains of the triterpene aglycone. Pentactasides B and C (1 and 2, resp.) showed significant cytotoxicities (IC(50) 0.09-2.30 microM) against different human tumor cell lines.
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Genes referenced: LOC100887844 LOC100893907 LOC115919910