Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-37245
Mol Biol Cell 1999 Aug 01;108:2735-43. doi: 10.1091/mbc.10.8.2735.
Show Gene links Show Anatomy links

Syntaxin is required for cell division.

Conner SD , Wessel GM .


???displayArticle.abstract???
We recently identified a single family member homologue of syntaxin in the sea urchin. Syntaxin is present throughout development, and in rapidly dividing cleavage stage embryos it is present on numerous vesicles at the cell cortex. We hypothesized that syntaxin mediates essential membrane fusion events during early embryogenesis, reasoning that the vesicles and/or their contents are important for development. Here we show that functional inactivation of syntaxin with either Botulinum neurotoxin C1, which specifically proteolyzes syntaxin, or antibodies against syntaxin results in an inhibition of cell division. These observations suggest that syntaxin is essential for membrane fusion events critical for cell division.

???displayArticle.pubmedLink??? 10436024
???displayArticle.pmcLink??? PMC25508
???displayArticle.link??? Mol Biol Cell


Genes referenced: LOC100887844 LOC115919910
???displayArticle.antibodies??? LOC373476 Ab1

References [+] :
Bennett, The syntaxin family of vesicular transport receptors. 1993, Pubmed