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Echinobase
ECB-ART-43409
Mar Drugs 2014 May 13;125:2922-36. doi: 10.3390/md12052922.
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Echinochrome A protects mitochondrial function in cardiomyocytes against cardiotoxic drugs.

Jeong SH , Kim HK , Song IS , Lee SJ , Ko KS , Rhee BD , Kim N , Mishchenko NP , Fedoryev SA , Stonik VA , Han J .


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Echinochrome A (Ech A) is a naphthoquinoid pigment from sea urchins that possesses antioxidant, antimicrobial, anti-inflammatory and chelating abilities. Although Ech A is the active substance in the ophthalmic and cardiac drug Histochrome®, its underlying cardioprotective mechanisms are not well understood. In this study, we investigated the protective role of Ech A against toxic agents that induce death of rat cardiac myoblast H9c2 cells and isolated rat cardiomyocytes. We found that the cardiotoxic agents tert-Butyl hydroperoxide (tBHP, organic reactive oxygen species (ROS) inducer), sodium nitroprusside (SNP; anti-hypertension drug), and doxorubicin (anti-cancer drug) caused mitochondrial dysfunction such as increased ROS level and decreased mitochondrial membrane potential. Co-treatment with Ech A, however, prevented this decrease in membrane potential and increase in ROS level. Co-treatment of Ech A also reduced the effects of these cardiotoxic agents on mitochondrial oxidative phosphorylation and adenosine triphosphate level. These findings indicate the therapeutic potential of Ech A for reducing cardiotoxic agent-induced damage.

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Species referenced: Echinodermata
Genes referenced: LOC100887844 LOC115919910 mapk1 mapk9 ros1 tert


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References [+] :
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