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Proc Natl Acad Sci U S A 2014 Dec 02;11148:17278-83. doi: 10.1073/pnas.1416625111.
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Densovirus associated with sea-star wasting disease and mass mortality.

Hewson I , Button JB , Gudenkauf BM , Miner B , Newton AL , Gaydos JK , Wynne J , Groves CL , Hendler G , Murray M , Fradkin S , Breitbart M , Fahsbender E , Lafferty KD , Kilpatrick AM , Miner CM , Raimondi P , Lahner L , Friedman CS , Daniels S , Haulena M , Marliave J , Burge CA , Eisenlord ME , Harvell CD .

Populations of at least 20 asteroid species on the Northeast Pacific Coast have recently experienced an extensive outbreak of sea-star (asteroid) wasting disease (SSWD). The disease leads to behavioral changes, lesions, loss of turgor, limb autotomy, and death characterized by rapid degradation ("melting"). Here, we present evidence from experimental challenge studies and field observations that link the mass mortalities to a densovirus (Parvoviridae). Virus-sized material (i.e., <0.2 μm) from symptomatic tissues that was inoculated into asymptomatic asteroids consistently resulted in SSWD signs whereas animals receiving heat-killed (i.e., control) virus-sized inoculum remained asymptomatic. Viral metagenomic investigations revealed the sea star-associated densovirus (SSaDV) as the most likely candidate virus associated with tissues from symptomatic asteroids. Quantification of SSaDV during transmission trials indicated that progression of SSWD paralleled increased SSaDV load. In field surveys, SSaDV loads were more abundant in symptomatic than in asymptomatic asteroids. SSaDV could be detected in plankton, sediments and in nonasteroid echinoderms, providing a possible mechanism for viral spread. SSaDV was detected in museum specimens of asteroids from 1942, suggesting that it has been present on the North American Pacific Coast for at least 72 y. SSaDV is therefore the most promising candidate disease agent responsible for asteroid mass mortality.

PubMed ID: 25404293
PMC ID: PMC4260605
Article link: Proc Natl Acad Sci U S A

Genes referenced: LOC100887844

References [+] :
Bates, Effects of temperature, season and locality on wasting disease in the keystone predatory sea star Pisaster ochraceus. 2010, Pubmed, Echinobase