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Nanomaterials (Basel)
2021 Feb 10;112:. doi: 10.3390/nano11020451.
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Structural, Optical and Antibacterial Efficacy of Pure and Zinc-Doped Copper Oxide against Pathogenic Bacteria.
Khalid A
,
Ahmad P
,
Alharthi AI
,
Muhammad S
,
Khandaker MU
,
Rehman M
,
Faruque MRI
,
Din IU
,
Alotaibi MA
,
Alzimami K
,
Bradley DA
.
Abstract
Copper oxide and Zinc (Zn)-doped Copper oxide nanostructures (CuO-NSs) are successfully synthesized by using a hydrothermal technique. The as-obtained pure and Zn-doped CuO-NSs were tested to study the effect of doping in CuO on structural, optical, and antibacterial properties. The band gap of the nanostructures is calculated by using the Tauc plot. Our results have shown that the band gap of CuO reduces with the addition of Zinc. Optimization of processing conditions and concentration of precursors leads to the formation of pine needles and sea urchin-like nanostructures. The antibacterial properties of obtained Zn-doped CuO-NSs are observed against Gram-negative (Pseudomonas aeruginosa, Klebsiella pneumonia, Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria via the agar well diffusion method. Zn doped s are found to have more effective bacterial resistance than pure CuO. The improved antibacterial activity is attributed to the reactive oxygen species (ROS) generation.
Figure 1. FE-SEM micrographs of the (a,b) pure copper oxide and (c,d) shows the micrographs of Zinc (Zn)-doped Copper oxide (Zn-doped CuO).
Figure 2. XRD pattern of Zn-doped CuO nanoparticles showing peaks for different content in the sample.
Figure 3. Williamson-Hall (W-H) analysis for (a) CuO and (b) Zn-doped CuO nanostructures.
Figure 4. Analysis of microstructural parameters, such as crystallite size D and micro-strain (ε), with respect to Zinc concentration for the synthesized samples.
Figure 5. (a) X-ray photoelectron spectroscopy (XPS) survey of the as-synthesized Zn-doped CuO nanostructures. (b) High resolution Zn 2p, (c) Cu 2p, and (d) O 1s XPS spectra.
Figure 6. UV-visible absorption spectra of pure and Zinc (Zn)-doped copper oxide nanostructures (Zn-doped CuO-NSs).
Figure 7. Band gap absorption edges of CuO and Zn-doped CuO nanostructures.
Figure 8. Zone of inhibition formed by CuO-NSs against different bacteria.
Figure 9. Zone of inhibition formed by Zn-doped CuO-NSs against different bacteria.
Figure 10. Bar graph showing the diameter of the zone of inhibition (in mm) produced by (a) pure and (b) Zn-doped CuO nanoparticles (NPs) against gram-positive and gram-negative bac-tria.
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