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Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition. , Okumura E, Fukuhara T, Yoshida H, Hanada Si S, Kozutsumi R, Mori M, Tachibana K, Kishimoto T ., Nat Cell Biol. February 1, 2002; 4 (2): 111-6.
PDK1 is required for the hormonal signaling pathway leading to meiotic resumption in starfish oocytes. , Hiraoka D, Hori-Oshima S, Fukuhara T, Tachibana K, Okumura E, Kishimoto T ., Dev Biol. December 15, 2004; 276 (2): 330-6.
PE, a new sulfated saponin from sea cucumber, exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo. , Tian F, Zhang X, Tong Y, Yi Y , Zhang S, Li L , Sun P, Lin L, Ding J., Cancer Biol Ther. August 1, 2005; 4 (8): 874-82.
PKB/ AKT is involved in resumption of meiosis in mouse oocytes. , Kalous J, Solc P, Baran V, Kubelka M, Schultz RM, Motlik J., Biol Cell. February 1, 2006; 98 (2): 111-23.
Hormone-induced cortical maturation ensures the slow block to polyspermy and does not couple with meiotic maturation in starfish. , Hirohashi N, Harada K, Chiba K., Dev Biol. June 1, 2008; 318 (1): 194-202.
A primer on meiotic resumption in starfish oocytes: the proposed signaling pathway triggered by maturation-inducing hormone. , Kishimoto T ., Mol Reprod Dev. January 1, 2011; 78 (10-11): 704-7.
A polysaccharide from Strongylocentrotus nudus eggs protects against myelosuppression and immunosuppression in cyclophosphamide-treated mice. , Wang H, Wang M, Chen J, Tang Y, Dou J, Yu J, Xi T, Zhou C., Int Immunopharmacol. November 1, 2011; 11 (11): 1946-53.
Turn motif phosphorylation negatively regulates activation loop phosphorylation in Akt. , Hiraoka D, Okumura E, Kishimoto T ., Oncogene. November 3, 2011; 30 (44): 4487-97.
Sulfated polysaccharide isolated from the sea cucumber Stichopus japonicus promotes neurosphere migration and differentiation via up-regulation of N- cadherin. , Sheng X, Li M, Song S, Zhang N, Wang Y , Liang H, Wang W, Ji A., Cell Mol Neurobiol. April 1, 2012; 32 (3): 435-42.
Sphingoid bases from sea cucumber induce apoptosis in human hepatoma HepG2 cells through p- AKT and DR5. , Hossain Z, Sugawara T, Hirata T., Oncol Rep. March 1, 2013; 29 (3): 1201-7.
Sea urchin akt activity is Runx-dependent and required for post-cleavage stage cell division. , Robertson AJ, Coluccio A, Jensen S, Rydlizky K, Coffman JA ., Biol Open. March 25, 2013; 2 (5): 472-8.
Nitrosative/oxidative stress conditions regulate thioredoxin-interacting protein (TXNIP) expression and thioredoxin-1 ( TRX-1) nuclear localization. , Ogata FT, Batista WL, Sartori A, Gesteira TF, Masutani H, Arai RJ, Yodoi J, Stern A, Monteiro HP., PLoS One. December 16, 2013; 8 (12): e84588.
Asterosaponins from the Starfish Astropecten monacanthus suppress growth and induce apoptosis in HL-60, PC-3, and SNU-C5 human cancer cell lines. , Thao NP, Luyen BT, Kim EJ , Kang HK, Kim S, Cuong NX, Nam NH, Kiem PV, Minh CV, Kim YH., Biol Pharm Bull. January 1, 2014; 37 (2): 315-21.
Cyclin B- Cdk1 inhibits protein phosphatase PP2A-B55 via a Greatwall kinase-independent mechanism. , Okumura E, Morita A, Wakai M, Mochida S, Hara M, Kishimoto T ., J Cell Biol. March 17, 2014; 204 (6): 881-9.
Beneficial effects of Ginkgo biloba extract on insulin signaling cascade, dyslipidemia, and body adiposity of diet-induced obese rats. , Banin RM, Hirata BK, Andrade IS, Zemdegs JC, Clemente AP, Dornellas AP, Boldarine VT, Estadella D, Albuquerque KT, Oyama LM, Ribeiro EB, Telles MM., Braz J Med Biol Res. September 1, 2014; 47 (9): 780-8.
Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation. , Bolsoni-Lopes A, Festuccia WT, Chimin P, Farias TS, Torres-Leal FL, Cruz MM, Andrade PB, Hirabara SM, Lima FB, Alonso-Vale MI., Lipids Health Dis. December 20, 2014; 13 199.
Ginkgo biloba extract improves insulin signaling and attenuates inflammation in retroperitoneal adipose tissue depot of obese rats. , Hirata BK, Banin RM, Dornellas AP, de Andrade IS, Zemdegs JC, Caperuto LC, Oyama LM, Ribeiro EB, Telles MM., Mediators Inflamm. January 1, 2015; 2015 419106.
Anticancer activity of sea cucumber triterpene glycosides. , Aminin DL, Menchinskaya ES, Pisliagin EA, Silchenko AS , Avilov SA, Kalinin VI., Mar Drugs. March 6, 2015; 13 (3): 1202-23.
Molecular effects of the phosphatidylinositol-3-kinase inhibitor NVP-BKM120 on T and B-cell acute lymphoblastic leukaemia. , Pereira JK, Machado-Neto JA, Lopes MR, Morini BC, Traina F, Costa FF, Saad ST, Favaro P., Eur J Cancer. September 1, 2015; 51 (14): 2076-85.
Structure-Activity Relationship Study of the Neuritogenic Potential of the Glycan of Starfish Ganglioside LLG-3 (‡). , Yamagishi M, Hosoda-Yabe R, Tamai H, Konishi M, Imamura A, Ishida H, Yabe T, Ando H, Kiso M., Mar Drugs. December 5, 2015; 13 (12): 7250-74.
Neuroprotective effect of sulfated polysaccharide isolated from sea cucumber Stichopus japonicus on 6-OHDA-induced death in SH-SY5Y through inhibition of MAPK and NF-κB and activation of PI3K/ Akt signaling pathways. , Cui C, Cui N, Wang P, Song S, Liang H, Ji A., Biochem Biophys Res Commun. February 5, 2016; 470 (2): 375-383.
IRS2 silencing increases apoptosis and potentiates the effects of ruxolitinib in JAK2V617F-positive myeloproliferative neoplasms. , de Melo Campos P, Machado-Neto JA, Eide CA, Savage SL, Scopim-Ribeiro R, da Silva Souza Duarte A, Favaro P, Lorand-Metze I, Costa FF, Tognon CE, Druker BJ, Olalla Saad ST, Traina F., Oncotarget. February 9, 2016; 7 (6): 6948-59.
Sulfated polysaccharide isolated from the sea cucumber Stichopus japonicas promotes the SDF-1α/CXCR4 axis-induced NSC migration via the PI3K/ Akt/FOXO3a, ERK/MAPK, and NF-κB signaling pathways. , Cui C, Wang P, Cui N, Song S, Liang H, Ji A., Neurosci Lett. March 11, 2016; 616 57-64.
SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice. , Ke M, Wang H, Zhou Y, Li J, Liu Y, Zhang M, Dou J, Xi T, Shen B, Zhou C., Oncotarget. August 2, 2016; 7 (31): 49509-49526.
Two new competing pathways establish the threshold for cyclin-B- Cdk1 activation at the meiotic G2/M transition. , Hiraoka D, Aono R, Hanada S, Okumura E, Kishimoto T ., J Cell Sci. August 15, 2016; 129 (16): 3153-66.
Stichopus japonicus Polysaccharide, Fucoidan, or Heparin Enhanced the SDF-1α/CXCR4 Axis and Promoted NSC Migration via Activation of the PI3K/ Akt/FOXO3a Signaling Pathway. , Cui C, Wang P, Cui N, Song S, Liang H, Ji A., Cell Mol Neurobiol. November 1, 2016; 36 (8): 1311-1329.
Frondoside A from sea cucumber and nymphaeols from Okinawa propolis: Natural anti-cancer agents that selectively inhibit PAK1 in vitro. , Nguyen BCQ, Yoshimura K, Kumazawa S, Tawata S, Maruta H., Drug Discov Ther. May 30, 2017; 11 (2): 110-114.
Acquisition of anoikis resistance promotes alterations in the Ras/ERK and PI3K/ Akt signaling pathways and matrix remodeling in endothelial cells. , de Sousa Mesquita AP, de Araújo Lopes S, Pernambuco Filho PCA, Nader HB, Lopes CC., Apoptosis. September 1, 2017; 22 (9): 1116-1137.
Enhanced antitumor activity of gemcitabine by polysaccharide-induced NK cell activation and immune cytotoxicity reduction in vitro/vivo. , Xie X, Zhou Y, Wang X, Guo J, Li J, Fan H, Dou J, Shen B, Zhou C., Carbohydr Polym. October 1, 2017; 173 360-371.
MPF-based meiotic cell cycle control: Half a century of lessons from starfish oocytes. , Kishimoto T ., Proc Jpn Acad Ser B Phys Biol Sci. January 1, 2018; 94 (4): 180-203.
Function of Thelenota ananas saponin desulfated holothurin A in modulating cholesterol metabolism. , Han QA, Li K, Dong X, Luo Y, Zhu B., Sci Rep. June 22, 2018; 8 (1): 9506.
FoxO4 activity is regulated by phosphorylation and the cellular environment during dehydration in the African clawed frog, Xenopus laevis. , Zhang Y, Luu BE, Storey KB., Biochim Biophys Acta Gen Subj. August 1, 2018; 1862 (8): 1721-1728.
Fungal Immunomodulatory Protein from Nectria haematococca Suppresses Growth of Human Lung Adenocarcinoma by Inhibiting the PI3K/ Akt Pathway. , Xie Y, Li S, Sun L, Liu S, Wang F, Wen B, Sun L, Fang X, Chai Y, Cao H, Jia N, Gu T, Lou X, Xin F., Int J Mol Sci. November 1, 2018; 19 (11):
Comparative toxicity evaluation of targeted anticancer therapeutics in embryonic zebrafish and sea urchin models. , Babic T, Dinic J, Buric SS, Hadzic S, Pesic M, Radojkovic D, Rankov AD., Acta Biol Hung. December 1, 2018; 69 (4): 395-410.
Autophagy and intermittent fasting: the connection for cancer therapy? , Antunes F, Erustes AG, Costa AJ, Nascimento AC, Bincoletto C, Ureshino RP, Pereira GJS, Smaili SS., Clinics (Sao Paulo). December 10, 2018; 73 (suppl 1): e814s.
AKT/ protein kinase B associates with β- actin in the nucleus of melanoma cells. , Coa LL, Abreu TF, Tashima AK, Green J, Pascon RC, Vallim MA, Machado-Jr J., Biosci Rep. January 30, 2019; 39 (1):
Cerebrosides from Sea Cucumber Improved Aβ1-42 -Induced Cognitive Deficiency in a Rat Model of Alzheimer''s Disease. , Li Q, Che HX, Wang CC, Zhang LY , Ding L, Xue CH , Zhang TT, Wang YM ., Mol Nutr Food Res. March 1, 2019; 63 (5): e1800707.
Structural characterization and in vitro hypoglycemic activity of a glucan from Euryale ferox Salisb. seeds. , Zhang WN , Su RN, Gong LL, Yang WW, Chen J, Yang R, Wang Y , Pan WJ, Lu YM, Chen Y., Carbohydr Polym. April 1, 2019; 209 363-371.
In vitro and in vivo Induction of p53-Dependent Apoptosis by Extract of Euryale ferox Salisb in A549 Human Caucasian Lung Carcinoma Cancer Cells Is Mediated Through Akt Signaling Pathway. , Nam GH, Jo KJ, Park YS, Kawk HW, Kim SY, Kim YM., Front Oncol. May 22, 2019; 9 406.
Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat. , Kim R, Hur D, Kim HK, Han J, Mishchenko NP, Fedoreyev SA, Stonik VA, Chang W., Mar Drugs. August 28, 2019; 17 (9):
Immunomodulatory Protein from Nectria haematococca Induces Apoptosis in Lung Cancer Cells via the P53 Pathway. , Wang JJ , Wang Y , Hou L, Xin F, Fan B, Lu C, Zhang L , Wang F, Li S., Int J Mol Sci. October 28, 2019; 20 (21):
Glycosaminoglycan from Apostichopus japonicus inhibits hepatic glucose production via activating Akt/FoxO1 and inhibiting PKA/ CREB signaling pathways in insulin resistant hepatocytes. , Chen Y, Liu H, Wang Y , Yang S, Yu M, Jiang T, Lv Z ., Food Funct. November 1, 2019; 10 (11): 7565-7575.
SGK regulates pH increase and cyclin B- Cdk1 activation to resume meiosis in starfish ovarian oocytes. , Hosoda E, Hiraoka D, Hirohashi N, Omi S, Kishimoto T , Chiba K., J Cell Biol. November 4, 2019; 218 (11): 3612-3629.
Nitric oxide stimulates a PKC-Src- Akt signaling axis which increases human immunodeficiency virus type 1 replication in human T lymphocytes. , Curcio MF, Batista WL, Castro ED, Strumillo ST, Ogata FT, Alkmim W, Brunialti MKC, Salomão R, Turcato G, Diaz RS, Monteiro HP, Janini LMR., Nitric Oxide. December 1, 2019; 93 78-89.
Glycosaminoglycan from Apostichopus japonicus Improves Glucose Metabolism in the Liver of Insulin Resistant Mice. , Chen Y, Wang Y , Yang S, Yu M, Jiang T, Lv Z ., Mar Drugs. December 18, 2019; 18 (1):
A sea cucumber (Holothuria leucospilota) polysaccharide improves the gut microbiome to alleviate the symptoms of type 2 diabetes mellitus in Goto-Kakizaki rats. , Zhao F, Liu Q, Cao J, Xu Y, Pei Z, Fan H, Yuan Y, Shen X, Li C., Food Chem Toxicol. January 1, 2020; 135 110886.
Frondoside A Enhances the Anti-Cancer Effects of Oxaliplatin and 5-Fluorouracil on Colon Cancer Cells. , Attoub S, Arafat K, Khalaf T, Sulaiman S, Iratni R., Nutrients. 10 (5):