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Summary Expression Gene Literature (47) GO Terms (3) Nucleotides (7) Proteins (3) Interactants (126) Wiki

Papers associated with LOC582192

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Frondoside A Enhances the Anti-Cancer Effects of Oxaliplatin and 5-Fluorouracil on Colon Cancer Cells., Attoub S, Arafat K, Khalaf T, Sulaiman S, Iratni R., Nutrients. 10 (5):             

A sea cucumber (Holothuria leucospilota) polysaccharide improves the gut microbiome to alleviate the symptoms of type 2 diabetes mellitus in Goto-Kakizaki rats., Zhao F, Liu Q, Cao J, Xu Y, Pei Z, Fan H, Yuan Y, Shen X, Li C., Food Chem Toxicol. January 1, 2020; 135 110886.

Glycosaminoglycan from Apostichopus japonicus Improves Glucose Metabolism in the Liver of Insulin Resistant Mice., Chen Y, Wang Y, Yang S, Yu M, Jiang T, Lv Z., Mar Drugs. December 18, 2019; 18 (1):               

Nitric oxide stimulates a PKC-Src-Akt signaling axis which increases human immunodeficiency virus type 1 replication in human T lymphocytes., Curcio MF, Batista WL, Castro ED, Strumillo ST, Ogata FT, Alkmim W, Brunialti MKC, Salomão R, Turcato G, Diaz RS, Monteiro HP, Janini LMR., Nitric Oxide. December 1, 2019; 93 78-89.

SGK regulates pH increase and cyclin B-Cdk1 activation to resume meiosis in starfish ovarian oocytes., Hosoda E, Hiraoka D, Hirohashi N, Omi S, Kishimoto T, Chiba K., J Cell Biol. November 4, 2019; 218 (11): 3612-3629.                

Glycosaminoglycan from Apostichopus japonicus inhibits hepatic glucose production via activating Akt/FoxO1 and inhibiting PKA/CREB signaling pathways in insulin resistant hepatocytes., Chen Y, Liu H, Wang Y, Yang S, Yu M, Jiang T, Lv Z., Food Funct. November 1, 2019; 10 (11): 7565-7575.

Immunomodulatory Protein from Nectria haematococca Induces Apoptosis in Lung Cancer Cells via the P53 Pathway., Wang JJ, Wang Y, Hou L, Xin F, Fan B, Lu C, Zhang L, Wang F, Li S., Int J Mol Sci. October 28, 2019; 20 (21):             

Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat., Kim R, Hur D, Kim HK, Han J, Mishchenko NP, Fedoreyev SA, Stonik VA, Chang W., Mar Drugs. August 28, 2019; 17 (9):       

In vitro and in vivo Induction of p53-Dependent Apoptosis by Extract of Euryale ferox Salisb in A549 Human Caucasian Lung Carcinoma Cancer Cells Is Mediated Through Akt Signaling Pathway., Nam GH, Jo KJ, Park YS, Kawk HW, Kim SY, Kim YM., Front Oncol. May 22, 2019; 9 406.            

Structural characterization and in vitro hypoglycemic activity of a glucan from Euryale ferox Salisb. seeds., Zhang WN, Su RN, Gong LL, Yang WW, Chen J, Yang R, Wang Y, Pan WJ, Lu YM, Chen Y., Carbohydr Polym. April 1, 2019; 209 363-371.

Cerebrosides from Sea Cucumber Improved Aβ1-42 -Induced Cognitive Deficiency in a Rat Model of Alzheimer''s Disease., Li Q, Che HX, Wang CC, Zhang LY, Ding L, Xue CH, Zhang TT, Wang YM., Mol Nutr Food Res. March 1, 2019; 63 (5): e1800707.

AKT/protein kinase B associates with β-actin in the nucleus of melanoma cells., Coa LL, Abreu TF, Tashima AK, Green J, Pascon RC, Vallim MA, Machado-Jr J., Biosci Rep. January 30, 2019; 39 (1):                 

Autophagy and intermittent fasting: the connection for cancer therapy?, Antunes F, Erustes AG, Costa AJ, Nascimento AC, Bincoletto C, Ureshino RP, Pereira GJS, Smaili SS., Clinics (Sao Paulo). December 10, 2018; 73 (suppl 1): e814s.  

Comparative toxicity evaluation of targeted anticancer therapeutics in embryonic zebrafish and sea urchin models., Babic T, Dinic J, Buric SS, Hadzic S, Pesic M, Radojkovic D, Rankov AD., Acta Biol Hung. December 1, 2018; 69 (4): 395-410.

Fungal Immunomodulatory Protein from Nectria haematococca Suppresses Growth of Human Lung Adenocarcinoma by Inhibiting the PI3K/Akt Pathway., Xie Y, Li S, Sun L, Liu S, Wang F, Wen B, Sun L, Fang X, Chai Y, Cao H, Jia N, Gu T, Lou X, Xin F., Int J Mol Sci. November 1, 2018; 19 (11):             

FoxO4 activity is regulated by phosphorylation and the cellular environment during dehydration in the African clawed frog, Xenopus laevis., Zhang Y, Luu BE, Storey KB., Biochim Biophys Acta Gen Subj. August 1, 2018; 1862 (8): 1721-1728.

Function of Thelenota ananas saponin desulfated holothurin A in modulating cholesterol metabolism., Han QA, Li K, Dong X, Luo Y, Zhu B., Sci Rep. June 22, 2018; 8 (1): 9506.              

MPF-based meiotic cell cycle control: Half a century of lessons from starfish oocytes., Kishimoto T., Proc Jpn Acad Ser B Phys Biol Sci. January 1, 2018; 94 (4): 180-203.                  

Enhanced antitumor activity of gemcitabine by polysaccharide-induced NK cell activation and immune cytotoxicity reduction in vitro/vivo., Xie X, Zhou Y, Wang X, Guo J, Li J, Fan H, Dou J, Shen B, Zhou C., Carbohydr Polym. October 1, 2017; 173 360-371.

Acquisition of anoikis resistance promotes alterations in the Ras/ERK and PI3K/Akt signaling pathways and matrix remodeling in endothelial cells., de Sousa Mesquita AP, de Araújo Lopes S, Pernambuco Filho PCA, Nader HB, Lopes CC., Apoptosis. September 1, 2017; 22 (9): 1116-1137.

Frondoside A from sea cucumber and nymphaeols from Okinawa propolis: Natural anti-cancer agents that selectively inhibit PAK1 in vitro., Nguyen BCQ, Yoshimura K, Kumazawa S, Tawata S, Maruta H., Drug Discov Ther. May 30, 2017; 11 (2): 110-114.

Stichopus japonicus Polysaccharide, Fucoidan, or Heparin Enhanced the SDF-1α/CXCR4 Axis and Promoted NSC Migration via Activation of the PI3K/Akt/FOXO3a Signaling Pathway., Cui C, Wang P, Cui N, Song S, Liang H, Ji A., Cell Mol Neurobiol. November 1, 2016; 36 (8): 1311-1329.

Two new competing pathways establish the threshold for cyclin-B-Cdk1 activation at the meiotic G2/M transition., Hiraoka D, Aono R, Hanada S, Okumura E, Kishimoto T., J Cell Sci. August 15, 2016; 129 (16): 3153-66.                

SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice., Ke M, Wang H, Zhou Y, Li J, Liu Y, Zhang M, Dou J, Xi T, Shen B, Zhou C., Oncotarget. August 2, 2016; 7 (31): 49509-49526.                  

Sulfated polysaccharide isolated from the sea cucumber Stichopus japonicas promotes the SDF-1α/CXCR4 axis-induced NSC migration via the PI3K/Akt/FOXO3a, ERK/MAPK, and NF-κB signaling pathways., Cui C, Wang P, Cui N, Song S, Liang H, Ji A., Neurosci Lett. March 11, 2016; 616 57-64.

IRS2 silencing increases apoptosis and potentiates the effects of ruxolitinib in JAK2V617F-positive myeloproliferative neoplasms., de Melo Campos P, Machado-Neto JA, Eide CA, Savage SL, Scopim-Ribeiro R, da Silva Souza Duarte A, Favaro P, Lorand-Metze I, Costa FF, Tognon CE, Druker BJ, Olalla Saad ST, Traina F., Oncotarget. February 9, 2016; 7 (6): 6948-59.              

Neuroprotective effect of sulfated polysaccharide isolated from sea cucumber Stichopus japonicus on 6-OHDA-induced death in SH-SY5Y through inhibition of MAPK and NF-κB and activation of PI3K/Akt signaling pathways., Cui C, Cui N, Wang P, Song S, Liang H, Ji A., Biochem Biophys Res Commun. February 5, 2016; 470 (2): 375-383.

Structure-Activity Relationship Study of the Neuritogenic Potential of the Glycan of Starfish Ganglioside LLG-3 (‡)., Yamagishi M, Hosoda-Yabe R, Tamai H, Konishi M, Imamura A, Ishida H, Yabe T, Ando H, Kiso M., Mar Drugs. December 5, 2015; 13 (12): 7250-74.                      

Molecular effects of the phosphatidylinositol-3-kinase inhibitor NVP-BKM120 on T and B-cell acute lymphoblastic leukaemia., Pereira JK, Machado-Neto JA, Lopes MR, Morini BC, Traina F, Costa FF, Saad ST, Favaro P., Eur J Cancer. September 1, 2015; 51 (14): 2076-85.

Anticancer activity of sea cucumber triterpene glycosides., Aminin DL, Menchinskaya ES, Pisliagin EA, Silchenko AS, Avilov SA, Kalinin VI., Mar Drugs. March 6, 2015; 13 (3): 1202-23.                    

Ginkgo biloba extract improves insulin signaling and attenuates inflammation in retroperitoneal adipose tissue depot of obese rats., Hirata BK, Banin RM, Dornellas AP, de Andrade IS, Zemdegs JC, Caperuto LC, Oyama LM, Ribeiro EB, Telles MM., Mediators Inflamm. January 1, 2015; 2015 419106.          

Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation., Bolsoni-Lopes A, Festuccia WT, Chimin P, Farias TS, Torres-Leal FL, Cruz MM, Andrade PB, Hirabara SM, Lima FB, Alonso-Vale MI., Lipids Health Dis. December 20, 2014; 13 199.          

Beneficial effects of Ginkgo biloba extract on insulin signaling cascade, dyslipidemia, and body adiposity of diet-induced obese rats., Banin RM, Hirata BK, Andrade IS, Zemdegs JC, Clemente AP, Dornellas AP, Boldarine VT, Estadella D, Albuquerque KT, Oyama LM, Ribeiro EB, Telles MM., Braz J Med Biol Res. September 1, 2014; 47 (9): 780-8.              

Cyclin B-Cdk1 inhibits protein phosphatase PP2A-B55 via a Greatwall kinase-independent mechanism., Okumura E, Morita A, Wakai M, Mochida S, Hara M, Kishimoto T., J Cell Biol. March 17, 2014; 204 (6): 881-9.          

Asterosaponins from the Starfish Astropecten monacanthus suppress growth and induce apoptosis in HL-60, PC-3, and SNU-C5 human cancer cell lines., Thao NP, Luyen BT, Kim EJ, Kang HK, Kim S, Cuong NX, Nam NH, Kiem PV, Minh CV, Kim YH., Biol Pharm Bull. January 1, 2014; 37 (2): 315-21.

Nitrosative/oxidative stress conditions regulate thioredoxin-interacting protein (TXNIP) expression and thioredoxin-1 (TRX-1) nuclear localization., Ogata FT, Batista WL, Sartori A, Gesteira TF, Masutani H, Arai RJ, Yodoi J, Stern A, Monteiro HP., PLoS One. December 16, 2013; 8 (12): e84588.                  

Sea urchin akt activity is Runx-dependent and required for post-cleavage stage cell division., Robertson AJ, Coluccio A, Jensen S, Rydlizky K, Coffman JA., Biol Open. March 25, 2013; 2 (5): 472-8.          

Sphingoid bases from sea cucumber induce apoptosis in human hepatoma HepG2 cells through p-AKT and DR5., Hossain Z, Sugawara T, Hirata T., Oncol Rep. March 1, 2013; 29 (3): 1201-7.

Sulfated polysaccharide isolated from the sea cucumber Stichopus japonicus promotes neurosphere migration and differentiation via up-regulation of N-cadherin., Sheng X, Li M, Song S, Zhang N, Wang Y, Liang H, Wang W, Ji A., Cell Mol Neurobiol. April 1, 2012; 32 (3): 435-42.

Turn motif phosphorylation negatively regulates activation loop phosphorylation in Akt., Hiraoka D, Okumura E, Kishimoto T., Oncogene. November 3, 2011; 30 (44): 4487-97.

A polysaccharide from Strongylocentrotus nudus eggs protects against myelosuppression and immunosuppression in cyclophosphamide-treated mice., Wang H, Wang M, Chen J, Tang Y, Dou J, Yu J, Xi T, Zhou C., Int Immunopharmacol. November 1, 2011; 11 (11): 1946-53.

A primer on meiotic resumption in starfish oocytes: the proposed signaling pathway triggered by maturation-inducing hormone., Kishimoto T., Mol Reprod Dev. January 1, 2011; 78 (10-11): 704-7.

Hormone-induced cortical maturation ensures the slow block to polyspermy and does not couple with meiotic maturation in starfish., Hirohashi N, Harada K, Chiba K., Dev Biol. June 1, 2008; 318 (1): 194-202.

PKB/AKT is involved in resumption of meiosis in mouse oocytes., Kalous J, Solc P, Baran V, Kubelka M, Schultz RM, Motlik J., Biol Cell. February 1, 2006; 98 (2): 111-23.

PE, a new sulfated saponin from sea cucumber, exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo., Tian F, Zhang X, Tong Y, Yi Y, Zhang S, Li L, Sun P, Lin L, Ding J., Cancer Biol Ther. August 1, 2005; 4 (8): 874-82.

PDK1 is required for the hormonal signaling pathway leading to meiotic resumption in starfish oocytes., Hiraoka D, Hori-Oshima S, Fukuhara T, Tachibana K, Okumura E, Kishimoto T., Dev Biol. December 15, 2004; 276 (2): 330-6.

Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition., Okumura E, Fukuhara T, Yoshida H, Hanada Si S, Kozutsumi R, Mori M, Tachibana K, Kishimoto T., Nat Cell Biol. February 1, 2002; 4 (2): 111-6.

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