Publications By Giovanni Spinelli

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Composition and geographic variation of the bacterial microbiota associated with the coelomic fluid of the sea urchin Paracentrotus lividus., Faddetta T, Ardizzone F, Faillaci F, Reina C, Palazzotto E, Strati F, De Filippo C, Spinelli G, Puglia AM, Gallo G, Cavalieri V., Sci Rep. December 8, 2020; 10 (1): 21443.

Diversification of spatiotemporal expression and copy number variation of the echinoid hbox12/pmar1/micro1 multigene family., Cavalieri V, Geraci F, Spinelli G., PLoS One. March 28, 2017; 12 (3): e0174404.

The Sea Urchin sns5 Chromatin Insulator Shapes the Chromatin Architecture of a Lentivirus Vector Integrated in the Mammalian Genome., Baiamonte E, Spinelli G, Maggio A, Acuto S, Cavalieri V., Nucleic Acid Ther. October 1, 2016; 26 (5): 318-326.

Ectopic hbox12 Expression Evoked by Histone Deacetylase Inhibition Disrupts Axial Specification of the Sea Urchin Embryo., Cavalieri V, Spinelli G., PLoS One. November 3, 2015; 10 (11): e0143860.

Early asymmetric cues triggering the dorsal/ventral gene regulatory network of the sea urchin embryo., Cavalieri V, Spinelli G., Elife. December 2, 2014; 3 e04664.

The Compass-like locus, exclusive to the Ambulacrarians, encodes a chromatin insulator binding protein in the sea urchin embryo., Cavalieri V, Melfi R, Spinelli G., PLoS Genet. January 1, 2013; 9 (9): e1003847.

Specific expression of a TRIM-containing factor in ectoderm cells affects the skeletal morphogenetic program of the sea urchin embryo., Cavalieri V, Guarcello R, Spinelli G., Development. October 1, 2011; 138 (19): 4279-90.

Promoter activity of the sea urchin (Paracentrotus lividus) nucleosomal H3 and H2A and linker H1 {alpha}-histone genes is modulated by enhancer and chromatin insulator., Cavalieri V, Melfi R, Spinelli G., Nucleic Acids Res. December 1, 2009; 37 (22): 7407-15.

The sea urchin sns5 insulator protects retroviral vectors from chromosomal position effects by maintaining active chromatin structure., D'Apolito D, Baiamonte E, Bagliesi M, Di Marzo R, Calzolari R, Ferro L, Franco V, Spinelli G, Maggio A, Acuto S., Mol Ther. August 1, 2009; 17 (8): 1434-41.

The sea urchin embryo: a model to study Alzheimer''s beta amyloid induced toxicity., Pellicanò M, Picone P, Cavalieri V, Carrotta R, Spinelli G, Di Carlo M., Arch Biochem Biophys. March 1, 2009; 483 (1): 120-6.

Functional studies of regulatory genes in the sea urchin embryo., Cavalieri V, Di Bernardo M, Spinelli G., Methods Mol Biol. January 1, 2009; 518 175-88.

cis-Regulatory sequences driving the expression of the Hbox12 homeobox-containing gene in the presumptive aboral ectoderm territory of the Paracentrotus lividus sea urchin embryo., Cavalieri V, Di Bernardo M, Anello L, Spinelli G., Dev Biol. September 15, 2008; 321 (2): 455-69.

EGFR signalling is required for Paracentrotus lividus endomesoderm specification., Romancino DP, Montana G, Cavalieri V, Spinelli G, Di Carlo M., Arch Biochem Biophys. June 1, 2008; 474 (1): 167-74.

Constitutive promoter occupancy by the MBF-1 activator and chromatin modification of the developmental regulated sea urchin alpha-H2A histone gene., Di Caro V, Cavalieri V, Melfi R, Spinelli G., J Mol Biol. February 2, 2007; 365 (5): 1285-97.

Regulatory sequences driving expression of the sea urchin Otp homeobox gene in oral ectoderm cells., Cavalieri V, Bernardo MD, Spinelli G., Gene Expr Patterns. January 1, 2007; 7 (1-2): 124-30.

Functional characterization of the sea urchin sns chromatin insulator in erythroid cells., Acuto S, Di Marzo R, Calzolari R, Baiamonte E, Maggio A, Spinelli G., Blood Cells Mol Dis. January 1, 2005; 35 (3): 339-44.

Down-regulation of early sea urchin histone H2A gene relies on cis regulative sequences located in the 5'' and 3'' regions and including the enhancer blocker sns., Di Caro D, Melfi R, Alessandro C, Serio G, Di Caro V, Cavalieri V, Palla F, Spinelli G., J Mol Biol. October 1, 2004; 342 (5): 1367-77.

Impairing Otp homeodomain function in oral ectoderm cells affects skeletogenesis in sea urchin embryos., Cavalieri V, Spinelli G, Di Bernardo M., Dev Biol. October 1, 2003; 262 (1): 107-18.

The modulator is a constitutive enhancer of a developmentally regulated sea urchin histone H2A gene., Spinelli G, Birnstiel ML., Bioessays. September 1, 2002; 24 (9): 850-7.

Identification of the enhancer binding protein MBF-1 of the sea urchin modulator alpha-H2A histone gene., Alessandro C, Di Simone P, Buscaino A, Anello L, Palla F, Spinelli G., Biochem Biophys Res Commun. July 12, 2002; 295 (2): 519-25.

The sea urchin sns insulator blocks CMV enhancer following integration in human cells., Di Simone P, Di Leonardo A, Costanzo G, Melfi R, Spinelli G., Biochem Biophys Res Commun. June 22, 2001; 284 (4): 987-92.

Functional characterization of the enhancer blocking element of the sea urchin early histone gene cluster reveals insulator properties and three essential cis-acting sequences., Melfi R, Palla F, Di Simone P, Alessandro C, Calì L, Anello L, Spinelli G., J Mol Biol. December 15, 2000; 304 (5): 753-63.

Homeobox genes and sea urchin development., Di Bernardo M, Bellomonte D, Castagnetti S, Melfi R, Oliveri P, Spinelli G., Int J Dev Biol. January 1, 2000; 44 (6): 637-43.

Constitutive hsp70 is essential to mitosis during early cleavage of Paracentrotus lividus embryos: the blockage of constitutive hsp70 impairs mitosis., Sconzo G, Palla F, Agueli C, Spinelli G, Giudice G, Cascino D, Geraci F., Biochem Biophys Res Commun. June 24, 1999; 260 (1): 143-9.

Spatially restricted expression of PlOtp, a Paracentrotus lividus orthopedia-related homeobox gene, is correlated with oral ectodermal patterning and skeletal morphogenesis in late-cleavage sea urchin embryos., Di Bernardo M, Castagnetti S, Bellomonte D, Oliveri P, Melfi R, Palla F, Spinelli G., Development. May 1, 1999; 126 (10): 2171-9.

Regulation of the sea urchin early H2A histone gene expression depends on the modulator element and on sequences located near the 3'' end., Palla F, Melfi R, Di Gaetano L, Bonura C, Anello L, Alessandro C, Spinelli G., Biol Chem. February 1, 1999; 380 (2): 159-65.

Highly restricted expression at the ectoderm-endoderm boundary of PIHbox 9, a sea urchin homeobox gene related to the human HB9 gene., Bellomonte D, Di Bernardo M, Russo R, Caronia G, Spinelli G., Mech Dev. June 1, 1998; 74 (1-2): 185-8.

Sea urchin HSF activity in vitro and in transgenic embryos., Sconzo G, Geraci F, Melfi R, Cascino D, Spinelli G, Giudice G, Sirchia R., Biochem Biophys Res Commun. November 17, 1997; 240 (2): 436-41.

Enhancer blocking activity located near the 3'' end of the sea urchin early H2A histone gene., Palla F, Melfi R, Anello L, Di Bernardo M, Spinelli G., Proc Natl Acad Sci U S A. March 18, 1997; 94 (6): 2272-7.

Homeobox-containing gene transiently expressed in a spatially restricted pattern in the early sea urchin embryo., Di Bernardo M, Russo R, Oliveri P, Melfi R, Spinelli G., Proc Natl Acad Sci U S A. August 29, 1995; 92 (18): 8180-4.

Modulator factor-binding sequence of the sea urchin early histone H2A promoter acts as an enhancer element., Palla F, Bonura C, Anello L, Di Gaetano L, Spinelli G., Proc Natl Acad Sci U S A. December 6, 1994; 91 (25): 12322-6.

Expression of homeobox-containing genes in the sea urchin (Parancentrotus lividus) embryo., Di Bernardo M, Russo R, Oliveri P, Melfi R, Spinelli G., Genetica. January 1, 1994; 94 (2-3): 141-50.

Sea urchin early histone H2A modulator binding factor 1 is a positive transcription factor also for the early histone H3 gene., Palla F, Bonura C, Anello L, Casano C, Ciaccio M, Spinelli G., Proc Natl Acad Sci U S A. July 15, 1993; 90 (14): 6854-8.

Sequence and expression of Paracentrotus lividus alpha tubulin gene., Gianguzza F, Di Bernardo MG, Fais M, Palla F, Casano C, Russo R, Spinelli G., Nucleic Acids Res. August 25, 1990; 18 (16): 4915.

Cis-acting elements of the sea urchin histone H2A modulator bind transcriptional factors., Palla F, Casano C, Albanese I, Anello L, Gianguzza F, Di Bernardo MG, Bonura C, Spinelli G., Proc Natl Acad Sci U S A. August 1, 1989; 86 (16): 6033-7.

Nucleotide sequence of a full length cDNA clone encoding for beta-tubulin of the sea urchin Paracentrotus lividus., Di Bernardo MG, Gianguzza F, Ciaccio M, Palla F, Colombo P, Di Blasi F, Fais M, Spinelli G., Nucleic Acids Res. July 25, 1989; 17 (14): 5851.

DNA sequence and pattern of expression of the sea urchin (Paracentrotus lividus) alpha-tubulin genes., Gianguzza F, Di Bernardo MG, Sollazzo M, Palla F, Ciaccio M, Carra E, Spinelli G., Mol Reprod Dev. January 1, 1989; 1 (3): 170-81.

Different micrococcal nuclease cleavage patterns characterize transcriptionally active and inactive sea-urchin histone genes., Anello L, Albanese I, Casano C, Palla F, Gianguzza F, Di Bernardo MG, Di Marzo R, Spinelli G., Eur J Biochem. April 15, 1986; 156 (2): 367-74.

Chromatin structure of histone genes in sea urchin sperms and embryos., Spinelli G, Albanese I, Anello L, Ciaccio M, Di Liegro I., Nucleic Acids Res. December 20, 1982; 10 (24): 7977-91.

Transcription of sea-urchin mesenchyme blastula histone genes after heat shock., Spinelli G, Casano C, Gianguzza F, Ciaccio M, Palla F., Eur J Biochem. November 15, 1982; 128 (2-3): 509-13.

Some effects of heat shock on the regulation of macromolecular syntheses in sea urchin embryos., Roccheri MC, Spinelli G, Sconzo G, Casano C, Giudice G., Prog Clin Biol Res. January 1, 1982; 85 Pt B 31-43.

High molecular weight RNA containing histone messenger in the sea urchin Paracentrotus lividus., Spinelli G, Melli M, Arnold E, Casano C, Gianguzza F, Ciaccio M., J Mol Biol. May 15, 1980; 139 (2): 111-22.

Evidences of two different sets of histone genes active during embryogenesis of the sea urchin Paracentrotus lividus., Spinelli G, Gianguzza F, Casano C, Acierno P, Burckhardt J., Nucleic Acids Res. February 1, 1979; 6 (2): 545-60.

Synthesis of histone messenger RNA of HeLa cells during the cell cycle., Melli M, Spinelli G, Arnold E., Cell. September 1, 1977; 12 (1): 167-74.

Presence of histone mRNA sequences in high molecular weight RNA of HeLa cells., Melli M, Spinelli G, Wyssling H, Arnold E., Cell. July 1, 1977; 11 (3): 651-61.

The RNA of unfertilized sea urchin eggs is "capped"., Pirrone AM, Spinelli G, Acierno P, Errera M, Giudice G., Cell Differ. March 1, 1977; 5 (5-6): 335-42.

Synthesis of histones during sea urchin oogenesis., Cognetti G, Spinelli G, Vivoli A., Biochim Biophys Acta. May 31, 1974; 349 (3): 447-55.

Developmental changes of chromatin non-histone proteins in sea urchins., Cognetti G, Settineri D, Spinelli G., Exp Cell Res. January 1, 1972; 71 (2): 465-8.

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