Results 1 - 50 of 81 results
NAADP-Mediated Ca2+ Signalling. , Galione A , Davis LC, Martucci LL, Morgan AJ., Handb Exp Pharmacol. July 26, 2022;
Carvedilol inhibits cADPR- and IP3-induced Ca2+ release. , Morgan AJ, Bampali K, Ruas M, Factor C, Back TG, Chen SRW, Galione A ., Messenger (Los Angel). June 1, 2016; 5 (1-2): 92-99.
A primer of NAADP-mediated Ca(2+) signalling: From sea urchin eggs to mammalian cells. , Galione A ., Cell Calcium. July 1, 2015; 58 (1): 27-47.
Measurement of luminal pH of acidic stores as a readout for NAADP action. , Galione A , Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC., Cold Spring Harb Protoc. October 1, 2014; 2014 (10): pdb.prot076935.
Preparation and use of sea urchin egg homogenates for studying NAADP-mediated Ca²⁺ release. , Galione A , Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC., Cold Spring Harb Protoc. September 2, 2014; 2014 (9): 988-92.
''Click cyclic ADP-ribose'': a neutral second messenger mimic. , Swarbrick JM, Graeff R, Garnham C, Thomas MP, Galione A , Potter BV., Chem Commun (Camb). March 7, 2014; 50 (19): 2458-61.
Preparation and use of sea urchin egg homogenates. , Morgan AJ, Galione A ., Methods Mol Biol. January 1, 2014; 1128 161-73.
Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles. , Morgan AJ, Davis LC, Wagner SK, Lewis AM, Parrington J, Churchill GC, Galione A ., J Cell Biol. March 18, 2013; 200 (6): 789-805.
The luminal Ca(2+) chelator, TPEN, inhibits NAADP-induced Ca(2+) release. , Morgan AJ, Parrington J, Galione A ., Cell Calcium. December 1, 2012; 52 (6): 481-7.
Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg. , Walseth TF, Lin-Moshier Y, Jain P, Ruas M, Parrington J, Galione A , Marchant JS, Slama JT., J Biol Chem. January 20, 2012; 287 (4): 2308-15.
Synthesis of cyclic adenosine 5''-diphosphate ribose analogues: a C2''endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor. , Moreau C, Ashamu GA, Bailey VC, Galione A , Guse AH, Potter BV., Org Biomol Chem. January 7, 2011; 9 (1): 278-90.
NAADP receptors. , Galione A ., Cold Spring Harb Perspect Biol. January 1, 2011; 3 (1): a004036.
The calcium-mobilizing messenger nicotinic acid adenine dinucleotide phosphate participates in sperm activation by mediating the acrosome reaction. , Vasudevan SR, Lewis AM, Chan JW, Machin CL, Sinha D, Galione A , Churchill GC., J Biol Chem. June 11, 2010; 285 (24): 18262-9.
Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking. , Ruas M, Rietdorf K, Arredouani A, Davis LC, Lloyd-Evans E, Koegel H, Funnell TM, Morgan AJ, Ward JA, Watanabe K, Cheng X, Churchill GC, Zhu MX, Platt FM, Wessel GM , Parrington J, Galione A ., Curr Biol. April 27, 2010; 20 (8): 703-9.
Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor. , Rosen D, Lewis AM, Mizote A, Thomas JM, Aley PK, Vasudevan SR, Parkesh R, Galione A , Izumi M, Ganesan A, Churchill GC., J Biol Chem. December 11, 2009; 284 (50): 34930-4.
Identification of a chemical probe for NAADP by virtual screening. , Naylor E, Arredouani A, Vasudevan SR, Lewis AM, Parkesh R, Mizote A, Rosen D, Thomas JM, Izumi M, Ganesan A, Galione A , Churchill GC., Nat Chem Biol. April 1, 2009; 5 (4): 220-6.
Investigating cADPR and NAADP in intact and broken cell preparations. , Morgan AJ, Galione A ., Methods. November 1, 2008; 46 (3): 194-203.
Ca(2+) signaling occurs via second messenger release from intraorganelle synthesis sites. , Davis LC, Morgan AJ, Ruas M, Wong JL, Graeff RM, Poustka AJ, Lee HC, Wessel GM , Parrington J, Galione A ., Curr Biol. October 28, 2008; 18 (20): 1612-8.
Cell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cells. , Parkesh R, Lewis AM, Aley PK, Arredouani A, Rossi S, Tavares R, Vasudevan SR, Rosen D, Galione A , Dowden J, Churchill GC., Cell Calcium. June 1, 2008; 43 (6): 531-8.
Sperm express a Ca2+-regulated NAADP synthase. , Vasudevan SR, Galione A , Churchill GC., Biochem J. April 1, 2008; 411 (1): 63-70.
2''-deoxy cyclic adenosine 5''-diphosphate ribose derivatives: importance of the 2''-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives. , Zhang B, Wagner GK, Weber K, Garnham C, Morgan AJ, Galione A , Guse AH, Potter BV., J Med Chem. March 27, 2008; 51 (6): 1623-36.
Fertilization and nicotinic acid adenine dinucleotide phosphate induce pH changes in acidic Ca(2+) stores in sea urchin eggs. , Morgan AJ, Galione A ., J Biol Chem. December 28, 2007; 282 (52): 37730-7.
Refinement of a radioreceptor binding assay for nicotinic acid adenine dinucleotide phosphate. , Lewis AM, Masgrau R, Vasudevan SR, Yamasaki M, O'Neill JS, Garnham C, James K, Macdonald A, Ziegler M, Galione A , Churchill GC., Anal Biochem. December 1, 2007; 371 (1): 26-36.
Flipping the switch: how a sperm activates the egg at fertilization. , Parrington J, Davis LC, Galione A , Wessel G ., Dev Dyn. August 1, 2007; 236 (8): 2027-38.
NAADP induces pH changes in the lumen of acidic Ca2+ stores. , Morgan AJ, Galione A ., Biochem J. March 1, 2007; 402 (2): 301-10.
Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+). , Parkesh R, Vasudevan SR, Berry A, Galione A , Dowden J, Churchill GC., Org Biomol Chem. February 7, 2007; 5 (3): 441-3.
NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores. , Galione A ., Biochem Soc Trans. November 1, 2006; 34 (Pt 5): 922-6.
Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release. , Dowden J, Berridge G, Moreau C, Yamasaki M, Churchill GC, Potter BV, Galione A ., Chem Biol. June 1, 2006; 13 (6): 659-65.
Endogenously bound calmodulin is essential for the function of the inositol 1,4,5-trisphosphate receptor. , Kasri NN, Török K, Galione A , Garnham C, Callewaert G, Missiaen L, Parys JB, De Smedt H., J Biol Chem. March 31, 2006; 281 (13): 8332-8.
Role of NAADP and cADPR in the induction and maintenance of agonist-evoked Ca2+ spiking in mouse pancreatic acinar cells. , Yamasaki M, Thomas JM, Churchill GC, Garnham C, Lewis AM, Cancela JM, Patel S, Galione A ., Curr Biol. May 10, 2005; 15 (9): 874-8.
The NAADP receptor: new receptors or new regulation? , Galione A , Petersen OH., Mol Interv. April 1, 2005; 5 (2): 73-9.
NAADP receptors. , Galione A , Ruas M., Cell Calcium. January 1, 2005; 38 (3-4): 273-80.
Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate. , Dowden J, Moreau C, Brown RS, Berridge G, Galione A , Potter BV., Angew Chem Int Ed Engl. September 6, 2004; 43 (35): 4637-40.
The NAADP receptor: commentary on Billington et al. , Galione A , Parrington J, Dowden J., Br J Pharmacol. August 1, 2004; 142 (8): 1203-7.
Aplysia californica mediated cyclisation of novel 3''-modified NAD+ analogues: a role for hydrogen bonding in the recognition of cyclic adenosine 5''-diphosphate ribose. , Mort CJ, Migaud ME, Galione A , Potter BV., Bioorg Med Chem. January 15, 2004; 12 (2): 475-87.
Convergent synthesis and unexpected Ca(2+)-mobilizing activity of 8-substituted analogues of cyclic ADP-carbocyclic-ribose, a stable mimic of the Ca(2+)-mobilizing second messenger cyclic ADP-ribose. , Shuto S, Fukuoka M, Kudoh T, Garnham C, Galione A , Potter BV, Matsuda A., J Med Chem. October 23, 2003; 46 (22): 4741-9.
The NO pathway acts late during the fertilization response in sea urchin eggs. , Leckie C, Empson R, Becchetti A, Thomas J, Galione A , Whitaker M ., J Biol Chem. April 4, 2003; 278 (14): 12247-54.
Sperm deliver a new second messenger: NAADP. , Churchill GC, O'Neill JS, Masgrau R, Patel S, Thomas JM, Genazzani AA, Galione A ., Curr Biol. January 21, 2003; 13 (2): 125-8.
Calmodulin dissociation mediates desensitization of the cADPR-induced Ca2+ release mechanism. , Thomas JM, Summerhill RJ, Fruen BR, Churchill GC, Galione A ., Curr Biol. December 10, 2002; 12 (23): 2018-22.
NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs. , Churchill GC, Okada Y, Thomas JM, Genazzani AA, Patel S, Galione A ., Cell. November 27, 2002; 111 (5): 703-8.
Solubilization of receptors for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate. , Berridge G, Dickinson G, Parrington J, Galione A , Patel S., J Biol Chem. November 15, 2002; 277 (46): 43717-23.
Interactions between calcium release pathways: multiple messengers and multiple stores. , Galione A , Churchill GC., Cell Calcium. January 1, 2002; 32 (5-6): 343-54.
Pharmacological characterization of the putative cADP-ribose receptor. , Thomas JM, Masgrau R, Churchill GC, Galione A ., Biochem J. October 15, 2001; 359 (Pt 2): 451-7.
Distinct pharmacology of 2-hydroxycarbazole-induced Ca2+ release in the sea urchin egg. , Thomas JM, Churchill GC, Patel S, Galione A ., J Pharmacol Exp Ther. August 1, 2001; 298 (2): 644-50.
NAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ stores. , Churchill GC, Galione A ., EMBO J. June 1, 2001; 20 (11): 2666-71.
Prolonged inactivation of nicotinic acid adenine dinucleotide phosphate-induced Ca2+ release mediates a spatiotemporal Ca2+ memory. , Churchill GC, Galione A ., J Biol Chem. April 6, 2001; 276 (14): 11223-5.
Unique kinetics of nicotinic acid-adenine dinucleotide phosphate (NAADP) binding enhance the sensitivity of NAADP receptors for their ligand. , Patel S, Churchill GC, Galione A ., Biochem J. December 15, 2000; 352 Pt 3 725-9.
Spatial control of Ca2+ signaling by nicotinic acid adenine dinucleotide phosphate diffusion and gradients. , Churchill GC, Galione A ., J Biol Chem. December 8, 2000; 275 (49): 38687-92.
Widespread distribution of binding sites for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate, in the brain. , Patel S, Churchill GC, Sharp T, Galione A ., J Biol Chem. November 24, 2000; 275 (47): 36495-7.
Calcium release from the endoplasmic reticulum of higher plants elicited by the NADP metabolite nicotinic acid adenine dinucleotide phosphate. , Navazio L, Bewell MA, Siddiqua A, Dickinson GD, Galione A , Sanders D., Proc Natl Acad Sci U S A. July 18, 2000; 97 (15): 8693-8.