William H Klein - Publications

Publications (64)

ECB-PERS-4182

Publications By William H Klein

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Substituting mouse transcription factor Pou4f2 with a sea urchin orthologue restores retinal ganglion cell development., Mao CA, Agca C, Mocko-Strand JA, Wang J, Ullrich-Lüter E, Pan P, Wang SW, Arnone MI, Frishman LJ, Klein WH., Proc Biol Sci. March 16, 2016; 283 (1826): 20152978.
Neurosensory and neuromuscular organization in tube feet of the sea urchin Strongylocentrotus purpuratus., Agca C, Elhajj MC, Klein WH, Venuti JM., J Comp Neurol. December 1, 2011; 519 (17): 3566-79.
Reduced O2 and elevated ROS in sea urchin embryos leads to defects in ectoderm differentiation., Agca C, Klein WH, Venuti JM., Dev Dyn. July 1, 2009; 238 (7): 1777-87.
Intragenomic evolution of a transcriptional enhancer in the genome of Strongylocentrotus purpuratus., Kiyama T, Zhang J, Liang S, Liang S, Klein WH., Mar Genomics. June 1, 2009; 2 (2): 85-98.
Respecification of ectoderm and altered Nodal expression in sea urchin embryos after cobalt and nickel treatment., Agca C, Klein WH, Venuti JM., Mech Dev. January 1, 2009; 126 (5-6): 430-42.
SpGataE, a Strongylocentrotus purpuratus ortholog of mammalian Gata4/5/6: protein expression, interaction with putative target gene spec2a, and identification of friend of Gata factor SpFog1., Kiyama T, Klein WH., Dev Genes Evol. September 1, 2007; 217 (9): 651-63.
A genomic view of the sea urchin nervous system., Burke RD, Angerer LM, Elphick MR, Humphrey GW, Yaguchi S, Kiyama T, Liang S, Mu X, Agca C, Klein WH, Brandhorst BP, Rowe M, Wilson K, Churcher AM, Taylor JS, Chen N, Murray G, Wang D, Mellott D, Olinski R, Hallböök F, Thorndyke MC., Dev Biol. December 1, 2006; 300 (1): 434-60.
The genome of the sea urchin Strongylocentrotus purpuratus., Sea Urchin Genome Sequencing Consortium, Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO, Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC, Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O, Hlavina W, Hofmann G, Kitts P, Landrum MJ, Mackey AJ, Maglott D, Panopoulou G, Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z, Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R, Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A, Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Bellé R, Carbonneau S, Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Genevière AM, Goel M, Kelkar H, Morales J, Mulner-Lorillon O, Robertson AJ, Goldstone JV, Cole B, Epel D, Gold B, Hahn ME, Howard-Ashby M, Scally M, Stegeman JJ, Allgood EL, Cool J, Judkins KM, McCafferty SS, Musante AM, Obar RA, Rawson AP, Rossetti BJ, Gibbons IR, Hoffman MP, Leone A, Istrail S, Materna SC, Samanta MP, Stolc V, Tongprasit W, Tu Q, Bergeron KF, Brandhorst BP, Whittle J, Berney K, Bottjer DJ, Calestani C, Peterson K, Chow E, Yuan QA, Elhaik E, Graur D, Reese JT, Bosdet I, Heesun S, Marra MA, Schein J, Anderson MK, Brockton V, Buckley KM, Cohen AH, Fugmann SD, Hibino T, Loza-Coll M, Majeske AJ, Messier C, Nair SV, Pancer Z, Terwilliger DP, Agca C, Arboleda E, Chen N, Churcher AM, Hallböök F, Humphrey GW, Idris MM, Kiyama T, Liang S, Mellott D, Mu X, Murray G, Olinski RP, Raible F, Rowe M, Taylor JS, Tessmar-Raible K, Wang D, Wilson KH, Yaguchi S, Gaasterland T, Galindo BE, Gunaratne HJ, Juliano C, Kinukawa M, Moy GW, Neill AT, Nomura M, Raisch M, Reade A, Roux MM, Song JL, Su YH, Townley IK, Voronina E, Wong JL, Amore G, Branno M, Brown ER, Cavalieri V, Duboc V, Duloquin L, Flytzanis C, Gache C, Lapraz F, Lepage T, Locascio A, Martinez P, Matassi G, Matranga V, Range R, Rizzo F, Röttinger E, Beane W, Bradham C, Byrum C, Glenn T, Hussain S, Manning G, Miranda E, Thomason R, Walton K, Wikramanayke A, Wu SY, Xu R, Brown CT, Chen L, Gray RF, Lee PY, Nam J, Oliveri P, Smith J, Muzny D, Bell S, Chacko J, Cree A, Curry S, Davis C, Dinh H, Dugan-Rocha S, Fowler J, Gill R, Hamilton C, Hernandez J, Hines S, Hume J, Jackson L, Jolivet A, Kovar C, Lee S, Lewis L, Miner G, Morgan M, Nazareth LV, Okwuonu G, Parker D, Pu LL, Thorn R, Wright R., Science. November 10, 2006; 314 (5801): 941-52.
Structure, expression, and transcriptional regulation of the Strongylocentrotus franciscanus spec gene family encoding intracellular calcium-binding proteins., Villinski JT, Kiyama T, Dayal S, Zhang N, Liang S, Klein WH., Dev Genes Evol. August 1, 2005; 215 (8): 410-22.
Strongylocentrotus purpuratus transcription factor GATA-E binds to and represses transcription at an Otx-Goosecoid cis-regulatory element within the aboral ectoderm-specific spec2a enhancer., Kiyama T, Zhang N, Dayal S, Yun Lee P, Liang S, Villinski JT, Klein WH., Dev Biol. April 15, 2005; 280 (2): 436-47.
Creation of cis-regulatory elements during sea urchin evolution by co-option and optimization of a repetitive sequence adjacent to the spec2a gene., Dayal S, Kiyama T, Villinski JT, Zhang N, Liang S, Klein WH., Dev Biol. September 15, 2004; 273 (2): 436-53.
Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages., Wikramanayake AH, Peterson R, Chen J, Huang L, Bince JM, McClay DR, Klein WH., Genesis. July 1, 2004; 39 (3): 194-205.
Ectoderm gene activation in sea urchin embryos mediated by the CCAAT-binding factor., Li X, Bhattacharya C, Dayal S, Maity S, Klein WH., Differentiation. May 1, 2002; 70 (2-3): 109-19.
Molecular patterning along the sea urchin animal-vegetal axis., Brandhorst BP, Klein WH., Int Rev Cytol. January 1, 2002; 213 183-232.
Sea urchin goosecoid function links fate specification along the animal-vegetal and oral-aboral embryonic axes., Angerer LM, Oleksyn DW, Levine AM, Li X, Klein WH, Angerer RC., Development. November 1, 2001; 128 (22): 4393-404.
Correct Expression of spec2a in the sea urchin embryo requires both Otx and other cis-regulatory elements., Yuh CH, Li X, Davidson EH, Klein WH., Dev Biol. April 15, 2001; 232 (2): 424-38.
Involvement of Tcf/Lef in establishing cell types along the animal-vegetal axis of sea urchins., Huang L, Li X, El-Hodiri HM, Dayal S, Wikramanayake AH, Klein WH., Dev Genes Evol. February 1, 2000; 210 (2): 73-81.
Requirement of SpOtx in cell fate decisions in the sea urchin embryo and possible role as a mediator of beta-catenin signaling., Li X, Wikramanayake AH, Klein WH., Dev Biol. August 15, 1999; 212 (2): 425-39.
Function and evolution of Otx proteins., Klein WH, Li X., Biochem Biophys Res Commun. May 10, 1999; 258 (2): 229-33.
beta-Catenin is essential for patterning the maternally specified animal-vegetal axis in the sea urchin embryo., Wikramanayake AH, Huang L, Klein WH., Proc Natl Acad Sci U S A. August 4, 1998; 95 (16): 9343-8.
Two Otx proteins generated from multiple transcripts of a single gene in Strongylocentrotus purpuratus., Li X, Chuang CK, Mao CA, Angerer LM, Klein WH., Dev Biol. July 15, 1997; 187 (2): 253-66.
Multiple signaling events specify ectoderm and pattern the oral-aboral axis in the sea urchin embryo., Wikramanayake AH, Klein WH., Development. January 1, 1997; 124 (1): 13-20.
Very early and transient vegetal-plate expression of SpKrox1, a Krüppel/Krox gene from Stronglyocentrotus purpuratus., Wang W, Wikramanayake AH, Gonzalez-Rimbau M, Vlahou A, Flytzanis CN, Klein WH., Mech Dev. December 1, 1996; 60 (2): 185-95.
Altering cell fates in sea urchin embryos by overexpressing SpOtx, an orthodenticle-related protein., Mao CA, Wikramanayake AH, Gan L, Chuang CK, Summers RG, Klein WH., Development. May 1, 1996; 122 (5): 1489-98.
A G/C-rich DNA-regulatory element controls positive expression of the sea urchin Lytechinus pictus aboral ectoderm-specific LpS1 gene., Wang W, Klein WH., DNA Cell Biol. February 1, 1996; 15 (2): 133-45.
Transient appearance of Strongylocentrotus purpuratus Otx in micromere nuclei: cytoplasmic retention of SpOtx possibly mediated through an alpha-actinin interaction., Chuang CK, Wikramanayake AH, Mao CA, Li X, Klein WH., Dev Genet. January 1, 1996; 19 (3): 231-7.
Autonomous and non-autonomous differentiation of ectoderm in different sea urchin species., Wikramanayake AH, Brandhorst BP, Klein WH., Development. May 1, 1995; 121 (5): 1497-505.
An orthodenticle-related protein from Strongylocentrotus purpuratus., Gan L, Mao CA, Wikramanayake A, Angerer LM, Angerer RC, Klein WH., Dev Biol. February 1, 1995; 167 (2): 517-28.
Multiple Otx binding sites required for expression of the Strongylocentrotus purpuratus Spec2a gene., Mao CA, Gan L, Klein WH., Dev Biol. September 1, 1994; 165 (1): 229-42.
A positive cis-regulatory element with a bicoid target site lies within the sea urchin Spec2a enhancer., Gan L, Klein WH., Dev Biol. May 1, 1993; 157 (1): 119-32.
Developmental potential of muscle cell progenitors and the myogenic factor SUM-1 in the sea urchin embryo., Venuti JM, Gan L, Kozlowski MT, Klein WH., Mech Dev. April 1, 1993; 41 (1): 3-14.
Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers., Sirito M, Walker S, Lin Q, Kozlowski MT, Klein WH, Sawadogo M., Gene Expr. January 1, 1992; 2 (3): 231-40.
Sea urchin USF: a helix-loop-helix protein active in embryonic ectoderm cells., Kozlowski MT, Gan L, Venuti JM, Sawadogo M, Klein WH., Dev Biol. December 1, 1991; 148 (2): 625-30.
A G-string positive cis-regulatory element in the LpS1 promoter binds two distinct nuclear factors distributed non-uniformly in Lytechinus pictus embryos., Xiang M, Lu SY, Musso M, Karsenty G, Klein WH., Development. December 1, 1991; 113 (4): 1345-55.
A myogenic factor from sea urchin embryos capable of programming muscle differentiation in mammalian cells., Venuti JM, Goldberg L, Chakraborty T, Olson EN, Klein WH., Proc Natl Acad Sci U S A. July 15, 1991; 88 (14): 6219-23.
Structure and promoter activity of the LpS1 genes of Lytechinus pictus. Duplicated exons account for LpS1 proteins with eight calcium binding domains., Xiang MQ, Ge T, Tomlinson CR, Klein WH., J Biol Chem. June 5, 1991; 266 (16): 10524-33.
Regulatory elements from the related spec genes of Strongylocentrotus purpuratus yield different spatial patterns with a lacZ reporter gene., Gan L, Wessel GM, Klein WH., Dev Biol. December 1, 1990; 142 (2): 346-59.
Ectoderm nuclei from sea urchin embryos contain a Spec-DNA binding protein similar to the vertebrate transcription factor USF., Tomlinson CR, Kozlowski MT, Klein WH., Development. September 1, 1990; 110 (1): 259-72.
Myosin heavy chain accumulates in dissimilar cell types of the macromere lineage in the sea urchin embryo., Wessel GM, Zhang W, Klein WH., Dev Biol. August 1, 1990; 140 (2): 447-54.
Repetitive DNA sequences linked to the sea urchin spec genes contain transcriptional enhancer-like elements., Gan L, Zhang W, Klein WH., Dev Biol. May 1, 1990; 139 (1): 186-96.
Temporal and spatial transcriptional regulation of the aboral ectoderm-specific Spec genes during sea urchin embryogenesis., Tomlinson CR, Klein WH., Mol Reprod Dev. April 1, 1990; 25 (4): 328-38.
Localization of the sea urchin Spec3 protein to cilia and Golgi complexes of embryonic ectoderm cells., Eldon ED, Montpetit IC, Nguyen T, Decker G, Valdizan MC, Klein WH, Brandhorst BP., Genes Dev. January 1, 1990; 4 (1): 111-22.
Gastrulation in the sea urchin is accompanied by the accumulation of an endoderm-specific mRNA., Wessel GM, Goldberg L, Lennarz WJ, Klein WH., Dev Biol. December 1, 1989; 136 (2): 526-36.
Transcription of the Spec 1-like gene of Lytechinus is selectively inhibited in response to disruption of the extracellular matrix., Wessel GM, Zhang W, Tomlinson CR, Lennarz WJ, Klein WH., Development. June 1, 1989; 106 (2): 355-65.
Tandem duplication and divergence of a sea urchin protein belonging to the troponin C superfamily., Xiang MQ, Bédard PA, Wessel G, Filion M, Brandhorst BP, Klein WH., J Biol Chem. November 15, 1988; 263 (32): 17173-80.
Spec2 genes of Strongylocentrotus purpuratus. Structure and differential expression in embryonic aboral ectoderm cells., Hardin PE, Angerer LM, Hardin SH, Angerer RC, Klein WH., J Mol Biol. August 5, 1988; 202 (3): 417-31.
Spec3: embryonic expression of a sea urchin gene whose product is involved in ectodermal ciliogenesis., Eldon ED, Angerer LM, Angerer RC, Klein WH., Genes Dev. December 1, 1987; 1 (10): 1280-92.
Use of consensus oligonucleotides for detecting and isolating nucleic acids encoding calcium binding domains of the troponin C superfamily., Hardin SH, Keast MJ, Hardin PE, Klein WH., Biochemistry. June 16, 1987; 26 (12): 3518-23.
Unusual sequence conservation in the 5'' and 3'' untranslated regions of the sea urchin spec mRNAs., Hardin PE, Klein WH., J Mol Evol. January 1, 1987; 25 (2): 126-33.
Calmodulin gene expression during sea urchin development: persistence of a prevalent maternal protein., Floyd EE, Gong ZY, Brandhorst BP, Klein WH., Dev Biol. February 1, 1986; 113 (2): 501-11.

Substituting mouse transcription factor Pou4f2 with a sea urchin orthologue restores retinal ganglion cell development., Mao CA, Agca C, Mocko-Strand JA, Wang J, Ullrich-Lüter E, Pan P, Wang SW, Arnone MI, Frishman LJ, Klein WH., Proc Biol Sci. March 16, 2016; 283 (1826): 20152978.

Neurosensory and neuromuscular organization in tube feet of the sea urchin Strongylocentrotus purpuratus., Agca C, Elhajj MC, Klein WH, Venuti JM., J Comp Neurol. December 1, 2011; 519 (17): 3566-79.

Reduced O2 and elevated ROS in sea urchin embryos leads to defects in ectoderm differentiation., Agca C, Klein WH, Venuti JM., Dev Dyn. July 1, 2009; 238 (7): 1777-87.

Intragenomic evolution of a transcriptional enhancer in the genome of Strongylocentrotus purpuratus., Kiyama T, Zhang J, Liang S, Liang S, Klein WH., Mar Genomics. June 1, 2009; 2 (2): 85-98.

Respecification of ectoderm and altered Nodal expression in sea urchin embryos after cobalt and nickel treatment., Agca C, Klein WH, Venuti JM., Mech Dev. January 1, 2009; 126 (5-6): 430-42.

SpGataE, a Strongylocentrotus purpuratus ortholog of mammalian Gata4/5/6: protein expression, interaction with putative target gene spec2a, and identification of friend of Gata factor SpFog1., Kiyama T, Klein WH., Dev Genes Evol. September 1, 2007; 217 (9): 651-63.

A genomic view of the sea urchin nervous system., Burke RD, Angerer LM, Elphick MR, Humphrey GW, Yaguchi S, Kiyama T, Liang S, Mu X, Agca C, Klein WH, Brandhorst BP, Rowe M, Wilson K, Churcher AM, Taylor JS, Chen N, Murray G, Wang D, Mellott D, Olinski R, Hallböök F, Thorndyke MC., Dev Biol. December 1, 2006; 300 (1): 434-60.

The genome of the sea urchin Strongylocentrotus purpuratus., Sea Urchin Genome Sequencing Consortium, Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO, Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC, Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O, Hlavina W, Hofmann G, Kitts P, Landrum MJ, Mackey AJ, Maglott D, Panopoulou G, Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z, Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R, Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A, Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Bellé R, Carbonneau S, Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Genevière AM, Goel M, Kelkar H, Morales J, Mulner-Lorillon O, Robertson AJ, Goldstone JV, Cole B, Epel D, Gold B, Hahn ME, Howard-Ashby M, Scally M, Stegeman JJ, Allgood EL, Cool J, Judkins KM, McCafferty SS, Musante AM, Obar RA, Rawson AP, Rossetti BJ, Gibbons IR, Hoffman MP, Leone A, Istrail S, Materna SC, Samanta MP, Stolc V, Tongprasit W, Tu Q, Bergeron KF, Brandhorst BP, Whittle J, Berney K, Bottjer DJ, Calestani C, Peterson K, Chow E, Yuan QA, Elhaik E, Graur D, Reese JT, Bosdet I, Heesun S, Marra MA, Schein J, Anderson MK, Brockton V, Buckley KM, Cohen AH, Fugmann SD, Hibino T, Loza-Coll M, Majeske AJ, Messier C, Nair SV, Pancer Z, Terwilliger DP, Agca C, Arboleda E, Chen N, Churcher AM, Hallböök F, Humphrey GW, Idris MM, Kiyama T, Liang S, Mellott D, Mu X, Murray G, Olinski RP, Raible F, Rowe M, Taylor JS, Tessmar-Raible K, Wang D, Wilson KH, Yaguchi S, Gaasterland T, Galindo BE, Gunaratne HJ, Juliano C, Kinukawa M, Moy GW, Neill AT, Nomura M, Raisch M, Reade A, Roux MM, Song JL, Su YH, Townley IK, Voronina E, Wong JL, Amore G, Branno M, Brown ER, Cavalieri V, Duboc V, Duloquin L, Flytzanis C, Gache C, Lapraz F, Lepage T, Locascio A, Martinez P, Matassi G, Matranga V, Range R, Rizzo F, Röttinger E, Beane W, Bradham C, Byrum C, Glenn T, Hussain S, Manning G, Miranda E, Thomason R, Walton K, Wikramanayke A, Wu SY, Xu R, Brown CT, Chen L, Gray RF, Lee PY, Nam J, Oliveri P, Smith J, Muzny D, Bell S, Chacko J, Cree A, Curry S, Davis C, Dinh H, Dugan-Rocha S, Fowler J, Gill R, Hamilton C, Hernandez J, Hines S, Hume J, Jackson L, Jolivet A, Kovar C, Lee S, Lewis L, Miner G, Morgan M, Nazareth LV, Okwuonu G, Parker D, Pu LL, Thorn R, Wright R., Science. November 10, 2006; 314 (5801): 941-52.

Structure, expression, and transcriptional regulation of the Strongylocentrotus franciscanus spec gene family encoding intracellular calcium-binding proteins., Villinski JT, Kiyama T, Dayal S, Zhang N, Liang S, Klein WH., Dev Genes Evol. August 1, 2005; 215 (8): 410-22.

Strongylocentrotus purpuratus transcription factor GATA-E binds to and represses transcription at an Otx-Goosecoid cis-regulatory element within the aboral ectoderm-specific spec2a enhancer., Kiyama T, Zhang N, Dayal S, Yun Lee P, Liang S, Villinski JT, Klein WH., Dev Biol. April 15, 2005; 280 (2): 436-47.

Creation of cis-regulatory elements during sea urchin evolution by co-option and optimization of a repetitive sequence adjacent to the spec2a gene., Dayal S, Kiyama T, Villinski JT, Zhang N, Liang S, Klein WH., Dev Biol. September 15, 2004; 273 (2): 436-53.

Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages., Wikramanayake AH, Peterson R, Chen J, Huang L, Bince JM, McClay DR, Klein WH., Genesis. July 1, 2004; 39 (3): 194-205.

Ectoderm gene activation in sea urchin embryos mediated by the CCAAT-binding factor., Li X, Bhattacharya C, Dayal S, Maity S, Klein WH., Differentiation. May 1, 2002; 70 (2-3): 109-19.

Molecular patterning along the sea urchin animal-vegetal axis., Brandhorst BP, Klein WH., Int Rev Cytol. January 1, 2002; 213 183-232.

Sea urchin goosecoid function links fate specification along the animal-vegetal and oral-aboral embryonic axes., Angerer LM, Oleksyn DW, Levine AM, Li X, Klein WH, Angerer RC., Development. November 1, 2001; 128 (22): 4393-404.

Correct Expression of spec2a in the sea urchin embryo requires both Otx and other cis-regulatory elements., Yuh CH, Li X, Davidson EH, Klein WH., Dev Biol. April 15, 2001; 232 (2): 424-38.

Involvement of Tcf/Lef in establishing cell types along the animal-vegetal axis of sea urchins., Huang L, Li X, El-Hodiri HM, Dayal S, Wikramanayake AH, Klein WH., Dev Genes Evol. February 1, 2000; 210 (2): 73-81.

Requirement of SpOtx in cell fate decisions in the sea urchin embryo and possible role as a mediator of beta-catenin signaling., Li X, Wikramanayake AH, Klein WH., Dev Biol. August 15, 1999; 212 (2): 425-39.

Function and evolution of Otx proteins., Klein WH, Li X., Biochem Biophys Res Commun. May 10, 1999; 258 (2): 229-33.

beta-Catenin is essential for patterning the maternally specified animal-vegetal axis in the sea urchin embryo., Wikramanayake AH, Huang L, Klein WH., Proc Natl Acad Sci U S A. August 4, 1998; 95 (16): 9343-8.

Two Otx proteins generated from multiple transcripts of a single gene in Strongylocentrotus purpuratus., Li X, Chuang CK, Mao CA, Angerer LM, Klein WH., Dev Biol. July 15, 1997; 187 (2): 253-66.

Multiple signaling events specify ectoderm and pattern the oral-aboral axis in the sea urchin embryo., Wikramanayake AH, Klein WH., Development. January 1, 1997; 124 (1): 13-20.

Very early and transient vegetal-plate expression of SpKrox1, a Krüppel/Krox gene from Stronglyocentrotus purpuratus., Wang W, Wikramanayake AH, Gonzalez-Rimbau M, Vlahou A, Flytzanis CN, Klein WH., Mech Dev. December 1, 1996; 60 (2): 185-95.

Altering cell fates in sea urchin embryos by overexpressing SpOtx, an orthodenticle-related protein., Mao CA, Wikramanayake AH, Gan L, Chuang CK, Summers RG, Klein WH., Development. May 1, 1996; 122 (5): 1489-98.

A G/C-rich DNA-regulatory element controls positive expression of the sea urchin Lytechinus pictus aboral ectoderm-specific LpS1 gene., Wang W, Klein WH., DNA Cell Biol. February 1, 1996; 15 (2): 133-45.

Transient appearance of Strongylocentrotus purpuratus Otx in micromere nuclei: cytoplasmic retention of SpOtx possibly mediated through an alpha-actinin interaction., Chuang CK, Wikramanayake AH, Mao CA, Li X, Klein WH., Dev Genet. January 1, 1996; 19 (3): 231-7.

Autonomous and non-autonomous differentiation of ectoderm in different sea urchin species., Wikramanayake AH, Brandhorst BP, Klein WH., Development. May 1, 1995; 121 (5): 1497-505.

An orthodenticle-related protein from Strongylocentrotus purpuratus., Gan L, Mao CA, Wikramanayake A, Angerer LM, Angerer RC, Klein WH., Dev Biol. February 1, 1995; 167 (2): 517-28.

Multiple Otx binding sites required for expression of the Strongylocentrotus purpuratus Spec2a gene., Mao CA, Gan L, Klein WH., Dev Biol. September 1, 1994; 165 (1): 229-42.

A positive cis-regulatory element with a bicoid target site lies within the sea urchin Spec2a enhancer., Gan L, Klein WH., Dev Biol. May 1, 1993; 157 (1): 119-32.

Developmental potential of muscle cell progenitors and the myogenic factor SUM-1 in the sea urchin embryo., Venuti JM, Gan L, Kozlowski MT, Klein WH., Mech Dev. April 1, 1993; 41 (1): 3-14.

Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers., Sirito M, Walker S, Lin Q, Kozlowski MT, Klein WH, Sawadogo M., Gene Expr. January 1, 1992; 2 (3): 231-40.

Sea urchin USF: a helix-loop-helix protein active in embryonic ectoderm cells., Kozlowski MT, Gan L, Venuti JM, Sawadogo M, Klein WH., Dev Biol. December 1, 1991; 148 (2): 625-30.

A G-string positive cis-regulatory element in the LpS1 promoter binds two distinct nuclear factors distributed non-uniformly in Lytechinus pictus embryos., Xiang M, Lu SY, Musso M, Karsenty G, Klein WH., Development. December 1, 1991; 113 (4): 1345-55.

A myogenic factor from sea urchin embryos capable of programming muscle differentiation in mammalian cells., Venuti JM, Goldberg L, Chakraborty T, Olson EN, Klein WH., Proc Natl Acad Sci U S A. July 15, 1991; 88 (14): 6219-23.

Structure and promoter activity of the LpS1 genes of Lytechinus pictus. Duplicated exons account for LpS1 proteins with eight calcium binding domains., Xiang MQ, Ge T, Tomlinson CR, Klein WH., J Biol Chem. June 5, 1991; 266 (16): 10524-33.

Regulatory elements from the related spec genes of Strongylocentrotus purpuratus yield different spatial patterns with a lacZ reporter gene., Gan L, Wessel GM, Klein WH., Dev Biol. December 1, 1990; 142 (2): 346-59.

Ectoderm nuclei from sea urchin embryos contain a Spec-DNA binding protein similar to the vertebrate transcription factor USF., Tomlinson CR, Kozlowski MT, Klein WH., Development. September 1, 1990; 110 (1): 259-72.

Myosin heavy chain accumulates in dissimilar cell types of the macromere lineage in the sea urchin embryo., Wessel GM, Zhang W, Klein WH., Dev Biol. August 1, 1990; 140 (2): 447-54.

Repetitive DNA sequences linked to the sea urchin spec genes contain transcriptional enhancer-like elements., Gan L, Zhang W, Klein WH., Dev Biol. May 1, 1990; 139 (1): 186-96.

Temporal and spatial transcriptional regulation of the aboral ectoderm-specific Spec genes during sea urchin embryogenesis., Tomlinson CR, Klein WH., Mol Reprod Dev. April 1, 1990; 25 (4): 328-38.

Localization of the sea urchin Spec3 protein to cilia and Golgi complexes of embryonic ectoderm cells., Eldon ED, Montpetit IC, Nguyen T, Decker G, Valdizan MC, Klein WH, Brandhorst BP., Genes Dev. January 1, 1990; 4 (1): 111-22.

Gastrulation in the sea urchin is accompanied by the accumulation of an endoderm-specific mRNA., Wessel GM, Goldberg L, Lennarz WJ, Klein WH., Dev Biol. December 1, 1989; 136 (2): 526-36.

Transcription of the Spec 1-like gene of Lytechinus is selectively inhibited in response to disruption of the extracellular matrix., Wessel GM, Zhang W, Tomlinson CR, Lennarz WJ, Klein WH., Development. June 1, 1989; 106 (2): 355-65.

Tandem duplication and divergence of a sea urchin protein belonging to the troponin C superfamily., Xiang MQ, Bédard PA, Wessel G, Filion M, Brandhorst BP, Klein WH., J Biol Chem. November 15, 1988; 263 (32): 17173-80.

Spec2 genes of Strongylocentrotus purpuratus. Structure and differential expression in embryonic aboral ectoderm cells., Hardin PE, Angerer LM, Hardin SH, Angerer RC, Klein WH., J Mol Biol. August 5, 1988; 202 (3): 417-31.

Spec3: embryonic expression of a sea urchin gene whose product is involved in ectodermal ciliogenesis., Eldon ED, Angerer LM, Angerer RC, Klein WH., Genes Dev. December 1, 1987; 1 (10): 1280-92.

Use of consensus oligonucleotides for detecting and isolating nucleic acids encoding calcium binding domains of the troponin C superfamily., Hardin SH, Keast MJ, Hardin PE, Klein WH., Biochemistry. June 16, 1987; 26 (12): 3518-23.

Unusual sequence conservation in the 5'' and 3'' untranslated regions of the sea urchin spec mRNAs., Hardin PE, Klein WH., J Mol Evol. January 1, 1987; 25 (2): 126-33.

Calmodulin gene expression during sea urchin development: persistence of a prevalent maternal protein., Floyd EE, Gong ZY, Brandhorst BP, Klein WH., Dev Biol. February 1, 1986; 113 (2): 501-11.

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