Dr. Maria C Roccheri
Two lines of research have been followed so far: 1) Response of developing sea urchin embryos (P. lividus) to different type of stress; 2) Apoptosis in cells of the human cumulus oophorus. In particular the research was focused on: -Studies on ribosomal RNA processing". -Studies on heat shock proteins induction in stress conditions (heat shock, metal such as zinc and cadmium, EGTA, deciliation), during embryo development. -Studies on apoptosis and autophagy in embryo development. -Studies on cell defense and death in Cd-treated embryos. -Studies on the effects exerted by cytotoxic doses of Manganese on embryo development, focused in particular on MAPK activation and expression of msp130 and sm30. -Studies on mitochondrial activity in the different developmental stages of control and stressed embryos with particular interest on the distribution of hsp60 mRNA and protein. -Studies on programmed cell death in human oocytes after PMA with particular interest on DNA status. -Studies on the onset of apoptosis in cells of the human cumulus oophorus in patients subjected to induction of multiple follicular growth by r-FSH or u-FSH. -Studies on DNA fragmention in spermatozoa of infertile patients.
Università degli Studi di Palermo