Bioessays 1989 Jul 01;111:27-34. doi: 10.1002/bies.950110108.

Do ribosomes regulate mitochondrial RNA synthesis?

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The levels of different classes of mitochondrially encoded transcripts are developmentally regulated in sea urchin embryos, as a result of selection between mutually exclusive synthetic pathways. I propose a simple model to explain these observations, based on a dual role for mitochondrial ribosomes and translation factors in RNA synthesis as well as in translation. This effect may be exerted either at the transcriptional or post-transcriptional level (or both), and is potentially generalizable to mammalian mtDNA and to other systems.

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Genes referenced: LOC100887844